Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Lena C. Preiss"'
Autor:
Reza Zandi Shafagh, Sonia Youhanna, Jibbe Keulen, Joanne X. Shen, Nayere Taebnia, Lena C. Preiss, Kathrin Klein, Florian A. Büttner, Mikael Bergqvist, Wouter van derWijngaart, Volker M. Lauschke
Publikováno v:
Advanced Science, Vol 9, Iss 34, Pp n/a-n/a (2022)
Abstract Aberrant glucose homeostasis is the most common metabolic disturbance affecting one in ten adults worldwide. Prediabetic hyperglycemia due to dysfunctional interactions between different human tissues, including pancreas and liver, constitut
Externí odkaz:
https://doaj.org/article/657e83a29fa94ec4aab23e829d3d2254
Autor:
Ruoqi Liu, Katrin Georgi, David C. Thompson, Lena C. Preiss, Volker M. Lauschke, Carl Petersson, Lassina Badolo, Philip G. Hewitt
Publikováno v:
Drug Metabolism and Disposition. 49:668-678
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and PXR/CAR knockout (KO) HepaRG cells, as well as a PXR reporter gene assay, were used to investigate the mechanism of CYP3A4 and CYP2B6 induction by prototypical substrates and a gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6730fb35b0587e13b055fd63d2faca6
https://doi.org/10.1124/dmd.120.000333
https://doi.org/10.1124/dmd.120.000333
Publikováno v:
The AAPS journal. 24(2)
Accurate prediction of human pharmacokinetics using in vitro tools is an important task during drug development. Albeit, currently used in vitro systems for clearance extrapolation such as microsomes and primary human hepatocytes in suspension cultur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bdc990e5250a292ba0c94be5b54f758
https://pubmed.ncbi.nlm.nih.gov/35277751
https://pubmed.ncbi.nlm.nih.gov/35277751