Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Lena, Kjellén"'
Autor:
Judith Habicher, Gaurav K Varshney, Laura Waldmann, Daniel Snitting, Amin Allalou, Hanqing Zhang, Abdurrahman Ghanem, Caroline Öhman Mägi, Tabea Dierker, Lena Kjellén, Shawn M Burgess, Johan Ledin
Publikováno v:
PLoS Genetics, Vol 18, Iss 2, p e1010067 (2022)
Chondroitin/dermatan sulfate (CS/DS) proteoglycans are indispensable for animal development and homeostasis but the large number of enzymes involved in their biosynthesis have made CS/DS function a challenging problem to study genetically. In our stu
Externí odkaz:
https://doaj.org/article/14829a228b8e40ef9f46f01aa8efbb7b
Autor:
Mattias Belting, Maria C. Johansson, Johan Bengzon, Charlotte Welinder, Lena Kjellén, Vineesh Indira Chandran, Eva Lindqvist, Katrin J. Svensson, Erika Bourseau-Guilmain, Paulina Kucharzewska, Helena C. Christianson, Julien A. Menard
Figure S3. A,B, Increased lipoprotein uptake by hypoxia in several cell types. C, Temperature-dependent uptake of lipoproteins. D, Competitive inhibition of DiI-labelled lipoprotein uptake. E and F, Hypoxia does not induce macropinocytosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2a964343b5ac525eeefcc888d96948
https://doi.org/10.1158/0008-5472.22403549
https://doi.org/10.1158/0008-5472.22403549
Autor:
Mattias Belting, Maria C. Johansson, Johan Bengzon, Charlotte Welinder, Lena Kjellén, Vineesh Indira Chandran, Eva Lindqvist, Katrin J. Svensson, Erika Bourseau-Guilmain, Paulina Kucharzewska, Helena C. Christianson, Julien A. Menard
Supplementary Materials & Methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59eaba54dc6bcdf0dbd3289570d94b83
https://doi.org/10.1158/0008-5472.22403537.v1
https://doi.org/10.1158/0008-5472.22403537.v1
Autor:
Mattias Belting, Maria C. Johansson, Johan Bengzon, Charlotte Welinder, Lena Kjellén, Vineesh Indira Chandran, Eva Lindqvist, Katrin J. Svensson, Erika Bourseau-Guilmain, Paulina Kucharzewska, Helena C. Christianson, Julien A. Menard
Table S1. Label free LC-MS/MS quantification of LRP1 shows no induction by hypoxia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d3c78fb46f2576e53e95ea98499fdd8
https://doi.org/10.1158/0008-5472.22403534
https://doi.org/10.1158/0008-5472.22403534
Autor:
Mattias Belting, Maria C. Johansson, Johan Bengzon, Charlotte Welinder, Lena Kjellén, Vineesh Indira Chandran, Eva Lindqvist, Katrin J. Svensson, Erika Bourseau-Guilmain, Paulina Kucharzewska, Helena C. Christianson, Julien A. Menard
Figure S6. Hypoxia induced ERK/MAPK signaling activation by lipoproteins. A, Cell signaling activation by lipoproteins. B and C, Prolonged lipoprotein-mediated ERK1/2 activation in hypoxia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6ac594cd49dc5d063ad5ddcc905385
https://doi.org/10.1158/0008-5472.22403540.v1
https://doi.org/10.1158/0008-5472.22403540.v1
Autor:
Mattias Belting, Maria C. Johansson, Johan Bengzon, Charlotte Welinder, Lena Kjellén, Vineesh Indira Chandran, Eva Lindqvist, Katrin J. Svensson, Erika Bourseau-Guilmain, Paulina Kucharzewska, Helena C. Christianson, Julien A. Menard
Figure S5. A-D, Hypoxic induction of lipoprotein receptor expression in GBM cells. E, Heparin treatment reverses hypoxic induction of lipoprotein uptake.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269bd3f344910d37419dbc501a8d7d0c
https://doi.org/10.1158/0008-5472.22403543
https://doi.org/10.1158/0008-5472.22403543
Autor:
Mattias Belting, Maria C. Johansson, Johan Bengzon, Charlotte Welinder, Lena Kjellén, Vineesh Indira Chandran, Eva Lindqvist, Katrin J. Svensson, Erika Bourseau-Guilmain, Paulina Kucharzewska, Helena C. Christianson, Julien A. Menard
Figure S1. Hypoxic induction of the expression of lipid metabolism related proteins and LDs is not related to acidosis, LDL aggregation or cell toxicity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06eed25976dbbd8d7b60b092554f5239
https://doi.org/10.1158/0008-5472.22403555
https://doi.org/10.1158/0008-5472.22403555
Autor:
Mattias Belting, Maria C. Johansson, Johan Bengzon, Charlotte Welinder, Lena Kjellén, Vineesh Indira Chandran, Eva Lindqvist, Katrin J. Svensson, Erika Bourseau-Guilmain, Paulina Kucharzewska, Helena C. Christianson, Julien A. Menard
Figure S2. LDL induces the accumulation of LD-associated cholesteryl esters in hypoxic cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236d37e9304df0abc96f2a82bc0105dd
https://doi.org/10.1158/0008-5472.22403552.v1
https://doi.org/10.1158/0008-5472.22403552.v1
Autor:
Mattias Belting, Maria C. Johansson, Johan Bengzon, Charlotte Welinder, Lena Kjellén, Vineesh Indira Chandran, Eva Lindqvist, Katrin J. Svensson, Erika Bourseau-Guilmain, Paulina Kucharzewska, Helena C. Christianson, Julien A. Menard
Figure S4. A, Efficient digestion of HS chains. B,C, Cell-surface lipoprotein binding in normoxia and hypoxia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b4c7e41c870e49fb00ef8b55e81b6c
https://doi.org/10.1158/0008-5472.22403546.v1
https://doi.org/10.1158/0008-5472.22403546.v1
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Mast cells (MCs) are characterized by an abundance of lysosome-like secretory granules filled with immunomodulatory compounds including histamine, cytokines, lysosomal hydrolases, MC-restricted proteases, and serglycin proteoglycans. The latter are e
Externí odkaz:
https://doaj.org/article/54985c78d2d24ff9b12530582d7c76c4