Intestinal protection by proanthocyanidins involves anti-oxidative and anti-inflammatory actions in association with an improvement of insulin sensitivity, lipid and glucose homeostasis

Autor: Mireille Koudoufio, Francis Feldman, Lena Ahmarani, Edgard Delvin, Schohraya Spahis, Yves Desjardins, Emile Levy

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Recent advances have added another dimension to the complexity of cardiometabolic disorders (CMD) by directly implicating the gastrointestinal tract as a key player. In fact, multiple factors could interfere with intestinal homeostasis and e

Externí odkaz: https://doaj.org/article/9b3f93f7fc3143148477bbad6ab910a1

SAR1B GTPase is necessary to protect intestinal cells from disorders of lipid homeostasis, oxidative stress, and inflammation[S]

Autor: Alain Sané, Lena Ahmarani, Edgard Delvin, Nikolas Auclair, Schohraya Spahis, Emile Levy

Publikováno v: Journal of Lipid Research, Vol 60, Iss 10, Pp 1755-1764 (2019)

Genetic defects in SAR1B GTPase inhibit chylomicron (CM) trafficking to the Golgi and result in a huge intraenterocyte lipid accumulation with a failure to release CMs and liposoluble vitamins into the blood circulation. The central aim of this study

Externí odkaz: https://doaj.org/article/73dbe0ba6ac042839aad082b853f5906

Glycomacropeptide for Management of Insulin Resistance and Liver Metabolic Perturbations

Autor: Mathilde Foisy Sauvé, Francis Feldman, Mireille Koudoufio, Nour-El-Houda Ould-Chikh, Lena Ahmarani, Alain Sane, Thierry N’Timbane, Ramy El-Jalbout, Nathalie Patey, Schohraya Spahis, Alain Stintzi, Edgard Delvin, Emile Levy

Publikováno v: Biomedicines, Vol 9, Iss 9, p 1140 (2021)

Background and Aims: The increasing prevalence and absence of effective global treatment for metabolic syndrome (MetS) are alarming given the potential progression to severe non-communicable disorders such as type 2 diabetes and nonalcoholic fatty li

Externí odkaz: https://doaj.org/article/8f78a14e274f45a8970a1de805096e14

Sar1b mutant mice recapitulate gastrointestinal abnormalities associated with chylomicron retention disease

Autor: Emile Levy, Nickolas Auclair, Lena Ahmarani, Jean-François Beaulieu, Noël Peretti, Nathalie Patey, Schohraya Spahis, Alain T. Sané

Publikováno v: Journal of Lipid Research
Journal of Lipid Research, 2021, 62, pp.100085. ⟨10.1016/j.jlr.2021.100085⟩
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2021, 62, pp.100085. ⟨10.1016/j.jlr.2021.100085⟩
Journal of Lipid Research, Vol 62, Iss, Pp 100085-(2021)

International audience; Chylomicron retention disease (CRD) is an autosomal recessive disorder associated with biallelic Sar1b mutations leading to defects in intracellular chylomicron (CM) trafficking and secretion. To date, a direct cause-effect re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437c6d76490d2b00b616f9ab5275cf52
https://doi.org/10.1016/j.jlr.2021.100085

Glycomacropeptide Prevents Iron/Ascorbate-Induced Oxidative Stress, Inflammation and Insulin Sensitivity with an Impact on Lipoprotein Production in Intestinal Caco-2/15 Cells

Autor: Edgard Delvin, Schohraya Spahis, Alain T. Sané, Mathilde Foisy-Sauvé, Lena Ahmarani, Emile Levy

Publikováno v: Nutrients, Vol 12, Iss 1175, p 1175 (2020)
Nutrients
Volume 12
Issue 4

Background. Metabolic Syndrome (MetS), a major worldwide concern for the public health system, refers to a cluster of key metabolic components, and represents a risk factor for diabetes and cardiovascular diseases. As oxidative stress (OxS) and infla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebff2f249fbb819c25278d76a073452
https://www.mdpi.com/2072-6643/12/4/1175