Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Lena Schumacher"'
Autor:
Nikolai Tschernoster, Florian Erger, Stefan Kohl, Björn Reusch, Andrea Wenzel, Stephen Walsh, Holger Thiele, Christian Becker, Marek Franitza, Malte P. Bartram, Martin Kömhoff, Lena Schumacher, Christian Kukat, Tatiana Borodina, Claudia Quedenau, Peter Nürnberg, Markus M Rinschen, Jan H. Driller, Bjørn P. Pedersen, Karl P. Schlingmann, Bruno Hüttel, Detlef Bockenhauer, Bodo Beck, Janine Altmüller
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-17 (2023)
Abstract Background Long-read sequencing is increasingly used to uncover structural variants in the human genome, both functionally neutral and deleterious. Structural variants occur more frequently in regions with a high homology or repetitive segme
Externí odkaz:
https://doaj.org/article/562f2d8f33f64894b552c46d64c66672
Autor:
Manasi Gaikwad, Florian Richter, Rabea Götz, Aline Dörrbaum, Lena Schumacher, Jason Tonillo, Christian Frech, Roland Kellner, Carsten Hopf
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1418 (2023)
Studies of structural changes in mAbs under forced stress and storage conditions are essential for the recognition of degradation hotspots, which can be further remodeled to improve the stability of the respective protein. Herein, we used diethyl pyr
Externí odkaz:
https://doaj.org/article/0daf1a485f8e4053b1fd4f3c7305886e
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52074 (2012)
Sequential tool use is defined as using a tool to obtain another non-food object which subsequently itself will serve as a tool to act upon a further (sub)goal. Previous studies have shown that birds and great apes succeed in such tasks. However, the
Externí odkaz:
https://doaj.org/article/9e4172cda23a4ce9b6d1764c43afa417
Autor:
Anna Juliane Vesting, Alexander Jais, Paul Klemm, Lukas Steuernagel, Peter Wienand, Morten Fog-Tonnesen, Henning Hvid, Anna–Lena Schumacher, Christian Kukat, Hendrik Nolte, Theodoros Georgomanolis, Janine Altmüller, Manolis Pasparakis, Andreas Schmidt, Marcus Krüger, Marc Schmidt Supprian, Ari Waisman, Beate Katharina Straub, Nathanael Raschzok, Michel Bernier, Andreas L. Birkenfeld, Nadine Hövelmeyer, Jens C. Brüning, F. Thomas Wunderlich
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101626- (2022)
Objective: Nonalcoholic fatty liver disease (NAFLD) ranges from steatosis to nonalcoholic steatohepatitis (NASH), which often progresses to hepatocellular carcinoma (HCC) through a largely undefined mechanism. NASH and HCC depend on inflammatory sign
Externí odkaz:
https://doaj.org/article/2bae8d5e2cd240e7ae3c80f88b871897
Autor:
Andromachi Pouikli, Monika Maleszewska, Swati Parekh, Ming Yang, Chrysa Nikopoulou, Juan Jose Bonfiglio, Constantine Mylonas, Tonantzi Sandoval, Anna‐Lena Schumacher, Yvonne Hinze, Ivan Matic, Christian Frezza, Peter Tessarz
Publikováno v:
EMBO J
Bone-derived mesenchymal stem cells (MSCs) reside in a hypoxic niche that maintains their differentiation potential. While hypoxia (low oxygen concentration) was reported to critically support stem cell function and osteogenesis, the molecular events
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d0cd20a48f5b803c3db79a7ed4e152
https://doi.org/10.15252/embj.2022111239
https://doi.org/10.15252/embj.2022111239
Autor:
Nikolai Tschernoster, Florian Erger, Patrick R. Walsh, Bairbre McNicholas, Margareta Fistrek, Sandra Habbig, Anna-Lena Schumacher, Kat Folz-Donahue, Christian Kukat, Mohammad R. Toliat, Christian Becker, Holger Thiele, David Kavanagh, Peter Nürnberg, Bodo B. Beck, Janine Altmüller
Complement factor H (CFH) and its related proteins have an essential role in regulating the alternative pathway of the complement system. Mutations and structural variants (SVs) of the CFH gene cluster, consisting of CFH and its five related genes (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732e0bcb18f71ec36b290d0afad9c9d8
http://edoc.mdc-berlin.de/21545/1/21545oa.pdf
http://edoc.mdc-berlin.de/21545/1/21545oa.pdf
Autor:
Pablo Rivera-Mejías, Álvaro Jesús Narbona-Pérez, Lidwina Hasberg, Lara Kroczek, Amir Bahat, Steffen Lawo, Kat Folz-Donahue, Anna-Lena Schumacher, Sofia Ahola, Fiona Carola Mayer, Patrick Giavalisco, Hendrik Nolte, Sergio Lavandero, Thomas Langer
Publikováno v:
Cell Reports. 42:112332
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e293fe8c2971835be999ebe7398e3c1
https://doi.org/10.1016/j.celrep.2023.112332
https://doi.org/10.1016/j.celrep.2023.112332
Autor:
Andromachi Pouikli, Monika Maleszewska, Swati Parekh, Chrysa Nikopoulou, Juan-Jose Bonfiglio, Constantine Mylonas, Tonantzi Sandoval, Anna-Lena Schumacher, Yvonne Hinze, Ivan Matic, Peter Tessarz
Bone marrow mesenchymal stem cells (MSCs) reside in a hypoxic niche that maintains their differentiation potential. Several studies have highlighted the critical role of hypoxia (low oxygen concentration) in the regulation of stem cell function, repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a5590500d1bb39c3c33c88e143daf75
https://doi.org/10.1101/2022.02.26.482117
https://doi.org/10.1101/2022.02.26.482117
Publikováno v:
Cancer letters. 520
The anthracycline derivative doxorubicin (Doxo) induces DNA double-strand breaks (DSBs) by inhibition of DNA topoisomerase type II. Defective mismatch repair (MMR) contributes to Doxo resistance and has been reported for colon and mammary carcinomas.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf128e6f110789474c1b51a12acc1d0
https://pubmed.ncbi.nlm.nih.gov/34389435
https://pubmed.ncbi.nlm.nih.gov/34389435
Autor:
Friedrich B M Reinhard, Anne T. Nies, Gerard Drewes, Melissa S Unger, David Weigt, Maciej J. Zamek-Gliszczynski, Sandra Schulz, Thomas Enzlein, Carsten Hopf, Matthias Schwab, Lena Schumacher
Publikováno v:
Analytical chemistry. 92(17)
OATP2B1, a member of the solute carrier (SLC) transporter family, is an important mechanism of substrate drug uptake in the intestine and liver and therefore a determinant of clinical pharmacokinetics and site of drug-drug interactions. Other SLC tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e648759575120a13b2ba2bb04db73f1
https://pubmed.ncbi.nlm.nih.gov/32867487
https://pubmed.ncbi.nlm.nih.gov/32867487