Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Lena Blümel"'
Autor:
Lena Blümel, Nan Qin, Johannes Berlandi, Eunice Paisana, Rita Cascão, Carlos Custódia, David Pauck, Daniel Picard, Maike Langini, Kai Stühler, Frauke-Dorothee Meyer, Sarah Göbbels, Bastian Malzkorn, Max C. Liebau, João T. Barata, Astrid Jeibmann, Kornelius Kerl, Serap Erkek, Marcel Kool, Stefan M. Pfister, Pascal D. Johann, Michael C. Frühwald, Arndt Borkhardt, Guido Reifenberger, Claudia C. Faria, Ute Fischer, Martin Hasselblatt, Jasmin Bartl, Marc Remke
Publikováno v:
Cell Death and Disease, Vol 13, Iss 9, Pp 1-13 (2022)
Abstract Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant brain tumor in infants that is characterized by loss of nuclear expression of SMARCB1 or SMARCA4 proteins. Recent studies show that AT/RTs comprise three molecular subgroups, nam
Externí odkaz:
https://doaj.org/article/135ad632b2b8459392b5b46750bd8481
Autor:
Rebecca Hasselmann, Lena Blümel, Flavia Bernardi, Daniel Picard, Jacob Torrejon-Diaz, Vera Jepsen, Jasmin Bartl, Nan Qin, Beat Bornhauser, Sanil Bhatia, Blerim Marovca, Veronique Marsaud, Florent Dingli, Damarys Loew, Martin Stanulla, Jean-Pierre Bourquin, Arndt Borkhardt, Marc Remke, Olivier Ayrault, Ute Fischer
Publikováno v:
HemaSphere, Vol 7, p e580878c (2023)
Externí odkaz:
https://doaj.org/article/435c714ac72b465f9927a28a460799fa
Autor:
Jasmin Bartl, Marco Zanini, Flavia Bernardi, Antoine Forget, Lena Blümel, Julie Talbot, Daniel Picard, Nan Qin, Gabriele Cancila, Qingsong Gao, Soumav Nath, Idriss Mahoungou Koumba, Marietta Wolter, François Kuonen, Maike Langini, Thomas Beez, Christopher Munoz, David Pauck, Viktoria Marquardt, Hua Yu, Judith Souphron, Mascha Korsch, Christina Mölders, Daniel Berger, Sarah Göbbels, Frauke-Dorothee Meyer, Björn Scheffler, Barak Rotblat, Sven Diederichs, Vijay Ramaswamy, Hiromishi Suzuki, Anthony Oro, Kai Stühler, Anja Stefanski, Ute Fischer, Gabriel Leprivier, Dieter Willbold, Gerhard Steger, Alexander Buell, Marcel Kool, Peter Lichter, Stefan M. Pfister, Paul A. Northcott, Michael D. Taylor, Arndt Borkhardt, Guido Reifenberger, Olivier Ayrault, Marc Remke
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Long non-coding RNAs (lncRNAs) can contribute to cancers that are driven by Sonic hedgehog (SHH) signaling. Here the authors report that lncRNA HHIP-AS1 stabilises the mRNA of dynein complex 1, thereby, promoting the pro-mitotic effects of SHH-driven
Externí odkaz:
https://doaj.org/article/73686bb8743949ee8fd430a7515a3767
Autor:
Arndt Borkhardt, Nan Qin, Stephen T Keir, Darell D Bigner, Allison Cole, Matthias Wölfl, Viktoria Marquardt, Johanna Theruvath, David Pauck, Daniel Picard, Lena Blümel, Mara Maue, Jasmin Bartl, Ulvi Ahmadov, Maike Langini, Frauke-Dorothee Meyer, Joselyn Cruz-Cruz, Claus M Graef, Till Milde, Olaf Witt, Anat Erdreich-Epstein, Gabriel Leprivier, Ulf Kahlert, Anja Stefanski, Kai Stühler, Julia Hauer, Thomas Beez, Christiane B Knobbe-Thomsen, Ute Fischer, Jörg Felsberg, Finn K Hansen, Rajeev Vibhakar, Sujatha Venkatraman, Samuel H Cheshier, Guido Reifenberger, Thomas Kurz, Marc Remke, Siddhartha Mitra
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 1 (2023)
Background While major advances have been made in improving the quality of life and survival of children with most forms of medulloblastoma (MB), those with MYC-driven tumors (Grp3-MB) still suffer significant morbidity and mortality. There is an urg
Externí odkaz:
https://doaj.org/article/bea518d410cc4fd58c33516272b055a1
Autor:
Ulvi Ahmadov, Daniel Picard, Jasmin Bartl, Manuela Silginer, Marija Trajkovic-Arsic, Nan Qin, Lena Blümel, Marietta Wolter, Jonathan K. M. Lim, David Pauck, Alina Marie Winkelkotte, Marlen Melcher, Maike Langini, Viktoria Marquardt, Felix Sander, Anja Stefanski, Sascha Steltgens, Christina Hassiepen, Anna Kaufhold, Frauke-Dorothee Meyer, Annette Seibt, Lara Kleinesudeik, Anika Hain, Carsten Münk, Christiane Brigitte Knobbe-Thomsen, Alexander Schramm, Ute Fischer, Gabriel Leprivier, Kai Stühler, Simone Fulda, Jens T. Siveke, Felix Distelmaier, Arndt Borkhardt, Michael Weller, Patrick Roth, Guido Reifenberger, Marc Remke
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-11 (2021)
