Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Lena A Grosser"'
Autor:
Michael B. Gravestock, Amanda Doucette, Lena A Grosser, Sheila Irene Hauck, C. Cederberg, Neil James Hales, Grace Poon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:337-340
Substitution of phenyl oxazolidinones with carbon-linked azoles resulted in the discovery of a new class of potent oxazolidinones that have excellent Gram-positive activity. In addition, replacement of the C-5 acetamide side chains with a 4-methyl tr
Autor:
Virna J A Schuck, Grant K. Walkup, Stewart L. Fisher, Ed T. Buurman, David E. Ehmann, Michele Johnstone, Fereidoon Daryaee, Laurel Hajec, Michael R. Hale, Allison Laura Choy, Sara A. Patey, Zhiping You, Kerry E. Murphy-Benenato, Valerie Marone, Lena A Grosser, Philip L. Ross, Stephen G. Walker, John O'Donnell, Eleanor K. H. Allen, Peter J. Tonge
Many drug candidates fail in clinical trials owing to a lack of efficacy from limited target engagement or an insufficient therapeutic index. Minimizing off-target effects while retaining the desired pharmacodynamic (PD) response can be achieved by r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20caa4d0aff3f316fda11431229c47d
https://europepmc.org/articles/PMC4536915/
https://europepmc.org/articles/PMC4536915/