Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Lena Stich"'
Autor:
Katrin Peckert-Maier, Andreas B. Wild, Laura Sprißler, Maximilian Fuchs, Philipp Beck, Jean-Philippe Auger, Pia Sinner, Astrid Strack, Petra Mühl-Zürbes, Ntilek Ramadan, Meik Kunz, Gerhard Krönke, Lena Stich, Alexander Steinkasserer, Dmytro Royzman
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Alterations in macrophage (Mφ) polarization, function, and metabolic signature can foster development of chronic diseases, such as autoimmunity or fibrotic tissue remodeling. Thus, identification of novel therapeutic agents that modulate human Mφ b
Externí odkaz:
https://doaj.org/article/ebaecb1fe44b410fa7de1e8626ca690e
Autor:
Katrin Peckert-Maier, Pia Langguth, Astrid Strack, Lena Stich, Petra Mühl-Zürbes, Christine Kuhnt, Christina Drassner, Elisabeth Zinser, Marius Wrage, Jochen Mattner, Alexander Steinkasserer, Dmytro Royzman, Andreas B. Wild
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Excessive macrophage (Mφ) activation results in chronic inflammatory responses or autoimmune diseases. Therefore, identification of novel immune checkpoints on Mφ, which contribute to resolution of inflammation, is crucial for the development of ne
Externí odkaz:
https://doaj.org/article/1a0d798c26b848068ab4b38b25d588a3
Autor:
Dmytro Royzman, Katrin Peckert-Maier, Lena Stich, Christina König, Andreas B. Wild, Miyuki Tauchi, Christian Ostalecki, Franklin Kiesewetter, Stefan Seyferth, Geoffrey Lee, Sabine A. Eming, Maximilian Fuchs, Meik Kunz, Ewa K. Stürmer, Eva M. J. Peters, Carola Berking, Elisabeth Zinser, Alexander Steinkasserer
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
To facilitate the recovery process of chronic and hard-to-heal wounds novel pro-resolving treatment options are urgently needed. We investigated the pro-regenerative properties of soluble CD83 (sCD83) on cutaneous wound healing, where sCD83 accelerat
Externí odkaz:
https://doaj.org/article/1c5189c1d0044a92a854191e8b60e1a3
Autor:
Dmytro Royzman, Darja Andreev, Lena Stich, Katrin Peckert-Maier, Andreas B. Wild, Elisabeth Zinser, Petra Mühl-Zürbes, Evan Jones, Susanne Adam, Silke Frey, Maximilian Fuchs, Meik Kunz, Tobias Bäuerle, Lisa Nagel, Georg Schett, Aline Bozec, Alexander Steinkasserer
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Here we show that soluble CD83 induces the resolution of inflammation in an antigen-induced arthritis (AIA) model. Joint swelling and the arthritis-related expression levels of IL-1β, IL-6, RANKL, MMP9, and OC-Stamp were strongly reduced, while Foxp
Externí odkaz:
https://doaj.org/article/576ad5b73c124cb0990703d4d392cc97
Autor:
Atefeh Sadeghi Shermeh, Dmytro Royzman, Christine Kuhnt, Christina Draßner, Lena Stich, Alexander Steinkasserer, Ilka Knippertz, Andreas B. Wild
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 7801 (2023)
The aryl hydrocarbon receptor (AhR) is a decisive regulatory ligand-dependent transcription factor. It binds highly diverse ligands, which can be categorized as either endogenous or exogenous. Ligand binding activates AhR, which can adjust inflammato
Externí odkaz:
https://doaj.org/article/e1084f711d9943b8b8148b7b775394c3
Autor:
Jung-Hyun Lee, Christian Ostalecki, Timo Oberstein, Stefan Schierer, Elisabeth Zinser, Martin Eberhardt, Katja Blume, Bianca Plosnita, Lena Stich, Heiko Bruns, Roland Coras, Julio Vera-Gonzales, Manuel Maler, Andreas S. Baur
Publikováno v:
EBioMedicine, Vol 77, Iss , Pp 103903- (2022)
Summary: Background: Plasma extracellular vesicles (pEV) can harbor a diverse array of factors including active proteases and the amyloid-precursor-protein (APP) cleavage product Aβ, involved in plaque formation in Alzheimer`s diseases (AD). A poten
Externí odkaz:
https://doaj.org/article/0ef1dff6be234781983852ab5596a110
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3949 (2022)
European black elderberry (Sambucus nigra L.) is a popular way to treat common colds or influenza infections. Mechanistically, this might be due to a direct antiviral effect or a stimulatory effect on the immune system of the host. Here, we evaluated
Externí odkaz:
https://doaj.org/article/419e2cb42cf24446b35ad7315a70a5a7
Autor:
Elisabeth Zinser, Ronald Naumann, Andreas B. Wild, Julia Michalski, Andrea Deinzer, Lena Stich, Christine Kuhnt, Alexander Steinkasserer, Ilka Knippertz
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The CD83 is a type I membrane protein and part of the immunoglobulin superfamily of receptors. CD83 is involved in the regulation of antigen presentation and dendritic cell dependent allogeneic T cell proliferation. A soluble form of CD83 inhibits de
Externí odkaz:
https://doaj.org/article/ee74b555661043379c0e8558e43ca12c
Autor:
Dmytro Royzman, Darja Andreev, Lena Stich, Manfred Rauh, Tobias Bäuerle, Stephan Ellmann, Louis Boon, Markus Kindermann, Katrin Peckert, Aline Bozec, Georg Schett, Alexander Steinkasserer, Elisabeth Zinser
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Interference with autoimmune-mediated cytokine production is a key yet poorly developed approach to treat autoimmune and inflammatory diseases such as rheumatoid arthritis. Herein, we show that soluble CD83 (sCD83) enhances the resolution of autoimmu
Externí odkaz:
https://doaj.org/article/aad69cc2db014653827f30160fbd18d1
Autor:
Alfrun Schönberg, Alexander Steinkasserer, Elisabeth Zinser, Dmytro Royzman, Katrin Peckert-Maier, Gabriele Braun, Felix Bock, Claus Cursiefen, Karina Hadrian, Philipp Tripal, Lena Stich, Andreas B. Wild
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsREFERENCES. 22(2)
Immune responses reflect a complex interplay of cellular and extracellular components which define the microenvironment of a tissue. Therefore, factors that locally influence the microenvironment and re-establish tolerance might be beneficial to miti