Abstract Glioblastoma is the most common malignant primary brain tumor. To date, clinically relevant biomarkers are restricted to isocitrate dehydrogenase (IDH) gene 1 or 2 mutations and O6-methylguanine DNA methyltransferase (MGMT) promoter methylat
Externí odkaz:
https://doaj.org/article/7af56daa21a545719f08c431620aa3e9
Autor:
Nan Qin, Eunice Paisana, Maike Langini, Daniel Picard, Bastian Malzkorn, Carlos Custódia, Rita Cascão, Frauke-Dorothee Meyer, Lena Blümel, Sarah Göbbels, Kübra Taban, Jasmin Bartl, Nicole Bechmann, Catleen Conrad, Jan Gravemeyer, Jürgen C Becker, Anja Stefanski, Stéphanie Puget, João T Barata, Kai Stühler, Ute Fischer, Jörg Felsberg, Olivier Ayrault, Guido Reifenberger, Arndt Borkhardt, Graeme Eisenhofer, Claudia C Faria, Marc Remke
Publikováno v:
Neuro Oncol
Background Intratumoral heterogeneity is crucially involved in metastasis, resistance to therapy, and cancer relapse. Amplifications of the proto-oncogene MYC display notable heterogeneity at the single-cell level and are associated with a particular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a687c7b56bf82c7501730aea4161819d
https://pubmed.ncbi.nlm.nih.gov/35307743
https://pubmed.ncbi.nlm.nih.gov/35307743
Autor:
Viktoria Marquardt, Johanna Theruvath, David Pauck, Daniel Picard, Nan Qin, Lena Blümel, Mara Maue, Jasmin Bartl, Ulvi Ahmadov, Maike Langini, Frauke-Dorothee Meyer, Allison Cole, Joselyn Cruz-Cruz, Claus M Graef, Matthias Wölfl, Till Milde, Olaf Witt, Anat Erdreich-Epstein, Gabriel Leprivier, Ulf Kahlert, Anja Stefanski, Kai Stühler, Stephen T Keir, Darell D Bigner, Julia Hauer, Thomas Beez, Christiane B Knobbe-Thomsen, Ute Fischer, Jörg Felsberg, Finn K Hansen, Rajeev Vibhakar, Sujatha Venkatraman, Samuel H Cheshier, Guido Reifenberger, Arndt Borkhardt, Thomas Kurz, Marc Remke, Siddhartha Mitra
Publikováno v:
Journal for ImmunoTherapy of Cancer. 11:e005871
BackgroundWhile major advances have been made in improving the quality of life and survival of children with most forms of medulloblastoma (MB), those with MYC-driven tumors (Grp3-MB) still suffer significant morbidity and mortality. There is an urge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5471b55cfef831599420b52600f226d0
https://doi.org/10.1136/jitc-2022-005871
https://doi.org/10.1136/jitc-2022-005871
Autor:
Lena Blümel, Marc Remke, Frauke-Dorothee Meyer, Sarah Göbbels, Nan Qin, Guido Reifenberger, Ute Fischer, Daniel Picard, Jasmin Bartl, Daniel Rickert, Arndt Borkhardt, David Pauck
Publikováno v:
Neuro-Oncology
Introduction Resistance to chemotherapy is a common cause of treatment failure in cancer patients and a major problem facing current cancer research. Targeted modulation of oncogenic signaling pathways may be used to systematically characterize drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a391b5ee2c31af319b98372cdcb96f59
http://europepmc.org/articles/PMC8168144
http://europepmc.org/articles/PMC8168144
Autor:
Arndt Borkhardt, Nan Qin, Finn K. Hansen, Johanna Theruvath, Samuel H. Cheshier, Guido Reifenberger, Jörg Felsberg, Lena Blümel, Siddhartha Mitra, David Pauck, Viktoria Marquardt, Marc Remke, Daniel Picard, Thomas Kurz
Medulloblastoma is the most common malignant brain tumor in childhood and comprises four distinct molecular subgroups with further layers of intertumoral heterogeneity. Amplification of the oncogene MYC drives tumorigenesis and constitutes a hallmark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953f73143d668670f9d152671fc88841
https://europepmc.org/articles/PMC6477330/
https://europepmc.org/articles/PMC6477330/
Autor:
Arndt Borkhardt, Thomas Beez, Viktoria Marquardt, Hans Jakob Steiger, Mara Maue, Eunice Paisana, Christian Dimitriadis, Kübra Taban, Lena Blümel, Ute Fischer, Claudia C. Faria, Rita Cascão, Guido Reifenberger, Daniel Picard, Marc Remke, Jasmin Bartl, Sevgi Sarikaya-Seiwert, David Pauck
Publikováno v:
Neuro-Oncology
Subgroups of ependymoma, especially RELA fusion-positive and posterior fossa type A tumors, are associated with poor prognosis. Curative therapeutic strategies have not yet been identified. We set up a high-throughput drug screening (HTS) pipeline to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fbc3f0fb0893f288dc991a0098bd8f2
http://europepmc.org/articles/PMC7715461
http://europepmc.org/articles/PMC7715461