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Akademický článek

Large anatomical changes in head-and-neck cancers – A dosimetric comparison of online and offline adaptive proton therapy

Autor: Mislav Bobić, Arthur Lalonde, Konrad P. Nesteruk, Hoyeon Lee, Lena Nenoff, Bram L. Gorissen, Alejandro Bertolet, Paul M. Busse, Annie W. Chan, Brian A. Winey, Gregory C. Sharp, Joost M. Verburg, Antony J. Lomax, Harald Paganetti

Publikováno v: Clinical and Translational Radiation Oncology, Vol 40, Iss , Pp 100625- (2023)

Purpose: This work evaluates an online adaptive (OA) workflow for head-and-neck (H&N) intensity-modulated proton therapy (IMPT) and compares it with full offline replanning (FOR) in patients with large anatomical changes. Methods: IMPT treatment plan

Externí odkaz: https://doaj.org/article/647f303ef76648b6a2847d7b8bffa2e4

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Akademický článek

Correction of Geometrical Effects of a Knife-Edge Slit Camera for Prompt Gamma-Based Range Verification in Proton Therapy

Autor: Johannes Petzoldt, Guillaume Janssens, Lena Nenoff, Christian Richter, Julien Smeets

Publikováno v: Instruments, Vol 2, Iss 4, p 25 (2018)

Prompt gamma (PG) based range verification can potentially reduce the safety margins in proton therapy. A knife-edge slit camera has been developed in this context using analytical PG simulations as reference for absolute range verification during pa

Externí odkaz: https://doaj.org/article/02c7930a723842c8ba4d2495ab7f715c

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An approach for estimating dosimetric uncertainties in deformable dose accumulation in pencil beam scanning proton therapy for lung cancer

Autor: Francesca Albertini, Antony J. Lomax, Ye Zhang, Jan Unkelbach, Cássia O. Ribeiro, Lena Nenoff, Antje-Christin Knopf, Florian Amstutz, Damien C. Weber

Publikováno v: Physics in Medicine and Biology, 66(10):105007, 1-12. IOP PUBLISHING LTD

Background and purpose Deformable image registration (DIR) is an important component for dose accumulation and associated clinical outcome evaluation in radiotherapy. However, as an ill-posed problem, the resulting deformation vector field (DVF) is s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e303fc17ee0c2878f09f517dc53f3f6
https://doi.org/10.1088/1361-6560/abf8f5

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PO-1535 Deformable image registration uncertainty for dose accumulation of proton therapy for H&N tumors

Autor: A.J. Lomax, Yan-Lin Zhang, Francesca Albertini, F. Amstutz, Lena Nenoff, D.C. Weber, P.G. D’Almeida

Publikováno v: Radiotherapy and Oncology. 161:S1259-S1261

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96aabcfc8d8059f0dc4bbf73594dee47
https://doi.org/10.1016/s0167-8140(21)07986-x

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Deformable image registration uncertainty for inter-fractional dose accumulation of lung cancer proton therapy

Autor: Michael Matter, Antony J. Lomax, Lena Nenoff, Johannes A. Langendijk, Ye Zhang, Cássia O. Ribeiro, Luana Hafner, Mirjana Josipovic, Antje Knopf, Gitte F. Persson, M. Walser, Damien C. Weber, Francesca Albertini

Publikováno v: Radiotherapy and Oncology, 147, 178-185. ELSEVIER IRELAND LTD
Radiotherapy & Oncology, 147
Nenoff, L, Ribeiro, C O, Matter, M, Hafner, L, Josipovic, M, Langendijk, J A, Persson, G F, Walser, M, Weber, D C, Lomax, A J, Knopf, A C, Albertini, F & Zhang, Y 2020, ' Deformable image registration uncertainty for inter-fractional dose accumulation of lung cancer proton therapy ', Radiotherapy and Oncology, vol. 147, pp. 178-185 . https://doi.org/10.1016/j.radonc.2020.04.046

