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VEGF synthesis is induced by prostacyclin and TGF-β in distal lung fibroblasts from COPD patients and control subjects: Implications for pulmonary vascular remodelling

Autor: Mariam Bagher, Leif Bjermer, Gunilla Westergren-Thorsson, Claes-Göran Löfdahl, Lena Thiman, Anna-Karin Larsson-Callerfelt, Annika Andersson-Sjöland, Oskar Hallgren

Publikováno v: Respirology. 23:68-75

Background and objective Involvement of pulmonary vascular remodelling is a characteristic sign in COPD. Vascular mediators such as vascular endothelial growth factor (VEGF) and prostacyclin may regulate fibroblast activity. The objective was to stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1c257fa9140f7993452d38d6c90dcf6
https://doi.org/10.1111/resp.13142

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VEGF synthesis and VEGF receptor 2 expression in patients with bronchiolitis obliterans syndrome after lung transplantation

Autor: Lena Thiman, Hillevi Larsson, Gunilla Westergren-Thorsson, Leif Bjermer, Anna-Karin Larsson-Callerfelt, Oskar Hallgren, Catharina Müller, Leif Eriksson, Annika Andersson-Sjöland

Publikováno v: Respiratory medicine. 166

Chronic lung allograft dysfunction including Bronchiolitis obliterans syndrome (BOS) is common after lung transplantation. Histologically, BOS is recognized as fibrotic lesions with accumulated extracellular matrix (ECM) in small airways. Lung fibrob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1b4ee471d32bde1cf1d03e0f6aa436
https://pubmed.ncbi.nlm.nih.gov/32250877

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VEGF induces ECM synthesis and fibroblast activity in human lung fibroblasts

Autor: Mariam Bagher, Claes-Göran Löfdahl, Anna-Karin Larsson-Callerfelt, Gunilla Westergren-Thorsson, Oskar Hallgren, Lena Thiman, Leif Bjermer, Annika Andersson Sjöland

Publikováno v: Airway Pharmacology and Treatment.

Pulmonary vascular remodelling is a characteristic sign in different lung disorders. Vascular endothelial growth factor (VEGF) is a key mediator in vascular remodelling. The objective was to study the role of VEGF on fibroblast activity, such as extr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::546933efb693a541bdc00a7a19a0185f
https://doi.org/10.1183/1393003.congress-2017.pa1045

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VEGF synthesis is induced by prostacyclin and TGF-β in distal lung fibroblasts from COPD patients and control subjects: Implications for pulmonary vascular remodelling

Autor: Gunilla, Westergren-Thorsson, Mariam, Bagher, Annika, Andersson-Sjöland, Lena, Thiman, Claes-Göran, Löfdahl, Oskar, Hallgren, Leif, Bjermer, Anna-Karin, Larsson-Callerfelt

Publikováno v: Respirology (Carlton, Vic.). 23(1)

Involvement of pulmonary vascular remodelling is a characteristic sign in COPD. Vascular mediators such as vascular endothelial growth factor (VEGF) and prostacyclin may regulate fibroblast activity. The objective was to study the synthesis of VEGF a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8672bfa6b2bba6e0e49565c09a6de005
https://pubmed.ncbi.nlm.nih.gov/28834088

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Evaluation of nanoparticles in human lung fibroblasts and PCLS

Autor: Hanna L. Karlsson, Lena Thiman, Gunilla Westergren-Thorsson, Anna-Karin Larsson-Callerfelt, Vendela Rissler

Publikováno v: 5.1 Airway Pharmacology and Treatment.

Background: Nanoparticles (1-100 nm) possess unusual properties related to size, shape, and chemical composition and can be used for specific targeting of cells and potential drug delivery. However, the use of nanoparticles for drug delivery into the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52e995727ebc85ab88849f11db413b65
https://doi.org/10.1183/13993003.congress-2016.oa4543

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Prostacyclin and VEGF in the rejection process after lung transplantation – A possible biomarker

Autor: Lennart Hansson, Leif Bjermer, Annika Andersson Sjöland, Oskar Hallgren, Lena Thiman, Anna-Karin Larsson Callerfelt, Leif Eriksson, Gunilla Westergren-Thorsson, Ingrid Skog

Publikováno v: 3.3 Mechanisms of Lung Injury and Repair.

Many lung-transplanted (LTx) patients develop obliterative bronchiolitis (OB) with deposition of extracellular matrix, accompanied by fibrocyte infiltration and increased lumen of vessels. In this study we hypothesize that fibrocytes, VEGF and prosta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc6ec8d84ae29daf31ac66508c264481
https://doi.org/10.1183/13993003.congress-2016.pa4040

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5‐HT 2B receptor antagonists attenuate myofibroblast differentiation and subsequent fibrotic responses in vitro and in vivo

Autor: Anna Löfdahl, Catharina Müller, C. Martina Holst, Anna-Karin Larsson-Callerfelt, Gunilla Westergren-Thorsson, Gunilla Ekstrom, Kristina Rydell-Törmänen, Christina Wenglén, Lena Thiman

Publikováno v: Physiological Reports

Pulmonary fibrosis is characterized by excessive accumulation of connective tissue, along with activated extracellular matrix (ECM)‐producing cells, myofibroblasts. The pathological mechanisms are not well known, however serotonin (5‐HT) and 5‐

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c040866e1084dac340467b8a298a338
http://europepmc.org/articles/PMC4985542

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Importance of polyamines in cell cycle kinetics as studied in a transgenic system

Autor: Lo Persson, Sima Nasizadeh, Kersti Alm, Lena Thiman, Stina Oredsson, Louise Myhre

Publikováno v: Experimental Cell Research. 308:254-264

Polyamines are organic cations, which are considered essential for normal cell cycle progression. This view is based on results from numerous studies using a variety of enzyme inhibitors or polyamine analogues interfering with either the metabolism o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562bad5fbb00d7c5d4d16370a82cb91f
https://doi.org/10.1016/j.yexcr.2005.04.027

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