Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Lena Christin Conradi"'
Autor:
Arun Everest‐Dass, Stepan Nersisyan, Hanna Maar, Victor Novosad, Jennifer Schröder‐Schwarz, Vera Freytag, Johanna L. Stuke, Mia C. Beine, Alina Schiecke, Marie‐Therese Haider, Malte Kriegs, Omar Elakad, Hanibal Bohnenberger, Lena‐Christin Conradi, Maria Raygorodskaya, Linda Krause, Mark vonItzstein, Alexander Tonevitsky, Udo Schumacher, Diana Maltseva, Daniel Wicklein, Tobias Lange
Publikováno v:
Molecular Oncology, Vol 18, Iss 1, Pp 62-90 (2024)
Hematogenous metastasis limits the survival of colorectal cancer (CRC) patients. Here, we illuminated the roles of CD44 isoforms in this process. Isoforms 3 and 4 were predominantly expressed in CRC patients. CD44 isoform 4 indicated poor outcome and
Externí odkaz:
https://doaj.org/article/c19589a2bdca416b84704f2b8e082ac3
Autor:
Lena Wiedmann, Francesca De Angelis Rigotti, Nuria Vaquero-Siguero, Elisa Donato, Elisa Espinet, Iris Moll, Elisenda Alsina-Sanchis, Hanibal Bohnenberger, Elena Fernandez-Florido, Ronja Mülfarth, Margherita Vacca, Jennifer Gerwing, Lena-Christin Conradi, Philipp Ströbel, Andreas Trumpp, Carolin Mogler, Andreas Fischer, Juan Rodriguez-Vita
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Pancreatic ductal adenocarcinoma (PDAC) frequently metastasizes into the peritoneum, which contributes to poor prognosis. Metastatic spreading is promoted by cancer cell plasticity, yet its regulation by the microenvironment is incompletely
Externí odkaz:
https://doaj.org/article/2e93fce2b3b54b13883ba9d597b21173
Autor:
Johannes Robert Fleischer, Alexandra Maria Schmitt, Gwendolyn Haas, Xingbo Xu, Elisabeth Maria Zeisberg, Hanibal Bohnenberger, Stefan Küffer, Laure-Anne Teuwen, Philipp Johannes Karras, Tim Beißbarth, Annalen Bleckmann, Mélanie Planque, Sarah-Maria Fendt, Peter Vermeulen, Michael Ghadimi, Joanna Kalucka, Tiago De Oliveira, Lena-Christin Conradi
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-22 (2023)
Abstract Background Colorectal cancer liver metastases (CRCLM) are associated with a poor prognosis, reflected by a five-year survival rate of 14%. Anti-angiogenic therapy through anti-VEGF antibody administration is one of the limited therapies avai
Externí odkaz:
https://doaj.org/article/380114cc6bdc4ae19d7ea19ff089eb9c
Autor:
Leif Hendrik Dröge, Steffen Hennies, Stephan Lorenzen, Lena-Christin Conradi, Henriette Quack, Torsten Liersch, Christian Helms, Miriam Alice Frank, Markus Anton Schirmer, Margret Rave-Fränk, Tim Beißbarth, Hendrik Andreas Wolff
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background The question whether lymphocyte radiosensitivity is representative of patients’ response to radiotherapy (RT) remains unsolved. We analyzed lymphocyte cytogenetic damage in patients who were homogeneously treated with preoperati
Externí odkaz:
https://doaj.org/article/79126b28e2d24d44a34e52770d667c1a
Autor:
Luisa Klemke, Tiago De Oliveira, Daria Witt, Nadine Winkler, Hanibal Bohnenberger, Richard Bucala, Lena-Christin Conradi, Ramona Schulz-Heddergott
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-16 (2021)
Abstract Macrophage migration inhibitory factor (MIF) is an upstream regulator of innate immunity, but its expression is increased in some cancers via stabilization with HSP90-associated chaperones. Here, we show that MIF stabilization is tumor-speci
Externí odkaz:
https://doaj.org/article/5913f00e4bfb487c814a372f7b9eab49
Autor:
Laure-Anne Teuwen, Laura P.M.H. De Rooij, Anne Cuypers, Katerina Rohlenova, Sébastien J. Dumas, Melissa García-Caballero, Elda Meta, Jacob Amersfoort, Federico Taverna, Lisa M. Becker, Nuphar Veiga, Anna Rita Cantelmo, Vincent Geldhof, Nadine V. Conchinha, Joanna Kalucka, Lucas Treps, Lena-Christin Conradi, Shawez Khan, Tobias K. Karakach, Stefaan Soenen, Stefan Vinckier, Luc Schoonjans, Guy Eelen, Steven Van Laere, Mieke Dewerchin, Luc Dirix, Massimiliano Mazzone, Yonglun Luo, Peter Vermeulen, Peter Carmeliet
Publikováno v:
Cell Reports, Vol 35, Iss 11, Pp 109253- (2021)
Summary: Tumor vessel co-option is poorly understood, yet it is a resistance mechanism against anti-angiogenic therapy (AAT). The heterogeneity of co-opted endothelial cells (ECs) and pericytes, co-opting cancer and myeloid cells in tumors growing vi
Externí odkaz:
https://doaj.org/article/7dadc23d237d4576aa0fd412a6c1555b
Autor:
Lena-Christin Conradi, Melanie Spitzner, Anna-Lena Metzger, Merle Kisly, Peter Middel, Hanibal Bohnenberger, Jochen Gaedcke, Michael B. Ghadimi, Torsten Liersch, Joseph Rüschoff, Tim Beißbarth, Alexander König, Marian Grade
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)
Abstract Background Abrogation of growth factor-dependent signaling represents an effective therapeutic strategy for patients with colorectal cancer (CRC). Here we evaluated the effectiveness of targeting the epidermal growth factor (EGF) receptors H
Externí odkaz:
https://doaj.org/article/6b00a26effe1468b968df1dc6e299f26
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
In modern anti-cancer therapy of metastatic colorectal cancer (mCRC) the anti-angiogenic treatment targeting sprouting angiogenesis is firmly established for more than a decade. However, its clinical benefits still remain limited. As liver metastases
Externí odkaz:
https://doaj.org/article/f7e5165668d3498595641d89966667d0
Autor:
Johannes Robert Fleischer, Chiara Angelina Jodszuweit, Michael Ghadimi, Tiago De Oliveira, Lena-Christin Conradi
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Utilizing single-cell sequencing, recent studies were able to analyze at a greater resolution the heterogeneity of the vasculature and its complex composition in different tissues. Differing subpopulations have been detected, distinguishable only by
Externí odkaz:
https://doaj.org/article/f6a3a7f711e249ab916b69fa924e9d89
Autor:
Torsten Liersch, Claus Rödel, Heinz Becker, Müjdat Yildirim, B. Michael Ghadimi, Hendrik A. Wolff, Kia Homayounfar, Hilka Rothe, Lena-Christin Conradi, Tim Beissbarth, Franz Rödel, Thilo Sprenger
Supplementary Figure S1; Supplementary Table S1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ddef6681d6e15d33fc24d93ccfdd1d
https://doi.org/10.1158/1078-0432.22442858.v1
https://doi.org/10.1158/1078-0432.22442858.v1
