Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lena S. Yoo"'
Autor:
Khai Phan, Kenneth A. Jacobson, Francesca Deflorian, Lena S. Yoo, Zhan-Guo Gao, Qiang Wei, Dilip K. Tosh
Publikováno v:
Bioconjugate Chemistry. 23:232-247
Adenosine derivatives were modified with alkynyl groups on N(6) substituents for linkage to carriers using Cu(I)-catalyzed click chemistry. Two parallel series, both containing a rigid North-methanocarba (bicyclo[3.1.0]hexane) ring system in place of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453424bfdda38735838f50583d6a6fb2
https://doi.org/10.1021/bc200526c
https://doi.org/10.1021/bc200526c
Autor:
Kenneth A. Jacobson, Bidhan A. Shinkre, Shilpi Mishra, Francesca Deflorian, Khai Phan, Miklós Kecskés, Lena S. Yoo, Zhan-Guo Gao, William C. Trenkle, Angela Szabo, T. Santhosh Kumar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2740-2745
Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine derivatives such as SCH 442416 display high affinity and selectivity as antagonists for the human A(2A) adenosine receptor (AR). We extended ether-linked chain substituents at the p-position of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca482a8c07306117c1283ceaca9ab06
https://doi.org/10.1016/j.bmcl.2010.11.082
https://doi.org/10.1016/j.bmcl.2010.11.082
Autor:
Kenneth A. Jacobson, Lak Shin Jeong, Lena S. Yoo, Zhan Guo Gao, Jin Hee Lee, Hea Ok Kim, Xiyan Hou, Seul Gi Park, Sun Choi, Kyunglim Kim, Varughese Alexander
Publikováno v:
ACS Medicinal Chemistry Letters. 1:516-520
The truncated C2- and C8-substituted 4′-thioadenosine derivatives 4a−d were synthesized from d-mannose, using palladium-catalyzed cross-coupling reactions as key steps. In this study, an A3 adenosine receptor (AR) antagonist, truncated 4′-thioa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0522ac67f4f70c3510497f047fd7a498
https://doi.org/10.1021/ml1001823
https://doi.org/10.1021/ml1001823
Autor:
Moshe Chinn, Dong Wook Kang, Zhan-Guo Gao, Lena S. Yoo, Dilip K. Tosh, Hans Luecke, Kenneth A. Jacobson
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:508-517
We modified a series of (N)-methanocarba nucleoside 5'-uronamides to contain dialkyne groups on an extended adenine C2 substituent, as synthetic intermediates leading to potent and selective A(3) adenosine receptor (AR) agonists. The proximal alkyne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b4382d5d9650eca1a94885a590f41d
https://doi.org/10.1016/j.bmc.2009.12.018
https://doi.org/10.1016/j.bmc.2009.12.018
Autor:
Xiyan, Hou, Hea Ok, Kim, Varughese, Alexander, Kyunglim, Kim, Sun, Choi, Seul-Gi, Park, Jin Hee, Lee, Lena S, Yoo, Zhan-Guo, Gao, Kenneth A, Jacobson, Lak Shin, Jeong
Publikováno v:
ACS medicinal chemistry letters. 2010(9)
The truncated C2- and C8-substituted-4'-thioadenosine derivatives 4a-d were synthesized from D-mannose, using palladium-catalyzed cross coupling reactions as key steps. In this study, an A(3) adenosine receptor (AR) antagonist, truncated 4'-thioadeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3531b4ce9394a5ea4aba23f4d4161035
https://pubmed.ncbi.nlm.nih.gov/21286238
https://pubmed.ncbi.nlm.nih.gov/21286238
Autor:
S. Michael Kilbey, T. Kendall Harden, Zhan-Guo Gao, Ingrid P. Fricks, Moshe Chinn, Kenneth A. Jacobson, Matthew O. Barrett, Dilip K. Tosh, Lena S. Yoo, Kunlun Hong
Publikováno v:
Bioconjugate chemistry. 21(2)
We previously synthesized a series of potent and selective A(3) adenosine receptor (AR) agonists (North-methanocarba nucleoside 5'-uronamides) containing dialkyne groups on extended adenine C2 substituents. We coupled the distal alkyne of a 2-octadiy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a0c4ea4afbadff7bf1b4bceedd85db
https://pubmed.ncbi.nlm.nih.gov/20121074
https://pubmed.ncbi.nlm.nih.gov/20121074