Background and purpose Non-small cell lung cancer (NSCLC) patients show typically large anatomical changes during treatment, making recalculation or adaption necessary. For report and review, the applied treatment dose can be accumulated on the refer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e140d84dd853b5cdd1ebce78c56d8f8d
https://doi.org/10.1016/j.radonc.2020.04.046

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TCP and NTCP Calculations Based on Treatment Doses Instead of Planned Doses for Daily Adaptive Proton Therapy of Lung Cancer

Autor: Francesca Albertini, Giovanni Fattori, Lena Nenoff, Mirjana Josipovic, Michael Matter, E.J. Amaya, Gitte F. Persson, M. Walser, A. Köthe, S. Visser, Damien C. Weber, Cássia O. Ribeiro, Yan-Lin Zhang, Anthony Lomax, Sairos Safai, Antje-Christin Knopf

Publikováno v: International Journal of Radiation Oncology Biology Physics, 111(3, supplement). ELSEVIER SCIENCE INC
Web of Science

Purpose/objective(s) Calculation of tumor control probability (TCP) and normal tissue complication probability (NTCP) is becoming increasingly relevant for optimizing treatment strategies, for example the selection of patients for proton therapy. Whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e69dc522e71f7d3271f927d8ed48a1
https://research.rug.nl/en/publications/8aefdeb6-2ea7-46b7-b989-3228b6704911

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Low-Dose Computed Tomography Scanning Protocols for Online Adaptive Proton Therapy of Head-and-Neck Cancers

Autor: Konrad P. Nesteruk, Mislav Bobić, Gregory C. Sharp, Arthur Lalonde, Brian A. Winey, Lena Nenoff, Antony J. Lomax, Harald Paganetti

Publikováno v: Cancers, 14 (20)
Cancers; Volume 14; Issue 20; Pages: 5155

Purpose: To evaluate the suitability of low-dose CT protocols for online plan adaptation of head-and-neck patients. Methods: We acquired CT scans of a head phantom with protocols corresponding to CT dose index volume CTDIvol in the range of 4.2–165

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c542b6be576b4fc707c5320d5b8820
https://doi.org/10.3390/cancers14205155

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Dosimetric influence of deformable image registration uncertainties on propagated structures for online daily adaptive proton therapy of lung cancer patients

Autor: Antony J. Lomax, Francesca Albertini, M. Walser, Gitte F. Persson, Mirjana Josipovic, Lena Nenoff, Enrique Javier Amaya, Damien C. Weber, S. Visser, Antje-Christin Knopf, Ye Zhang, Cássia O. Ribeiro, Michael Matter

Publikováno v: Radiotherapy & Oncology, 159
Nenoff, L, Matter, M, Amaya, E J, Josipovic, M, Knopf, A C, Lomax, A J, Persson, G F, Ribeiro, C O, Visser, S, Walser, M, Weber, D C, Zhang, Y & Albertini, F 2021, ' Dosimetric influence of deformable image registration uncertainties on propagated structures for online daily adaptive proton therapy of lung cancer patients ', Radiotherapy and Oncology, vol. 159, pp. 136-143 . https://doi.org/10.1016/j.radonc.2021.03.021
Nenoff, Lena; Matter, Michael; Amaya, Enrique Javier; Josipovic, Mirjana; Knopf, Antje-Christin; John Lomax, Antony; Persson, Gitte F; Ribeiro, Cássia O; Visser, Sabine; Walser, Marc; Weber, Damien Charles; Zhang, Ye; Albertini, Francesca (2021). Dosimetric influence of deformable image registration uncertainties on propagated structures for online daily adaptive proton therapy of lung cancer patients. Radiotherapy and oncology, 159, pp. 136-143. Elsevier 10.1016/j.radonc.2021.03.021
Radiotherapy and Oncology, 159, 136-143. ELSEVIER IRELAND LTD

Purpose A major burden of introducing an online daily adaptive proton therapy (DAPT) workflow is the time and resources needed to correct the daily propagated contours. In this study, we evaluated the dosimetric impact of neglecting the online correc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::accf7d6a7737b4587fa2d0c1e95e35f9
https://hdl.handle.net/20.500.11850/478765

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