JNK signaling prevents biliary cyst formation through a CASPASE-8–dependent function of RIPK1 during aging

Autor: Thomas Longerich, Mihael Vucur, Hanna Honcharova-Biletska, Johannes Schmitt, Nadine T. Gaisa, Verena Keitel, Frank Tacke, Sarah Comtesse, Lena Küsgens, Mathias Heikenwalder, Roger J. Davis, Christoph Roderburg, Peter Boor, Marc E. Healy, Marta Szydlowska, Lap Kwan Chan, Enrico Focaccia, Mirco Castoldi, Achim Weber, Christian Preisinger, Tom Luedde, Friederike Böhm, Michèle Egger, Fabian Geisler, Simone Jörs, Anne T. Schneider, Yannick Boege, Katrin Müller, Johannes G. Bode, Christiane Koppe, Sven H. Loosen

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America 118(12), e2007194118 (2021). doi:10.1073/pnas.2007194118
Proceedings of the National Academy of Sciences

Significance JNK signaling has been studied intensively in models of liver physiology and disease, but previous studies had focused on young mice. However, it had not been recognized that JNK plays a fundamental role in maintaining liver homeostasis

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https://mediatum.ub.tum.de/doc/1637116/document.pdf