Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lena M. Berger"'
Autor:
Martin P. Schwalm, Lena M. Berger, Maximilian N. Meuter, James D. Vasta, Cesear R. Corona, Sandra Röhm, Benedict-Tilman Berger, Frederic Farges, Sebastian M. Beinert, Franziska Preuss, Viktoria Morasch, Vladimir V. Rogov, Sebastian Mathea, Krishna Saxena, Matthew B. Robers, Susanne Müller, Stefan Knapp
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
E3 ligases constitute a large and diverse family of proteins that play a central role in regulating protein homeostasis by recruiting substrate proteins via recruitment domains to the proteasomal degradation machinery. Small molecules can either inhi
Externí odkaz:
https://doaj.org/article/bc038599fbfd4e358a76cbc206775e95
Autor:
Matthew B. Robers, Jennifer M. Wilkinson, James D. Vasta, Lena M. Berger, Benedict-Tilman Berger, Stefan Knapp
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100822- (2021)
Summary: This protocol is used to profile the engagement of kinase inhibitors across nearly 200 kinases in a live-cell context. This protocol utilizes one single kinase tracer (NanoBRET(TM) Tracer K10) that operates quantitatively at four different c
Externí odkaz:
https://doaj.org/article/751fa5ff2d3441ebaf399265a1e71e7a
Autor:
Marcel Rak, Roberta Tesch, Lena M. Berger, Ekaterina Shevchenko, Monika Raab, Amelie Tjaden, Rezart Zhubi, Dimitrios-Ilias Balourdas, Andreas C. Joerger, Antti Poso, Andreas Krämer, Lewis Elson, Aleksandar Lučić, Thales Kronenberger, Thomas Hanke, Klaus Strebhardt, Mourad Sanhaji, Stefan Knapp
Salt-inducible kinases 1-3 (SIK1-3) are key regulators of the LKB1-AMPK pathway and play an important role in cellular homeostasis. Dysregulation of any of the three isoforms has been associated with tumorigenesis in liver, breast, and ovarian cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464dad30e9b231cf6faf66b9ea226da4
https://doi.org/10.1101/2023.03.24.534094
https://doi.org/10.1101/2023.03.24.534094
Autor:
Michael J. Eck, Stefan Laufer, Bo Hee Shin, Stefan Knapp, Pasi A. Jänne, David E. Heppner, Anna M Schmoker, Matthew B. Robers, Tyler S. Beyett, James D Vasta, Ciric To, Nicolas Bauer, Jaimin K. Rana, Cesear Corona, Marcel Günther, Lena M. Berger, Florian Wittlinger, Benedict-Tilman Berger
Publikováno v:
Journal of Medicinal Chemistry. 65:1370-1383
Inhibitors targeting the epidermal growth factor receptor (EGFR) are an effective therapy for patients with non-small cell lung cancer harboring drug-sensitive activating mutations in the EGFR kinase domain. Drug resistance due to treatment-acquired
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60cdfff3107b6d5a3ce0d8c8e48c4550
https://doi.org/10.1021/acs.jmedchem.1c00848
https://doi.org/10.1021/acs.jmedchem.1c00848
Autor:
Lena M. Berger, Benedict-Tilman Berger, Andreas C. Joerger, Thomas Hanke, Antti Poso, Monika Raab, Stefan Knapp, Ismahan Abdi, Marcel Rak, Thales Kronenberger, Mourad Sanhaji, Klaus Strebhardt, Roberta Tesch
Publikováno v:
Journal of Medicinal Chemistry. 64:8142-8160
Salt-inducible kinases (SIKs) are key metabolic regulators. The imbalance in SIK function is associated with the development of diverse cancers, including breast, gastric, and ovarian cancers. Chemical tools to clarify the roles of SIK in different d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f574c43602acdc1e5e6a813520b61dc7
https://doi.org/10.1021/acs.jmedchem.0c02144
