Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation

Autor: Shaima’a Hamarsheh, Lena Osswald, Benedikt S. Saller, Susanne Unger, Donatella De Feo, Janaki Manoja Vinnakota, Martina Konantz, Franziska M. Uhl, Heiko Becker, Michael Lübbert, Khalid Shoumariyeh, Christoph Schürch, Geoffroy Andrieux, Nils Venhoff, Annette Schmitt-Graeff, Sandra Duquesne, Dietmar Pfeifer, Matthew A. Cooper, Claudia Lengerke, Melanie Boerries, Justus Duyster, Charlotte M. Niemeyer, Miriam Erlacher, Bruce R. Blazar, Burkard Becher, Olaf Groß, Tilman Brummer, Robert Zeiser

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

Oncogenic Ras mutations are common drivers in myeloid leukemia. Here, the authors show in patient cells and in mice that oncogenic K-Ras activates NLRP3 inflammasome to drive myeloproliferation, which can be reversed by genetic or pharmacologic NLRP3

Externí odkaz: https://doaj.org/article/8d60e15645a540748f0978aece6a6bc5

Supplementary Figures 1-7 from Oncogenic KrasG12D Activation in the Nonhematopoietic Bone Marrow Microenvironment Causes Myelodysplastic Syndrome in Mice

Autor: Robert Zeiser, Tilman Brummer, Melanie Boerries, Justus Duyster, Annette Schmitt-Graeff, Lukas M. Braun, Sandra Duquesne, Christine Dierks, Claudius Klein, Geoffroy Andrieux, Franziska Maria Uhl, Shaima'a Hamarsheh, Lena Osswald

S1. KrasG12D recipient mice develop a myelodysplastic syndrome within the transferred WT hematopoietic system. S2. Gating strategy used for the isolation of bone marrow (BM) niche cells. S3. The frequency of BM niche cells is not affected in KrasG12D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b3296df9d02a5d90b9267cc3fde8e8
https://doi.org/10.1158/1541-7786.22526058

Letermovir Prophylaxis for CMV Reactivation in Allogeneic Stem Cell Recipients: A Retrospective Single Center Analysis

Autor: KATRIN KOCH, LENA OSSWALD, ISABELLA MILLER, KRISCHAN BRAITSCH, KATHARINA GÖTZE, FLORIAN BASSERMANN, PETER HERHAUS, MAREIKE VERBEEK

Publikováno v: Anticancer research. 42(11)

Cytomegalovirus (CMV) reactivation is one of the most clinically significant complications in allogeneic stem cell recipients and a frequent cause for transplantation related mortality. Letermovir is a newly available and recently approved drug for C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34309d212d95b846c2d2e0656a0d190
https://pubmed.ncbi.nlm.nih.gov/36288861

Oncogenic

Autor: Lena, Osswald, Shaima'a, Hamarsheh, Franziska Maria, Uhl, Geoffroy, Andrieux, Claudius, Klein, Christine, Dierks, Sandra, Duquesne, Lukas M, Braun, Annette, Schmitt-Graeff, Justus, Duyster, Melanie, Boerries, Tilman, Brummer, Robert, Zeiser

Publikováno v: Molecular cancer research : MCR. 19(9)

The bone marrow microenvironment (BMME) is key player in regulation and maintenance of hematopoiesis. Oncogenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b0404e33a18bcb6e8a4ac5782c50ff5e
https://pubmed.ncbi.nlm.nih.gov/34088868

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Autor: Donald Bunjes, Sebastian Halbach, Dietmar Pfeifer, Philipp Hemmati, Robert S. Negrin, Fabio Ciceri, Jean-Yves Cahn, Markus Ditschkowski, Pavan Reddy, Kathrin Hanke, Daniela Dörfel, Susan Klaeger, Jürgen Finke, Zehan Hu, Gabriele Ihorst, Gérard Socié, Sanaz Taromi, Andreas Hochhaus, Glen A Kennedy, Omid Shah, Andreas Neubauer, Robert Thimme, Michael Schultheiss, Sabine Spath, Dietrich W. Beelen, Sandra Duquesne, Arnim Weber, Geoffrey R. Hill, Ronjon Chakraverty, Jürgen Kuball, Guido Kobbe, Nikolas von Bubnoff, Andrea S. Henden, Betul Oran, Burkhard Becher, Bernhard Kuster, Christoph Rummelt, Lena Osswald, Hartmut Bertz, Wolfgang Bethge, Eva-Maria Wagner, Arnon Nagler, Eliana Ruggiero, Saar Gill, Miguel Waterhouse, Andreas Mackensen, Dominik Bettinger, Francis Baumgartner, Florian Kuchenbauer, Anita Sarma, Takanori Teshima, Erika L. Pearce, Antonia M.S. Müller, Kathleen Stabla, John M. Magenau, Evelyn Ullrich, Nicolaus Kröger, Georg Häcker, Simone Thomas, Myriam Labopin, Ghulam J. Mufti, Jan E. Ehlert, Lutz P. Müller, Marie Follo, Dominik Wolf, Tony Andreas Müller, Michael Lübbert, Jacqueline Schnell, Christof Scheid, Takeshi Kondo, Donal P. McLornan, Thomas Pabst, Konrad Wilhelm, Chiara Bonini, Wolf Rösler, Simon Richardson, Cordula A. Jilg, Andrea Schmidts, Luca Vago, Joseph H. Antin, Annette Schmitt-Graeff, Yakup Tanriver, Michael A. Caligiuri, Wolfgang Herr, Kai-Li Yan, Lukas Braun, Daniel J. Weisdorf, Katayoun Rezvani, Giang Lam Vuong, Tilman Brummer, Stephan Meckel, Ralph Wäsch, Geoffroy Andrieux, Soroush Doostkam, Hauke Busch, Dennis Dong Hwan Kim, Sabine Gerull, Bruce R. Blazar, Robert Zeiser, Merav Bar, Flore Sicre-de-Fontbrune, Daniel Feger, Melanie Börries, Wolfgang Melchinger, Petya Apostolova, C. Leiber, Udo Holtick, Walter J.F.M. van der Velden, Renate Arnold, Rainer Claus, Justus Duyster, Nimitha R. Mathew, David O’Sullivan, Alexandros Spyridonidis, S K Metzelder, Thomas Schroeder, Jörg Halter, Johanna Haag, Friedrich Stölzel, Christoph Schmid, Anna Lena Illert, Claudia Lengerke, Björn Hackanson, Joern Dengjel, Francis Ayuk, Rainer Ordemann, Sonia Tugues, Marco Prinz, Inken Hilgendorf, Andreas Burchert

Publikováno v: Nature Medicine
Nature Medicine, 24, 282-291
Nature Medicine, 24, 3, pp. 282-291

Contains fulltext : 190745.pdf (Publisher’s version ) (Closed access) Individuals with acute myeloid leukemia (AML) harboring an internal tandem duplication (ITD) in the gene encoding Fms-related tyrosine kinase 3 (FLT3) who relapse after allogenei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683895fe6925b717745d389109e2d7ac