Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lena Lapkina-Gendler"'
Autor:
Rand Shibel, Rive Sarfstein, Karthik Nagaraj, Lena Lapkina-Gendler, Zvi Laron, Manisha Dixit, Shoshana Yakar, Haim Werner
Publikováno v:
Cells, Vol 10, Iss 6, p 1483 (2021)
Endometrial cancer is the most common gynecologic malignancy in Western countries. The insulin-like growth factor-1 (IGF1) axis has an important role in endometrial cancer biology and emerged as a promising therapeutic target in oncology. However, th
Externí odkaz:
https://doaj.org/article/3d5acbacd8e84b5ebeb88f5e8d8ed1f4
Autor:
Haim Werner, Lena Lapkina-Gendler, Laris Achlaug, Karthik Nagaraj, Lina Somri, Danielle Yaron-Saminsky, Metsada Pasmanik-Chor, Rive Sarfstein, Zvi Laron, Shoshana Yakar
Publikováno v:
Cells, Vol 8, Iss 6, p 596 (2019)
Laron syndrome (LS), or primary growth hormone resistance, is a prototypical congenital insulin-like growth factor 1 (IGF1) deficiency. The recent epidemiological finding that LS patients do not develop cancer is of major scientific and clinical rele
Externí odkaz:
https://doaj.org/article/1cc8c0e9c5d54fddab17357e9c9106eb
Publikováno v:
European Journal of Cancer. 141:115-127
Introduction The growth hormone (GH)-insulin-like growth factor-1 (IGF1) endocrine axis has a key role in normal growth and development. Laron syndrome (LS) is a type of dwarfism that results from mutation of the GH receptor, leading to congenital IG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a846c630259bdc3f23e6c6c82e66d4
https://doi.org/10.1016/j.ejca.2020.09.034
https://doi.org/10.1016/j.ejca.2020.09.034
Autor:
Lena Lapkina-Gendler, Haim Werner, Zvi Laron, Lina Somri, Karthik Nagaraj, Rive Sarfstein, Leon A. Bach
Publikováno v:
Growth Hormone & IGF Research. 39:6-12
Laron syndrome (LS), or primary growth hormone (GH) insensitivity, is a growth disorder that results from mutation of the GH-receptor (GHR) gene leading to congenital insulin-like growth factor-1 (IGF-1) deficiency. Recent epidemiological studies hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561210506317e3b7f3d132510ae158e9
https://doi.org/10.1016/j.ghir.2017.11.004
https://doi.org/10.1016/j.ghir.2017.11.004
Autor:
Lena Lapkina-Gendler, Metsada Pasmanik-Chor, Karthik Nagaraj, Zvi Laron, Shoshana Yakar, Haim Werner, David Gurwitz, Rive Sarfstein
Publikováno v:
Proceedings of the National Academy of Sciences. 115:1045-1050
Laron syndrome (LS), or primary growth hormone (GH) insensitivity, is the best-characterized entity among the congenital insulin-like growth factor 1 (IGF1) deficiencies. Life-long exposure to minute endogenous IGF1 levels is linked to low stature as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c455fa8f81b48242d1f3b2e87569eaf
https://doi.org/10.1073/pnas.1715930115
https://doi.org/10.1073/pnas.1715930115
Publikováno v:
European Journal of Cancer. 148:453-454
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::794696d24ff09001ac31e18851792e00
https://doi.org/10.1016/j.ejca.2021.02.014
https://doi.org/10.1016/j.ejca.2021.02.014
Autor:
Zvi Laron, Haim Werner, Shoshana Yakar, Manisha Dixit, Karthik Nagaraj, Lena Lapkina-Gendler, Rive Sarfstein, Rand Shibel
Publikováno v:
Cells
Volume 10
Issue 6
Cells, Vol 10, Iss 1483, p 1483 (2021)
Volume 10
Issue 6
Cells, Vol 10, Iss 1483, p 1483 (2021)
Endometrial cancer is the most common gynecologic malignancy in Western countries. The insulin-like growth factor-1 (IGF1) axis has an important role in endometrial cancer biology and emerged as a promising therapeutic target in oncology. However, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d2290cb4197b01fa7c84c866cf1947
https://doi.org/10.3390/cells10061483
https://doi.org/10.3390/cells10061483
Autor:
Rive Sarfstein, Zvi Laron, Lena Lapkina-Gendler, David Gurwitz, Itai Rotem, Metsada Pasmanik-Chor, Haim Werner
Publikováno v:
Endocrine-Related Cancer. 23:399-410
The growth hormone (GH)–insulin-like growth factor-1 (IGF1) pathway emerged in recent years as a critical player in cancer biology. Enhanced expression or activation of specific components of the GH–IGF1 axis, including the IGF1 receptor (IGF1R),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9a410830d00f97ca8d577b5d605640
https://doi.org/10.1530/erc-16-0054
https://doi.org/10.1530/erc-16-0054
Publikováno v:
Translational Medicine Reports. 1
Laron syndrome (LS) is a rare genetic disorder identified in the 1950s by Professor Zvi Laron. LS results from mutation of the growth hormone receptor (GH-R) gene, leading to congenital insulin-like growth factor-1 (IGF1) deficiency and dwarfism. Rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::054d9b3a3b5059d3f803ed0f9438ef3c
https://doi.org/10.4081/tmr.6657
https://doi.org/10.4081/tmr.6657
Publikováno v:
The Israel Medical Association journal : IMAJ. 19(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba51b9beb6ab0d87fb1730106125ee46
https://pubmed.ncbi.nlm.nih.gov/28457105
https://pubmed.ncbi.nlm.nih.gov/28457105