Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lena Miloradovic"'
Autor:
Gregor Winkels, Juliet Quirk, Eugene Maraskovsky, Lauren Seddon, Lisa M. Ebert, Jonathan Cebon, Tsin Yee Tai, Leone Morris, Frederick Wittke, Weisan Chen, Ian D. Davis, Judy Browning, Genevieve Whitty, Duncan MacGregor, Lena Miloradovic, Tina Cavicchiolo, Regina Alex, Heather Jackson
Publikováno v:
Immunotherapy. 9(3)
Aim: Pilot clinical trial of NY-ESO-1 (ESO) protein in ISCOMATRIX™ adjuvant pulsed onto peripheral blood dendritic cells (PBDC), to ascertain feasibility, evaluate toxicity and assess induction of ESO-specific immune responses. Patients & methods:
Autor:
Ralph Venhaus, Ian D. Davis, Eric W. Hoffman, Wendie Hopkins, Nektaria Dimopoulos, Lena Miloradovic, Theo Nicholaou, Weisan Chen, Lisa M. Ebert, Bee Shin Tan, Linda Pan, Jonathan Cebon, Grant A. McArthur, Eugene Maraskovsky, Heather Jackson
Publikováno v:
Clinical Cancer Research. 15:2166-2173
Purpose: NY-ESO-1 is a highly immunogenic antigen expressed in a variety of malignancies, making it an excellent target for cancer vaccination. We recently developed a vaccine consisting of full-length recombinant NY-ESO-1 protein formulated with ISC
Autor:
Mark Rizkalla, Ian D. Davis, Heather Goldie, He-cheng Zhu, Simon Green, Phillip Parente, Lena Miloradovic, Lloyd J. Old, Wendie Hopkins, Nicole A. Mifsud, Nektaria Dimopoulos, Kelly-Anne Masterman, Weisan Chen, Jonathan Cebon, Tina Luke, Eugene Maraskovsky, Qiyuan Chen, James McCluskey, Heather Jackson, Tsin Yee Tai
Publikováno v:
Proceedings of the National Academy of Sciences. 101:9363-9368
There is increasing evidence showing the involvement of CD4 + T cells in initiating and maintaining antitumor immune responses. NY-ESO-1 is expressed by various tumors but not normal tissues except testis. We conducted a cancer clinical trial by usin
Publikováno v:
Biologicals. 28:169-174
The manufacturing process in Australia for equine antisera against various venoms/toxins is based primarily on ammonium sulphate precipitation of pepsin-digested IgG, whereby Fc and F(ab)2 fragments are separated. The capacity of the process to remov
Autor:
Weisan Chen, Jonathan Cebon, Ken Shortman, Eugene Maraskovsky, Jose A Villadangos, Simon Green, Debbie Drane, Qiyuan Chen, Ian D. Davis, Lena Miloradovic, Corinna Jenderek, Amanda Shin, Max Schnurr, Tracey Toy
Publikováno v:
Blood. 105(6)
Dendritic cells (DCs) are being evaluated for cancer immunotherapy due to their unique ability to induce tumor-directed T-cell responses. Here we report that the type of human DC, the mode of activation, and the strategy for delivery of antigen are 3
Autor:
Jonathan Cebon, Grant A. McArthur, Simon Green, Ian D. Davis, Andrew Cuthbertson, Achim A. Jungbluth, Duncan MacGregor, Sacha Gnjatic, Susan V. Mitchell, Yao-Tseng Chen, Wendie Hopkins, Darryl W. Maher, Gerd Ritter, Roger Murphy, Andrew M. Scott, Sue Sturrock, Nektaria Dimopoulos, Tina Luke, Tsin Yee Tai, Heather Jackson, Lena Miloradovic, Weisan Chen, Eugene Maraskovsky, Eric W. Hoffman, Qiyuan Chen, Phillip Parente, Mark Shackleton, Lloyd J. Old
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 101(29)
NY-ESO-1 is a “cancer-testis” antigen expressed in many cancers. ISCOMATRIX is a saponin-based adjuvant that induces antibody and T cell responses. We performed a placebo-controlled clinical trial evaluating the safety and immunogenicity of recom
Autor:
L. J. Old, Linda S. Pan, Lena Miloradovic, Theo Nicholaou, Weisan Chen, Jonathan Cebon, Grant A. McArthur, E. Marakovsky, W. Hopkins, Eric W. Hoffman, Ian D. Davis
Publikováno v:
Journal of Clinical Oncology. 24:2571-2571
2571 Background: NY-ESO-1 is an immunogenic “cancer-testis” (CT) antigen, expressed in many cancers including melanoma. Iscomatrix adjuvant (IMX), a saponin-based adjuvant, was formulated with NY-ESO-1 (ESO) protein (ESO/IMX). ESO/IMX was highly
Systematic Analysis of Anti-NY-ESO-1 T Cell Responses Reveals Striking HLA-Dependent Immunodominance
Autor:
Qiyuan Chen, Heather Jackson, Tsin Yee Tai, Eugene Maraskovsky, Jonathan Cebon, Nicole A. Mifsud, Nektaria Dimopoulos, Weisan Chen, Lena Miloradovic, Ian D. Davis, Immanuel F. Luescher, Lloyd J. Old
Publikováno v:
Journal of Immunotherapy. 28:629
Autor:
Darryl W. Maher, Simon Green, Yao-Tseng Chen, Roger Murphy, Sue Sturrock, Tina Luke, Eugene Maraskovsky, Duncan MacGregor, Andrew Cuthbertson, Ian D. Davis, Achim A. Jungbluth, Sacha Gnjatic, Jonathan Cebon, Tsin Yee Tai, Grant A. McArthur, Gerd Ritter, Heather Jackson, Eric W. Hoffman, Andrew M. Scott, Susan V. Mitchell, Lloyd J. Old, Mark Shackleton, Phillip Parente, Weisan Chen, Wendie Hopkins, Nektaria Dimopoulos, Qiyuan Chen, Lena Miloradovic
Publikováno v:
Proceedings of the National Academy of Sciences. 102:9734-9734