Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lena Thyrell"'
Autor:
Katja Pokrovskaja Tamm, Lena Thyrell, Velmurugesan Arulampalam, Marianne Farnebo, Linn Hjortsberg, Dan Grandér
Publikováno v:
Experimental Cell Research. 313:4015-4024
In multiple myeloma, which commonly depends on interleukin 6, IL-6, survival signaling induced by this cytokine is largely mediated by activation of STAT3. Interferon alpha (IFNalpha) treatment of cell lines derived from multiple myeloma or of myelom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ff2382f802e425107abdb453ced6b3
https://doi.org/10.1016/j.yexcr.2007.08.007
https://doi.org/10.1016/j.yexcr.2007.08.007
Autor:
Katja Pokrovskaja, Theocharis Panaretakis, Ingo B. Leibiger, Markus Dagnell, Linn Hjortsberg, Lena Thyrell, Sabine Uhles, Boris Zhivotovsky, Velmurugesan Arulampalam, Dan Grandér
Publikováno v:
Journal of Biological Chemistry. 279:24152-24162
Interferon (IFN) alpha induces a caspase-dependent apoptosis that is associated with activation of the proapoptotic Bak and Bax, loss of mitochondrial membrane potential, and release of cytochrome c. In addition to the onset of the classical Jak-STAT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1444a0e64cff33919a9c1b49796a90d
https://doi.org/10.1074/jbc.m312219200
https://doi.org/10.1074/jbc.m312219200
Autor:
Sampsa Matikainen, Stefan Einhorn, Lena Thyrell, Sven Erickson, Olle Sangfelt, Ilkka Julkunen, Dan Grandér
Publikováno v:
European Journal of Biochemistry. 269:29-37
It has previously been shown that IFN-alpha is a potent inhibitor of IL-2 induced proliferation in primary T-lymphocytes, by selectively abrogating the downstream effects of IL-2 on the core cell cycle machinery regulating the G1/S transition. Theore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa44fce9f0e9001ae2293386643bcc7b
https://doi.org/10.1046/j.0014-2956.2002.02626.x
https://doi.org/10.1046/j.0014-2956.2002.02626.x
Autor:
Salah Mahmoudi, Pedram Kharaziha, Dan Grandér, Anders Ullén, Marianne Farnebo, Theoharis Panaretakis, Lena Lennartsson, Lena Thyrell, Sten Nilsson
Publikováno v:
International Journal of Oncology. 37
The multiple tyrosine kinase inhibitor sorafenib has recently demonstrated clinical effects in patients with androgen-independent prostate cancer. These observations provided the rational for investigating the anti-tumoral properties of this compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b900b608e8d5745ffb14c026a2111d
https://doi.org/10.3892/ijo_00000648
https://doi.org/10.3892/ijo_00000648
Autor:
Dominic Chan, Linn Hjortsberg, Velmurugesan Arulampalam, Martin Corcoran, Dan Grandér, Magnus Nordenskjöld, Lena Thyrell, Katja Pokrovskaja, Charlotta Lindvall
Publikováno v:
Karolinska Institutet
IFNalpha activates JAK-STAT signaling, followed by up-regulation of a cohort of genes. Also the PI3K pathway is activated by IFNalpha, but the significance of this activation for IFN-induced gene expression and biological functions remains unclear. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceb8372087251a11cb0c7328ceb28737
https://pubmed.ncbi.nlm.nih.gov/17141757
https://pubmed.ncbi.nlm.nih.gov/17141757
Autor:
Sven, Erickson, Sampsa, Matikainen, Lena, Thyrell, Olle, Sangfelt, Ilkka, Julkunen, Stefan, Einhorn, Dan, Grandér
Publikováno v:
European journal of biochemistry. 269(1)
It has previously been shown that IFN-alpha is a potent inhibitor of IL-2 induced proliferation in primary T-lymphocytes, by selectively abrogating the downstream effects of IL-2 on the core cell cycle machinery regulating the G1/S transition. Theore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db09a6bfc821cd742e5003632c7d1e1d
https://pubmed.ncbi.nlm.nih.gov/11784295
https://pubmed.ncbi.nlm.nih.gov/11784295
Autor:
Olle Sangfelt, Stefan Einhorn, Juan Castro, Lena Thyrell, Dan Grandér, Sven Erickson, Boris Zhivotovsky, Katja Pokrovskaja
Publikováno v:
Oncogene. 21(8)
Interferon alpha (IFNalpha) has been used in the treatment of several types of cancer for almost 30 years, yet the mechanism(s) responsible for its anti-tumoral action remains unknown. A variety of cellular responses, including inhibition of cell gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf8c06248d2e9175f688c6a58d21a1c
https://pubmed.ncbi.nlm.nih.gov/11850845
https://pubmed.ncbi.nlm.nih.gov/11850845
Autor:
Lena Thyrell, Olle Sangfelt, Boris Zhivotovsky, Katja Pokrovskaja, Yisong Wang, Stefan Einhorn, Dan Grandr
Publikováno v:
Journal of Interferon & Cytokine Research; Feb2005, Vol. 25 Issue 2, p63-72, 10p