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pro vyhledávání: '"Lena Brydon"'
Autor:
Lena Brydon
Publikováno v:
Biological Psychology
Evidence suggests that individuals who are more obese may be more responsive to stress. Stress activates the sympathetic nervous system (SNS) and the adipose-tissue cytokine leptin stimulates SNS activity in animals. We examined the relationship betw
Publikováno v:
Psychological Medicine. 40:2079-2087
BackgroundAlthough a substantial body of research points to a link between psychological distress and inflammatory responses in middle-aged and older adults, particularly those with cardiovascular disease, the relationship between inflammation and di
Autor:
Mimi R. Bhattacharyya, Daisy L. Whitehead, Ian Zachary, Philip C. Strike, Lena Brydon, Jean R. McEwan, Andrew Steptoe
Publikováno v:
Journal of Psychosomatic Research
Objective: Evidence suggests that emotional stress can trigger acute coronary syndromes in patients with advanced coronary artery disease (CAD), although the mechanisms involved remain unclear. Hostility is associated with heightened reactivity to st
Autor:
Hugo D. Critchley, Neil A. Harrison, Andrew Steptoe, Marcus A. Gray, Cicely Walker, Lena Brydon
Publikováno v:
Biological Psychiatry
Background Inflammatory cytokines are implicated in the pathophysiology of depression. In rodents, systemically administered inflammatory cytokines induce depression-like behavior. Similarly in humans, therapeutic interferon-α induces clinical depre
Autor:
Andrew J. Wawrzyniak, Akira Tsuda, Daisy L. Whitehead, Andrew Steptoe, Lena Brydon, Hisayoshi Okamura, Jumpei Yajima, Cicely Walker
Publikováno v:
Brain, Behavior, and Immunity
Activation of the innate immune system is commonly accompanied by a set of behavioural, psychological and physiological changes known as ‘sickness behaviour’. In animals, infection-related sickness symptoms are significantly increased by exposure
Autor:
Andrew Steptoe, Lena Brydon
Publikováno v:
Neuroscience & Biobehavioral Reviews. 33:63-70
Psychological factors may contribute not only to the evolution of coronary atherosclerosis and long-term risk of coronary heart disease, but also to the triggering of acute cardiac events in patients with advanced atherosclerosis. Evidence for emotio
Publikováno v:
Brain, Behavior, and Immunity
Evidence suggests that optimism may be protective for health during times of heightened stress, yet the mechanisms involved remain unclear. In a double-blind placebo-controlled study, we recently showed that acute psychological stress and an immune s
Autor:
Jane Wardle, Lena Brydon, Katie O'Donnell, Andrew J. Wawrzyniak, Andrew Steptoe, Caroline E. Wright
Publikováno v:
Obesity. 16:2642-2647
Obesity is associated with an elevated risk of hypertension and cardiovascular disease. The adipocyte hormone leptin, which stimulates energy expenditure in animals by activating the sympathetic nervous system (SNS), is believed to play a role in thi
Autor:
Lena Brydon, Ann E. Donald, John E. Deanfield, Bryony Field, Elizabeth A Ellins, Andrew Steptoe, Julian Halcox
Publikováno v:
Brain, Behavior, and Immunity. 22:941-948
The processes through which psychological stress influences cardiovascular disease are poorly understood, but may involve activation of hemodynamic, neuroendocrine and inflammatory responses. We assessed the relationship between carotid arterial stif
Publikováno v:
International Journal of Obesity. 32:443-450
Evidence suggests that people who are more responsive to psychological stress are at an increased risk of developing obesity. However, the biological mechanisms underlying this phenomenon are poorly understood. The cytokines leptin, interleukin-1 rec