Zobrazeno 1 - 10
of 300
pro vyhledávání: '"Lena Claesson-Welsh"'
Autor:
Elin Sjöberg, Marit Melssen, Mark Richards, Yindi Ding, Catarina Chanoca, Dongying Chen, Emmanuel Nwadozi, Sagnik Pal, Dominic T. Love, Takeshi Ninchoji, Masabumi Shibuya, Michael Simons, Anna Dimberg, Lena Claesson-Welsh
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 20 (2023)
Endothelial phospholipase Cγ (PLCγ) is essential for vascular development; however, its role in healthy, mature, or pathological vessels is unexplored. Here, we show that PLCγ was prominently expressed in vessels of several human cancer forms, not
Externí odkaz:
https://doaj.org/article/7698f966a69a496bb790494d6f6061b0
Autor:
Kevin Boyé, Luiz Henrique Geraldo, Jessica Furtado, Laurence Pibouin-Fragner, Mathilde Poulet, Doyeun Kim, Bryce Nelson, Yunling Xu, Laurent Jacob, Nawal Maissa, Dritan Agalliu, Lena Claesson-Welsh, Susan L. Ackerman, Anne Eichmann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors show that Netrin-1-Unc5B signaling controls blood-brain barrier integrity by maintaining Wnt/b-catenin signaling and that delivery of antibodies blocking Netrin-1 binding to Unc5B causes transient and size-selective BBB breakdown.
Externí odkaz:
https://doaj.org/article/7945797555614051a865fa97526dfd6d
Autor:
Mark Richards, Emmanuel Nwadozi, Sagnik Pal, Pernilla Martinsson, Mika Kaakinen, Marleen Gloger, Elin Sjöberg, Katarzyna Koltowska, Christer Betsholtz, Lauri Eklund, Sofia Nordling, Lena Claesson-Welsh
Publikováno v:
eLife, Vol 11 (2022)
Dysfunctional and leaky blood vessels resulting from disruption of the endothelial cell (EC) barrier accompanies numerous diseases. The EC barrier is established through endothelial cell tight and adherens junctions. However, the expression pattern a
Externí odkaz:
https://doaj.org/article/aee5113c0a174d1eb4e3dc510f9f251e
Autor:
Tor Persson Skare, Elin Sjöberg, Mattias Berglund, Ross O Smith, Francis P Roche, Cecilia Lindskog, Birgitta Sander, Ingrid Glimelius, Alex R Gholiha, Gunilla Enblad, Rose‐Marie Amini, Lena Claesson‐Welsh
Publikováno v:
eJHaem, Vol 1, Iss 1, Pp 199-207 (2020)
Abstract Purpose The abundant hepatocyte‐expressed plasma protein histidine‐rich glycoprotein (HRG) enhances antitumor immunity by polarizing inflammatory and immune cells in several mouse models, however, the clinical relevance of HRG in human c
Externí odkaz:
https://doaj.org/article/26002f47532a44658d296441c9fbab37
Autor:
Lena Claesson-Welsh
Publikováno v:
Upsala Journal of Medical Sciences, Vol 125, Iss 3, Pp 205-210 (2020)
Oxygen is of fundamental importance for most living organisms, and the maintenance of oxygen homeostasis is a key physiological challenge for all large animals. Oxygen deprivation, hypoxia, is a critical component of many human diseases including can
Externí odkaz:
https://doaj.org/article/ffe096fc6f914ebf9f2f49fce4ef71fa
Publikováno v:
Cells, Vol 11, Iss 17, p 2684 (2022)
The plasma protein histidine-rich glycoprotein (HRG) is implicated in the polarization of macrophages to an M1 antitumoral phenotype. The broadly expressed secreted protein stanniocalcin 2 (STC2), also implicated in tumor inflammation, is an HRG inte
Externí odkaz:
https://doaj.org/article/d7bb54c1e3ea4549a01a286f50e7d9b0
Autor:
Takeshi Ninchoji, Dominic T Love, Ross O Smith, Marie Hedlund, Dietmar Vestweber, William C Sessa, Lena Claesson-Welsh
Publikováno v:
eLife, Vol 10 (2021)
Background: Hypoxia and consequent production of vascular endothelial growth factor A (VEGFA) promote blood vessel leakiness and edema in ocular diseases. Anti-VEGFA therapeutics may aggravate hypoxia; therefore, therapy development is needed. Method
Externí odkaz:
https://doaj.org/article/22d057117123401086a68b774154e78c
Autor:
Anne-Clémence Vion, Tijana Perovic, Charlie Petit, Irene Hollfinger, Eireen Bartels-Klein, Emmanuelle Frampton, Emma Gordon, Lena Claesson-Welsh, Holger Gerhardt
Publikováno v:
Frontiers in Physiology, Vol 11 (2021)
Vascular networks form, remodel and mature under the influence of multiple signals of mechanical or chemical nature. How endothelial cells read and interpret these signals, and how they integrate information when they are exposed to both simultaneous
Externí odkaz:
https://doaj.org/article/4a8d984c48814e5a99b58d78fa150ab5
Autor:
Xiujuan Li, Björn Redfors, Miguel Sáinz-Jaspeado, Shujing Shi, Pernilla Martinsson, Narendra Padhan, Margareta Scharin Täng, Jan Borén, Malin Levin, Lena Claesson-Welsh
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
AimThe acute phase of myocardial infarction (MI) is accompanied by edema contributing to tissue damage and disease outcome. Here, we aimed to identify the mechanism whereby vascular endothelial growth factor (VEGF)-A induces myocardial edema in the a
Externí odkaz:
https://doaj.org/article/86ee85b548794f66853e0d403d60833f
Autor:
Ross O Smith, Takeshi Ninchoji, Emma Gordon, Helder André, Elisabetta Dejana, Dietmar Vestweber, Anders Kvanta, Lena Claesson-Welsh
Publikováno v:
eLife, Vol 9 (2020)
Edema stemming from leaky blood vessels is common in eye diseases such as age-related macular degeneration and diabetic retinopathy. Whereas therapies targeting vascular endothelial growth factor A (VEGFA) can suppress leakage, side-effects include v
Externí odkaz:
https://doaj.org/article/9e7f759c6eb54ac3af3a03679e04ff12