Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lena Kogai"'
Autor:
Angelina Pakhomova, Olga Pershina, Pavel Bochkov, Natalia Ermakova, Edgar Pan, Lubov Sandrikina, Yulia Dagil, Lena Kogai, Wolf-Dieter Grimm, Mariia Zhukova, Sergey Avdeev
Publikováno v:
Life, Vol 13, Iss 9, p 1932 (2023)
Idiopathic pulmonary fibrosis (IPF) is one of the most common forms of interstitial lung disease, characterized by progressive parenchymal fibrosis and respiratory failure. In a model of bleomycin-induced pulmonary fibrosis, the antifibrotic and anti
Externí odkaz:
https://doaj.org/article/859f369d93d44876bfa9a90518d7e560
Publikováno v:
Medical Sciences Forum, Vol 21, Iss 1, p 4 (2023)
The survival and cytotoxicity of reprogrammed human CD8+ T-cells (hrT-cells) were evaluated in a culture of cancer stem cells (CSCs) isolated from a patient with small-cell lung cancer (SCLC). T-cells were isolated from the blood of healthy volunteer
Externí odkaz:
https://doaj.org/article/4868adaffcd540cda476330b06038e53
Autor:
Evgenii G. Skurikhin, Olga Pershina, Mariia Zhukova, Angelina Pakhomova, Natalia Ermakova, Darius Widera, Edgar Pan, Lubov Sandrikina, Lena Kogai, Nikolai Kushlinskii, Sergey Morozov, Aslan Kubatiev, Alexander Dygai
Publikováno v:
Medical Sciences Forum, Vol 21, Iss 1, p 40 (2023)
We have developed an approach to reprogramming immune cells by inhibiting the MAPK/ERK pathway through MEKi and the PD-1/PD-L1 immune checkpoint signaling pathway. We hypothesized that reprogramming of spleen CD8+ T-cells could also create a populati
Externí odkaz:
https://doaj.org/article/bb9ba8d48c7a45bb97bd5b376549c677
Autor:
Evgenii G. Skurikhin, Olga Pershina, Natalia Ermakova, Angelina Pakhomova, Mariia Zhukova, Edgar Pan, Lubov Sandrikina, Darius Widera, Lena Kogai, Nikolai Kushlinskii, Aslan Kubatiev, Sergey G. Morozov, Alexander Dygai
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15780 (2022)
Using a model of Lewis lung carcinoma (LLC) in vitro and in vivo, we previously demonstrated increased antitumor activity in CD8+ T-cells reprogrammed with an MEK inhibitor and PD-1 blocker. In this follow-up study, we carried out the reprogramming o
Externí odkaz:
https://doaj.org/article/df276f7f78f145a089c0f8233fdfcc6f
Autor:
Evgenii G. Skurikhin, Natalia Ermakova, Mariia Zhukova, Olga Pershina, Edgar Pan, Angelina Pakhomova, Lena Kogai, Victor Goldberg, Elena Simolina, Victoria Skurikhina, Darius Widera, Aslan Kubatiev, Sergey G. Morozov, Nikolai Kushlinskii, Alexander Dygai
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10853 (2022)
Current methods for diagnosis and treatment of small cell lung cancer (SCLC) have only a modest efficacy. In this pilot study, we analyzed circulating tumor cells (CTCs) and cancer stem cells (CSCs) in patients with SCLC to search for new diagnostic
Externí odkaz:
https://doaj.org/article/ae3a008b226e45858f25943586754ba8
Autor:
Evgenii G. Skurikhin, Olga Pershina, Natalia Ermakova, Angelina Pakhomova, Darius Widera, Mariia Zhukova, Edgar Pan, Lubov Sandrikina, Lena Kogai, Nikolai Kushlinskii, Sergey G. Morozov, Aslan Kubatiev, Alexander Dygai
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1450 (2022)
CD8+ T-lymphocytes play a key role in antitumor immune response. Patients with lung cancer often suffer from T-lymphocyte dysfunction and low T-cell counts. The exhaustion of effector T-lymphocytes largely limits the effectiveness of therapy. In this
Externí odkaz:
https://doaj.org/article/1793dad86e2f4025a71011239a194a65
Autor:
Evgenii G, Skurikhin, Olga, Pershina, Natalia, Ermakova, Angelina, Pakhomova, Darius, Widera, Mariia, Zhukova, Edgar, Pan, Lubov, Sandrikina, Lena, Kogai, Nikolai, Kushlinskii, Sergey G, Morozov, Aslan, Kubatiev, Alexander, Dygai
Publikováno v:
Biomedicines. 10(6)
CD8