Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lena Ilan"'
Autor:
Raymond Kaempfer, Lena Ilan, Smadar Cohen-Chalamish, Orli Turgeman, Lise Sarah Namer, Farhat Osman
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
A critical step in the cellular stress response is transient activation of the RNA-dependent protein kinase PKR by double-helical RNA, resulting in down-regulation of protein synthesis through phosphorylation of the α chain of translation initiation
Externí odkaz:
https://doaj.org/article/64d3508dcf124420accf8e6bb274fa61
Autor:
Shulamit Sebban, Marganit Farago, Dan Gashai, Lena Ilan, Eli Pikarsky, Ittai Ben-Porath, Shulamit Katzav
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54321 (2013)
Vav1 functions as a signal transducer protein in the hematopoietic system, where it is exclusively expressed. Vav1 was recently implicated in several human cancers, including lung, pancreatic and neuroblasoma. In this study, we analyzed the expressio
Externí odkaz:
https://doaj.org/article/6ee1bc5e4a934a32b69c3d0f3d840105
Autor:
Lena Ilan, Shulamit Katzav
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29939 (2012)
Vav1 is a signal transducer protein that functions as a guanine nucleotide exchange factor for the Rho/Rac GTPases in the hematopoietic system where it is exclusively expressed. Recently, Vav1 was shown to be involved in several human malignancies in
Externí odkaz:
https://doaj.org/article/75b8defdede2484b9634976444e3e193
Autor:
Nevraj S Kejiou, Lena Ilan, Stefan Aigner, Enching Luo, Tori Tonn, Hakan Ozadam, Muyoung Lee, Gregory B Cole, Ines Rabano, Nishani Rajakulendran, Brian A Yee, Hamed S Najafabadi, Trevor F Moraes, Stephane Angers, Gene W Yeo, Can Cenik, Alexander F Palazzo
Publikováno v:
Nucleic Acids Research.
In light of the numerous studies identifying post-transcriptional regulators on the surface of the endoplasmic reticulum (ER), we asked whether there are factors that regulate compartment specific mRNA translation in human cells. Using a proteomic su
Autor:
Farhat Osman, Lena Ilan, Lise Sarah Namer, Einav Eliahu, Smadar Cohen-Chalamish, Raymond Kaempfer, Yona Banai, Yitzhak Ben-Asouli
Publikováno v:
Cell Research. 27:688-704
Short elements in mammalian mRNA can control gene expression by activating the RNA-dependent protein kinase PKR that attenuates translation by phosphorylating cytoplasmic eukaryotic initiation factor 2α (eIF2α). We demonstrate a novel, positive rol
Autor:
Nishani Rajakulendran, Gene W. Yeo, Stephane Angers, Nevraj S. Kejiou, Lena Ilan, Stefan Aigner, En-Ching Luo, Ines Rabano, Alexander F. Palazzo, Hamed S. Najafabadi
How human cells coordinate various metabolic processes, such as glycolysis and protein translation, remains unclear. One key insight is that various metabolic enzymes have been found to associate with mRNAs, however whether these enzymes regulate mRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd60a268e230306a8eea30ac543cfeb
https://doi.org/10.1101/715086
https://doi.org/10.1101/715086
Autor:
Lise Sarah Namer, Lena Ilan, Raymond Kaempfer, Orli Turgeman, Farhat Osman, Smadar Cohen-Chalamish
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Frontiers in Genetics
Frontiers in Genetics
A critical step in the cellular stress response is transient activation of the RNA-dependent protein kinase PKR by double-helical RNA, resulting in down-regulation of protein synthesis through phosphorylation of the α chain of translation initiation
Publikováno v:
The international journal of biochemistrycell biology. 105
Once activated by double-helical RNA, mammalian RNA-dependent stress protein kinase, PKR, phosphorylates its substrate, translation initiation factor eIF2α, to inhibit translation. eIF2α phosphorylation is critical for mounting a cellular stress re
Autor:
Shulamit Sebban, Marganit Farago, Eli Pikarsky, Lena Ilan, Shiran Rabinovich, Yulia Idelchuck, Galit Lazer, Shulamit Katzav
Publikováno v:
Oncotarget
Vav1 is a signal transducer that functions as a scaffold protein and a regulator of cytoskeleton organization in the hematopoietic system, where it is exclusively expressed. Recently, Vav1 was shown to be involved in diverse human cancers, including
Autor:
Amos Panet, Lena Ilan, Yair Edden, Dror Kolodkin-Gal, Z Hartshtark, Samuel D. Rabkin, Alon J. Pikarsky, A Khalaileh, G Zamir, Eli Pikarsky
Publikováno v:
Gene Therapy. 16:905-915
Cancer of the rectum poses a complex therapeutic challenge because of its proximity to adjacent organs and anal sphincters. The addition of radiotherapy before surgical resection has been shown to confer good survival rates while preserving sphincter