Zobrazeno 1 - 10
of 281
pro vyhledávání: '"Lena, Eliasson"'
Autor:
Styliani Panagiotou, Kia Wee Tan, Phuoc My Nguyen, Andreas Müller, Affiong Ika Oqua, Alejandra Tomas, Anna Wendt, Lena Eliasson, Anders Tengholm, Michele Solimena, Olof Idevall-Hagren
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113992- (2024)
Summary: Insulin is packaged into secretory granules that depart the Golgi and undergo a maturation process that involves changes in the protein and lipid composition of the granules. Here, we show that insulin secretory granules form physical contac
Externí odkaz:
https://doaj.org/article/ab020b44d66c4d84917ebea44d0e0a85
Autor:
Tina Rönn, Jones K. Ofori, Alexander Perfilyev, Alexander Hamilton, Karolina Pircs, Fabian Eichelmann, Sonia Garcia-Calzon, Alexandros Karagiannopoulos, Hans Stenlund, Anna Wendt, Petr Volkov, Matthias B. Schulze, Hindrik Mulder, Lena Eliasson, Sabrina Ruhrmann, Karl Bacos, Charlotte Ling
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Epigenetic dysregulation may influence disease progression. Here we explore whether epigenetic alterations in human pancreatic islets impact insulin secretion and type 2 diabetes (T2D). In islets, 5,584 DNA methylation sites exhibit alterati
Externí odkaz:
https://doaj.org/article/19bed20de77c4fe59cb47f79626a6477
Autor:
Kaisa Ryytty Sylvén, Ann-Louise Bergefur, Magdalena Jacobson, Per Wallgren, Lena Eliasson Selling
Publikováno v:
Acta Veterinaria Scandinavica, Vol 65, Iss 1, Pp 1-8 (2023)
Abstract Background Dermatophytosis (ringworm) caused by members of the Trichophyton mentagrophytes complex is rarely diagnosed in pigs but has been recognized as an increasingly common infection in humans. Further, resistance to antifungal drugs hav
Externí odkaz:
https://doaj.org/article/4b1475d5de9b464f8a822803df8b194e
Autor:
Claire L Lyons, Elaine Cowan, Oktawia Nilsson, Manca Mohar, Pablo Peña-Martínez, Lena Eliasson, Jens O Lagerstedt
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0311039 (2024)
Apolipoprotein A-I (ApoA-I), the primary component of high-density lipoprotein (HDL) cholesterol primes β-cells to increase insulin secretion, however, the mechanisms involved are not fully defined. Here, we aimed to confirm ApoA-I receptors in β-c
Externí odkaz:
https://doaj.org/article/afa99b8bdf8b4321a1e44d44ed27a9f7
Autor:
Andreas Lindqvist, Mia Abels, Liliya Shcherbina, Mtakai Ngara, Dmytro Kryvokhyzha, Sabrina Chriett, Matteo Riva, Abul Fajul, Mohammad Barghouth, Cheng Luan, Lena Eliasson, Olav Larsen, Mette M. Rosenkilde, Enming Zhang, Erik Renström, Nils Wierup
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108416- (2023)
Summary: Cocaine and amphetamine-regulated transcript (CART) is expressed in pancreatic islet cells and neuronal elements. We have previously established insulinotropic actions of CART in human and rodent islets. The receptor for CART in the pancreat
Externí odkaz:
https://doaj.org/article/5b28e5d6ce9a49798e8b5a806ad188f3
Autor:
Yingying Ye, Mohammad Barghouth, Haiqiang Dou, Cheng Luan, Yongzhi Wang, Alexandros Karagiannopoulos, Xiaoping Jiang, Ulrika Krus, Malin Fex, Quan Zhang, Lena Eliasson, Patrik Rorsman, Enming Zhang, Erik Renström
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Insulin secretion depends on action potential firing in pancreatic islet beta-cells, but the underlying mechanism is unclear. Here, the authors show that activation of the mechanosensor ion channel PIEZO1 plays a central role in beta-cell electrical
Externí odkaz:
https://doaj.org/article/15b342bbb06f4fbc8a098811ae253a0d
Autor:
Alexandros Karagiannopoulos, Efraim Westholm, Jones K. Ofori, Elaine Cowan, Jonathan L.S. Esguerra, Lena Eliasson
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106555- (2023)
Summary: Glucocorticoid use is associated with steroid-induced diabetes mellitus and impaired pancreatic β-cell insulin secretion. Here, the glucocorticoid-mediated transcriptomic changes in human pancreatic islets and the human insulin-secreting En
Externí odkaz:
https://doaj.org/article/68be0083631b4762bbc8a922b0b0f138
Autor:
Karl Bacos, Alexander Perfilyev, Alexandros Karagiannopoulos, Elaine Cowan, Jones K. Ofori, Ludivine Bertonnier-Brouty, Tina Rönn, Andreas Lindqvist, Cheng Luan, Sabrina Ruhrmann, Mtakai Ngara, Åsa Nilsson, Sevda Gheibi, Claire L. Lyons, Jens O. Lagerstedt, Mohammad Barghouth, Jonathan L.S. Esguerra, Petr Volkov, Malin Fex, Hindrik Mulder, Nils Wierup, Ulrika Krus, Isabella Artner, Lena Eliasson, Rashmi B. Prasad, Luis Rodrigo Cataldo, Charlotte Ling
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β cells. To identify candidate genes contributing to T2D pathophysiology, we studied human pancreatic islets from approximately 300 individuals. We found 395 different
Externí odkaz:
https://doaj.org/article/1b6d5184407e4059bd119a1db2f0c8ba
Autor:
Lena Eliasson
Publikováno v:
Revista de la Sociedad Argentina de Diabetes, Vol 55, Iss 3Sup, Pp 7-10 (2021)
Insulin released from β-cells within the pancreatic islet of Langerhans is central in the control of blood glucose homeostasis. A combination of environmental and genetic factors can lead to defects in this regulation and lead to type 2 diabetes (T2
Externí odkaz:
https://doaj.org/article/ac266fc5601f4142b7aaa9cccbae7fbd
Autor:
Luis Rodrigo Cataldo, Qian Gao, Lidia Argemi-Muntadas, Ondrej Hodek, Elaine Cowan, Sergey Hladkou, Sevda Gheibi, Peter Spégel, Rashmi B. Prasad, Lena Eliasson, Camilla Scheele, Malin Fex, Hindrik Mulder, Thomas Moritz
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101629- (2022)
Objective: Ependymin-Related Protein 1 (EPDR1) was recently identified as a secreted human batokine regulating mitochondrial respiration linked to thermogenesis in brown fat. Despite that EPDR1 is expressed in human pancreatic β-cells and that gluco
Externí odkaz:
https://doaj.org/article/020d789591674d79befd05b5d255d820