The E3 ubiquitin-protein ligase Nedd4-2 regulates the sodium chloride cotransporter (NCC) but is not required for a potassium-induced reduction of NCC expression

Autor: Lena Rosenbaek, Federica Petrillo, Miguel Van Bemmelen, Olivier Staub, Sathish Murali, Robert Fenton

Publikováno v: Rosenbaek, L, Petrillo, F, Van Bemmelen, M, Staub, O, Murali, S & Fenton, R 2022, ' The E3 ubiquitin-protein ligase Nedd4-2 regulates the sodium chloride cotransporter (NCC) but is not required for a potassium-induced reduction of NCC expression ', The FASEB Journal, vol. 36, no. S1 . https://doi.org/10.1096/fasebj.2022.36.S1.0R831

STUDY OBJECTIVE: The activity of the sodium chloride cotransporter (NCC) in the kidney distal convoluted is important for kidney sodium (Na+ ) and potassium (K+ ) handling. NCC abundance is reduced by high plasms K+ levels. The E3 ubiquitin ligase ne

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