https://doi.org/10.1021/acs.jmedchem.0c02144
Autor:
Julian Laux, Michael Forster, Laura Riexinger, Anna Schwamborn, Jamil Guezguez, Christina Pokoj, Mark Kudolo, Lena M. Berger, Stefan Knapp, Dieter Schollmeyer, Jan Guse, Michael Burnet, Stefan A. Laufer
Publikováno v:
ACS pharmacologytranslational science. 5(8)
Modulation of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling is a promising method of treating autoimmune diseases, and the profound potency of clinical compounds makes this mode of action particularly attractive.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6482181afcf1f1295ee7e4c7a8627206
https://pubmed.ncbi.nlm.nih.gov/35983274
https://pubmed.ncbi.nlm.nih.gov/35983274
Autor:
Allison S. Limpert, Lena M. Berger, Stefan Knapp, Lester J. Lambert, Nicholas D. P. Cosford, Fabiana I.A.L. Layng, Apirat Chaikuad, Cunxiang Yuan, Jing Dong, Li Wang, Maria Celeridad, Yi Peng, Douglas J. Sheffler, Nicole Bata, Guoxiong Liu, Nicole A Bakas
Publikováno v:
J Med Chem
Serine/threonine-protein kinases 3 and 4 (STK3 and STK4, respectively) are key components of the Hippo signaling pathway, which regulates cell proliferation and death and provides a potential therapeutic target for acute myeloid leukemia (AML). Herei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc05bd607eb905af295851148fa0764
https://europepmc.org/articles/PMC10149138/
https://europepmc.org/articles/PMC10149138/
Autor:
N. Berner, Magda Szewczyk, B. Kuester, J. Weckesser, Martin Eilers, Andreas Kraemer, Christoph A. Sotriffer, Volker Doetsch, Bikash Adhikari, Frank Loehr, Stephanie Heinzlmeir, Dalia Barsyte-Lovejoy, A. Doelle, Mathias Diebold, Elmar Wolf, J. Gerbel, Lena M. Berger, Stefan Knapp, Cheryl H. Arrowsmith
Histone H3K4 methylation serves as post-translational hallmark of actively transcribed genes and is introduced by histone methyltransferases (HMT) and its regulatory scaffolding proteins. One of these is the WD-repeat containing protein 5 (WDR5) that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bb60d0d7a9cb8061918d0989716e03b
https://doi.org/10.1101/2021.04.12.439490
https://doi.org/10.1101/2021.04.12.439490
Autor:
Ismahan Abdi, Andreas C. Joerger, Stefan Knapp, Lena M. Berger, Antti Poso, Klaus Strebhardt, Benedict-Tilman Berger, Monika Raab, Marcel Rak, Thales Kronenberger, Mourad Sanhaji, Thomas Hanke, Roberta Tesch
Salt-inducible kinases (SIKs) are key metabolic regulators. Imbalance of SIK function is associated with the development of diverse cancers, including breast, gastric and ovarian cancer. Chemical tools to clarify the roles of SIK in different disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65d4bcf99791aede52931a3fe406dd4f
https://doi.org/10.1101/2021.04.08.439011
https://doi.org/10.1101/2021.04.08.439011
Autor:
Silvia Rösser, Iris Bischoff-Kont, L Mittmann, Lena M. Berger, Franz Bracher, Stefan Knapp, Thomas Zech, Robert Fürst, Benjamin Strödke, G Melissa Krishnathas, Tobias Schmid, Susanne Müller, Christoph A. Reichel
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(6)
Chronic inflammation-related diseases are characterized by persistent leukocyte infiltration into the underlying tissue. The vascular endothelium plays a major role in this pathophysiological condition. Only few therapeutic strategies focus on the va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc62678fcdc47e7fe597b573eccffd2
https://pubmed.ncbi.nlm.nih.gov/34042211
https://pubmed.ncbi.nlm.nih.gov/34042211