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Hydrophobicity engineering of cholera toxin A1 subunit in the strong adjuvant fusion protein CTA1-DD
Publikováno v:
Protein Engineering, Design and Selection. 12:173-178
Protein engineering of the cholera toxin A1 subunit (CTA1) fused to a dimer of the Ig-binding D-region of Staphylococcus aureus protein A (DD) was employed to investigate the effect of specific amino acid changes on solubility, stability, enzymatic a
Publikováno v:
Immunology and Cell Biology. 76:280-287
A promising novel concept in mucosal adjuvant research is demonstrated here. The adjuvant and toxic effects of the cholera toxin (CT) have been successfully separated in a gene fusion protein, CTA1-DD. This protein consists of the ADP-ribosylating A1
Autor:
Tomáš Hanke, Christina Barnfield, Edmund G.-T. Wee, Rachel V. Samuel, Peter Liljeström, Lena Ågren, Natasha Larke
Publikováno v:
The Journal of general virology. 84(Pt 2)
A novel, experimental subunit human immunodeficiency virus (HIV) vaccine, SFV.HIVA, was constructed. This consists of Semliki Forest virus (SFV), which is a suitable vaccine vector for use in humans, and a passenger gene encoding HIVA, which is an im