A direct projection from mouse primary visual cortex to dorsomedial striatum.

Autor: Lena A Khibnik, Nicolas X Tritsch, Bernardo L Sabatini

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e104501 (2014)

The mammalian striatum receives inputs from many cortical areas, but the existence of a direct axonal projection from the primary visual cortex (V1) is controversial. In this study we use anterograde and retrograde tracing techniques to demonstrate t

Externí odkaz: https://doaj.org/article/316736570f874e2587b87a61f6972b68

Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress

Autor: Georgia E. Hodes, Sam A. Golden, Aditi Dey, Milo R. Smith, Jessica L. Ables, Hossein Aleyasin, Lena A. Khibnik, Nicole Rebusi, Kevin G. Guise, Gabriel A. Ben-Dor, Daniel J. Christoffel, Jessica J. Walsh, Mitra Heshmati, Madeline L. Pfau, Allyson K. Friedman, Robert C. Malenka, Matthew L. Shapiro, Inés Ibañez-Tallon, Karl Deisseroth, Ming-Hu Han, Scott J. Russo

Publikováno v: Nature neuroscience

Postsynaptic remodeling of glutamatergic synapses on ventral striatum (vSTR) medium spiny neurons (MSNs) is critical for shaping stress responses. However, it is unclear which presynaptic inputs are involved. Susceptible mice exhibited increased syna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804af969368b4a6200dffe0ddad1398c
https://doi.org/10.1038/nn.4034

The ratio of NR2A/B NMDA receptor subunits determines the qualities of ocular dominance plasticity in visual cortex

Autor: Mark F. Bear, Kathleen K. A. Cho, Lena A. Khibnik, Benjamin D. Philpot

Publikováno v: Proceedings of the National Academy of Sciences. 106:5377-5382

Bidirectional synaptic plasticity during development ensures that appropriate synapses in the brain are strengthened and maintained while inappropriate connections are weakened and eliminated. This plasticity is well illustrated in mouse visual corte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111a92c18b0b8e6d379856e49a9c8dfe
https://doi.org/10.1073/pnas.0808104106

Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity

Autor: Sam F. Cooke, Lena A. Khibnik, Alexander A. Chubykin, Jeffrey P. Gavornik, Robert W. Komorowski, Aurore Thomazeau, Eitan S. Kaplan, Mark F. Bear

Publikováno v: eLife Sciences Publications, Ltd.
Kaplan, E S, Cooke, S, Komorowski, R W, Chubykin, A A, Thomazeau, A, Khibnik, L A, Gavornik, J P & Bear, M F 2016, ' Contrasting Roles for Parvalbumin-Expressing Inhibitory Neurons in Two Forms of Adult Visual Cortical Plasticity ', eLife, vol. 5, no. 1, 11450, pp. 1-27 . https://doi.org/10.7554/eLife.11450
eLife
eLife, Vol 5 (2016)

The roles played by cortical inhibitory neurons in experience-dependent plasticity are not well understood. Here we evaluate the participation of parvalbumin-expressing (PV+) GABAergic neurons in two forms of experience-dependent modification of prim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a6462c2010e29ec5ef5884d2dc328e
http://hdl.handle.net/1721.1/102620

Relative contribution of feed-forward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex

Autor: Mark F. Bear, Kathleen K. A. Cho, Lena A. Khibnik

Publikováno v: PubMed Central

Brief monocular deprivation (MD) shifts ocular dominance (OD) in primary visual cortex by causing depression of responses to the deprived eye. Here we address the extent to which the shift is expressed by a modification of excitatory synaptic transmi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ead4be850fe6b175b431e1aac22728c
https://europepmc.org/articles/PMC2917336/