Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lena Shirinian"'
Autor:
Daniel A Cannon, Lu Shan, Qun Du, Lena Shirinian, Keith W Rickert, Kim L Rosenthal, Martin Korade, Lilian E van Vlerken-Ysla, Andrew Buchanan, Tristan J Vaughan, Melissa M Damschroder, Bojana Popovic
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 5, p e1006980 (2019)
Antibodies are an important class of therapeutics that have significant clinical impact for the treatment of severe diseases. Computational tools to support antibody drug discovery have been developing at an increasing rate over the last decade and t
Externí odkaz:
https://doaj.org/article/5c50a244ed204541b31f7ba74cb15714
Autor:
Daniel R. Higazi, Michael A. Bowen, Nicholas J. Bond, Rebecca Dunmore, Lynne Murray, William Dall'acqua, Yanli Wu, Jie Zhu, Toyin Kasali, M. Jack Borrok, Lena Shirinian, Arnita Barnes, Catherine Huntington, Sandrina Phipps, John Hood, Emilie Solier, Ping Tsui, Keith W Rickert, Alan M. Carruthers
Publikováno v:
mAbs. 9:104-113
Excessive transforming growth factor (TGF)-β is associated with pro-fibrotic responses in lung disease, yet it also plays essential roles in tissue homeostasis and autoimmunity. Therefore, selective inhibition of excessive and aberrant integrin-medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d570ca136c988614413eb835598fa70
https://doi.org/10.1080/19420862.2016.1255390
https://doi.org/10.1080/19420862.2016.1255390
Autor:
Kim Rosenthal, Andrew Buchanan, Lilian E. van Vlerken-Ysla, Tristan J Vaughan, Bojana Popovic, Qun Du, Lena Shirinian, Martin Korade, Daniel Cannon, Keith W. Rickert, Lu Shan, Melissa Damschroder
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 5, p e1006980 (2019)
PLoS Computational Biology
PLoS Computational Biology
Antibodies are an important class of therapeutics that have significant clinical impact for the treatment of severe diseases. Computational tools to support antibody drug discovery have been developing at an increasing rate over the last decade and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8d1b730997e8226d999c306fdec9f2
https://doi.org/10.1371/journal.pcbi.1006980
https://doi.org/10.1371/journal.pcbi.1006980
Autor:
Peter A. Kiener, Ryan Fleming, Herren Wu, Lena Shirinian, Robert M. Woods, Xiao-Tao Yao, Changshou Gao, Nazzareno Dimasi
Publikováno v:
Journal of Molecular Biology. 393:672-692
Monoclonal antibodies are traditionally used to block the function of a specific target in a given disease. However, some diseases are the consequence of multiple components or pathways and not the result of a single mediator; thus, blocking at a sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2820eafe2c208b25cde779edc9bb29f8
https://doi.org/10.1016/j.jmb.2009.08.032
https://doi.org/10.1016/j.jmb.2009.08.032
Autor:
Ronald Herbst, Tomas Mustelin, Marcus R. Clark, Lorraine Clarke, Deepak B. Khatry, Liat Izhak, Jill Henault, Kerry A. Casey, Michelle Petri, Rachel Ettinger, Lena Shirinian, Roland Kolbeck, Vladimir M. Liarski, Jodi L. Karnell, Linda Xu, Jeffrey M. Riggs, Miguel A. Sanjuan, Michael A Smith, Jianqing Li
Publikováno v:
Nature immunology. 17(2)
Canonically, immunoglobulin E (IgE) mediates allergic immune responses by triggering mast cells and basophils to release histamine and type 2 helper cytokines. Here we found that in human systemic lupus erythematosus (SLE), IgE antibodies specific fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04752d0f977d48c766393162294c0bc0
https://pubmed.ncbi.nlm.nih.gov/26794873
https://pubmed.ncbi.nlm.nih.gov/26794873
Autor:
Andriy Anishkin, Vyacheslav Gendel, Lena Shirinian, H. Robert Guy, Chien-Sung Chiang, Sergei Sukharev, Neda A. Sharifi
Publikováno v:
The Journal of General Physiology
COOH-terminal (S3) domains are conserved within the MscL family of bacterial mechanosensitive channels, but their function remains unclear. The X-ray structure of MscL from Mycobacterium tuberculosis (TbMscL) revealed cytoplasmic domains forming a pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f253537e7cacfe50d2ede14c9e647a47
https://doi.org/10.1085/jgp.20028768
https://doi.org/10.1085/jgp.20028768
Autor:
Jeffrey M. Riggs, Kerry A. Casey, Ronald Herbst, Linda Xu, Michael A Smith, Jill Henault, Jodi L. Karnell, Roland Kolbeck, Rachel Ettinger, Lena Shirinian, Miguel A. Sanjuan, M. Petri, Marcus R. Clark, Deepak B. Khatry, Tomas Mustelin, Lorraine Clarke, Vladimir M. Liarski
Publikováno v:
Annals of the Rheumatic Diseases. 75:946.2-947
Background The discovery of Immunoglobulin E (IgE) nearly 40 years ago was a breakthrough in the field of allergy research. IgE directed against parasitic worms and allergens binds mast cells and basophils, triggering an inflammatory response that is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3700c0a0b6633eabea717473f43b6559
https://doi.org/10.1136/annrheumdis-2016-eular.3791
https://doi.org/10.1136/annrheumdis-2016-eular.3791
Publikováno v:
Biochemistry. 44(37)
Tyrosines and tryptophans that anchor both ends of the helices to membrane interfaces in many transmembrane proteins are not common in MscL and homologous mechanosensitive channels. This characteristic absence of two aromatic "belts" may be critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e2297606d596019564c80a92587061
https://pubmed.ncbi.nlm.nih.gov/16156671
https://pubmed.ncbi.nlm.nih.gov/16156671