Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lena Holembowski"'
Autor:
Antje, Repenning, Daniela, Happel, Caroline, Bouchard, Marion, Meixner, Yesim, Verel-Yilmaz, Hartmann, Raifer, Lena, Holembowski, Eberhard, Krause, Elisabeth, Kremmer, Regina, Feederle, Corinna U, Keber, Michael, Lohoff, Emily P, Slater, Detlef K, Bartsch, Uta-Maria, Bauer
Publikováno v:
The EMBO Journal
The p14ARF protein is a well‐known regulator of p53‐dependent and p53‐independent tumor‐suppressive activities. In unstressed cells, p14ARF is predominantly sequestered in the nucleoli, bound to its nucleolar interaction partner NPM. Upon gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a9ac4672694ac9be6c142205f0e775db
https://pubmed.ncbi.nlm.nih.gov/33999432
https://pubmed.ncbi.nlm.nih.gov/33999432
Autor:
Marion Meixner, Yesim Verel-Yilmaz, Regina Feederle, Eberhard Krause, Uta-Maria Bauer, Daniela Happel, Detlef K. Bartsch, Hartmann Raifer, Lena Holembowski, Michael Lohoff, Corinna U Keber, Emily P. Slater, Elisabeth Kremmer, Caroline Bouchard, Antje Repenning
Publikováno v:
EMBO J., e106777 (2021)
The p14 protein is a well-known regulator of p53-dependent and p53-independent tumor-suppressive activities. In unstressed cells, p14 is predominantly sequestered in the nucleoli, bound to its nucleolar interaction partner NPM. Upon genotoxic stress,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7633d0298a57ef40e7254d4b0674b6a9
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=62056
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=62056
Autor:
Ariel B. Abraham, Lena Holembowski, Ute M. Moll, Angelina V. Vaseva, Stella E. Tsirka, D Bode, W Brück, Andreas H. Scheel, Flaminia Talos, Matthias Dobbelstein
Publikováno v:
Cell Death & Differentiation. 17:1816-1829
The p53 family member p73 is essential for brain development, but its precise role and scope remain unclear. Global p73 deficiency determines an overt and highly penetrant brain phenotype marked by cortical hypoplasia with ensuing hydrocephalus and h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18619b6b560c039a2683c4059709f353
https://doi.org/10.1038/cdd.2010.131
https://doi.org/10.1038/cdd.2010.131
Autor:
Ute M. Moll, Lena Holembowski, Matthias Dobbelstein, Dietmar Riedel, Daniela Kramer, Raffaella Sordella, Alice Nemajerova
Publikováno v:
Journal of Cell Biology
The Journal of Cell Biology
The Journal of Cell Biology
The p53 family member TAp73 is required for sperm maturation through promotion of adhesion between developing germ cells and Sertoli nurse cells.
A core evolutionary function of the p53 family is to protect the genomic integrity of gametes. Howe
A core evolutionary function of the p53 family is to protect the genomic integrity of gametes. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb9fef71ee97afec3aa322b01911b0a
https://hdl.handle.net/11858/00-001M-0000-0019-772F-F11858/00-001M-0000-0019-7737-C11858/00-001M-0000-0019-7735-0
https://hdl.handle.net/11858/00-001M-0000-0019-772F-F11858/00-001M-0000-0019-7737-C11858/00-001M-0000-0019-7735-0
Autor:
Lena Holembowski, Ute M. Moll, Flaminia Talos, Ramona Schulz, Matthias Dobbelstein, Andreas H. Scheel, Sonja Wolff
Publikováno v:
Cell cycle (Georgetown, Tex.). 10(4)
The ancient p53 paralogs p63 and p73 regulate specific tissue formation, cell survival and cell death via their TA and ΔN isoforms. Targeted disruption of the p73 locus leads to severe defects in the development of the central nervous system (CNS),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a05ce86b9582b891602bf7fad022a05
https://pubmed.ncbi.nlm.nih.gov/21460637
https://pubmed.ncbi.nlm.nih.gov/21460637
Autor:
Lena Holembowski, Ute M. Moll, Gunter Fingerle-Rowson, Ramona Schulz, Marina Pesic, Lars Zender, Natalia D. Marchenko, Matthias Dobbelstein
Publikováno v:
The Journal of Experimental Medicine
In several human cancer cell lines, HSP90 inhibitors destabilize macrophage inhibitory factor protein; systemic treatment with an HSP90 inhibitor slows tumor growth and extends overall survival in a mouse model of HER2-positive human breast cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9e1d336dfeca8f26e3c77041ff20b3
https://doi.org/10.1084/jem.201111172093c
https://doi.org/10.1084/jem.201111172093c