HES6 knockdown in human hematopoietic precursor cells reduces their in vivo engraftment potential and their capacity to differentiate into erythroid cells, B cells, T cells and plasmacytoid dendritic cells

Autor: Tamara De Vos, Nicole Oatman, Lena Boehme, Tom Putteman, Imke Velghe, Yana Van Droogenbroeck, Stijn De Munter, Michaela Cesnekova, Filip Van Nieuwerburgh, Bart Vandekerckhove, Jan Philippe, Tom Taghon

Publikováno v: Haematologica, Vol 999, Iss 1 (2024)

Hematopoiesis is driven by molecular mechanisms that induce differentiation and proliferation of hematopoietic stem cells and their progeny. This involves the activity of various transcription factors, such as members of the Hairy/Enhancer of Split (

Externí odkaz: https://doaj.org/article/2ba793734fde41f4aa47b970e723784c

Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function

Autor: Brooke C. Wilson, Lena Boehme, Ambra Annibali, Alan Hodgkinson, Thomas S. Carroll, Rebecca J. Oakey, Vlad C. Seitan

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)

ZBTB11 mutations have been identified in patients with intellectual disability and morphological brain and neuromuscular defects, although the etiology was unknown. Here, the authors demonstrate that ZBTB11 regulates mitochondrial function by facilit

Externí odkaz: https://doaj.org/article/adf8d876f768497c8f62fbbc52bfdbe3

Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF

Autor: Kai Ling Liang, Juliette Roels, Marieke Lavaert, Tom Putteman, Lena Boehme, Laurentijn Tilleman, Imke Velghe, Valentina Pegoretti, Inge Van de Walle, Stephanie Sontag, Jolien Vandewalle, Bart Vandekerckhove, Georges Leclercq, Pieter Van Vlierberghe, Claude Libert, Filip Van Nieuwerburgh, Roman Fischer, Roland E. Kontermann, Klaus Pfizenmaier, Gina Doody, Martin Zenke, Tom Taghon

Publikováno v: Nature Immunology. 24:474-486

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fe8dd9eba6e89dff5ac443d4375330b
https://doi.org/10.1038/s41590-022-01417-6

A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma

Autor: Eva Crosas-Molist, Lena Boehme, Faraz K. Mardakheh, Bruce Fanshawe, Jose L. Orgaz, Gilbert O. Fruhwirth, Irene Rodriguez-Hernandez, Victoria Sanz-Moreno, Oscar Maiques, Gaia Cantelli, Alessia Volpe

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
British Journal of Cancer
BRITISH JOURNAL OF CANCER

© The Author(s) 2021.
[Background]: Metastasis is a hallmark of cancer and responsible for most cancer deaths. Migrastatics were defined as drugs interfering with all modes of cancer cell invasion and thus cancers’ ability to metastasise. Fir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0245a51b1650d282bfda2f05b9dbaede
http://hdl.handle.net/10261/264785

Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function

Autor: Alan Hodgkinson, Lena Boehme, Brooke C. Wilson, Rebecca J. Oakey, Vlad C. Seitan, Thomas L. Carroll, Ambra Annibali

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications
Wilson, B, Boehme, L, Annibali, A, Hodgkinson, A, Carroll, T, Oakey, R & Seitan, V 2020, ' Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function ', Nature Communications, vol. 11, no. 1, 5469 . https://doi.org/10.1038/s41467-020-19205-x

Zbtb11 is a conserved transcription factor mutated in families with hereditary intellectual disability. Its precise molecular and cellular functions are currently unknown, precluding our understanding of the aetiology of this disease. Using a combina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7045c9d61202af8eba76171bfd75f160