Výsledky vyhledávání - "Lena Joesch-Cohen"

Akademický článek

Targeting NHE6 gene expression identifies lysosome and neurodevelopmental mechanisms in a haploid in vitro cell model

Autor: Qing Wu, Li Ma, Lena Joesch-Cohen, Michael Schmidt, Ece D. Gamsiz Uzun, Eric M. Morrow

Publikováno v: Biology Open, Vol 12, Iss 11 (2023)

Externí odkaz: https://doaj.org/article/44b3ccecd30a4546bf07a5ef9a3d4110

Copper induces cell death by targeting lipoylated TCA cycle proteins

Autor: Peter Tsvetkov, Shannon Coy, Boryana Petrova, Margaret Dreishpoon, Ana Verma, Mai Abdusamad, Jordan Rossen, Lena Joesch-Cohen, Ranad Humeidi, Ryan D. Spangler, John K. Eaton, Evgeni Frenkel, Mustafa Kocak, Steven M. Corsello, Svetlana Lutsenko, Naama Kanarek, Sandro Santagata, Todd R. Golub

Publikováno v: Science

Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How excess copper induces cell death, however, is unknown. Here, we show i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823d9210499ec728084765ef9240f1cb
https://europepmc.org/articles/PMC9273333/

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Methionine synthase is essential for cancer cell proliferation in physiological folate environments

Autor: Mark R. Sullivan, Daniel Rosenberg, Ahmed Ali, Jennifer Roth, Caroline A. Lewis, Tenzin Kunchok, Matthew G. Rees, Lena Joesch-Cohen, Matthew G. Vander Heiden, Alicia M. Darnell, Montana F. Reilly

Publikováno v: Nat Metab

Folate metabolism can be an effective target for cancer treatment. However, standard cell culture conditions utilize folic acid, a non-physiological folate source for most tissues. We find that the enzyme that couples folate and methionine metabolic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056548794ead8453d0f3dcee55fba032
https://pubmed.ncbi.nlm.nih.gov/34799701

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Functional Assessment

Autor: Qing, Ouyang, Lena, Joesch-Cohen, Sasmita, Mishra, Hasib A, Riaz, Michael, Schmidt, Eric M, Morrow

Publikováno v: eNeuro

Christianson syndrome (CS) is an X-linked neurogenetic disorder resulting from loss-of-function (LoF) mutations in SLC9A6, which encodes the endosomal Na+/H+ exchanger 6 (NHE6). NHE6 regulates proton efflux from endosomes and, thus, participates in r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ff80f12fcee74c228cfab869af5c9fe
https://pubmed.ncbi.nlm.nih.gov/31676550

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