Lysophosphatidylinositol-acyltransferase-1 (LPIAT1) is required to maintain physiological levels of PtdIns and PtdInsP(2) in the mouse.

Autor: Karen E Anderson, Anna Kielkowska, Tom N Durrant, Veronique Juvin, Jonathan Clark, Len R Stephens, Phillip T Hawkins

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e58425 (2013)

We disrupted the gene encoding lysophosphatidylinositol-acyltransferase-1 (LPIAT1) in the mouse with the aim of understanding its role in determining cellular phosphoinositide content. LPIAT1(-/-) mice were born at lower than Mendelian ratios and exh

Externí odkaz: https://doaj.org/article/789b26320d9c415eae90d5bb71c19c1b

A small-molecule PI3Kα activator for cardioprotection and neuroregeneration

Autor: Grace Q. Gong, Benoit Bilanges, Ben Allsop, Glenn R. Masson, Victoria Roberton, Trevor Askwith, Sally Oxenford, Ralitsa R. Madsen, Sarah E. Conduit, Dom Bellini, Martina Fitzek, Matt Collier, Osman Najam, Zhenhe He, Ben Wahab, Stephen H. McLaughlin, A. W. Edith Chan, Isabella Feierberg, Andrew Madin, Daniele Morelli, Amandeep Bhamra, Vanesa Vinciauskaite, Karen E. Anderson, Silvia Surinova, Nikos Pinotsis, Elena Lopez-Guadamillas, Matthew Wilcox, Alice Hooper, Chandni Patel, Maria A. Whitehead, Tom D. Bunney, Len R. Stephens, Phillip T. Hawkins, Matilda Katan, Derek M. Yellon, Sean M. Davidson, David M. Smith, James B. Phillips, Richard Angell, Roger L. Williams, Bart Vanhaesebroeck

Publikováno v: Nature. 618:159-168

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8f8e36156cc591a3aec34b2fffc9688
https://doi.org/10.1038/s41586-023-05972-2

In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function

Autor: Tom N. Durrant, James L. Hutchinson, Kate J. Heesom, Karen E. Anderson, Len R. Stephens, Phillip T. Hawkins, Aaron J. Marshall, Samantha F. Moore, Ingeborg Hers

Publikováno v: Blood Advances, Vol 1, Iss 14, Pp 918-932 (2017)

Abstract: The class I phosphoinositide 3-kinase (PI3K) isoforms play important roles in platelet priming, activation, and stable thrombus formation. Class I PI3Ks predominantly regulate cell function through their catalytic product, the signaling pho

Externí odkaz: https://doaj.org/article/0aae918fd93a45f4afea1c0cda863f63

Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase

Autor: Glenn F. W. Walpole, Jonathan Pacheco, Neha Chauhan, Jonathan Clark, Karen E. Anderson, Yazan M. Abbas, Danielle Brabant-Kirwan, Fernando Montaño-Rendón, Zetao Liu, Hongxian Zhu, John H. Brumell, Alexander Deiters, Len R. Stephens, Phillip T. Hawkins, Gerald R. V. Hammond, Sergio Grinstein, Gregory D. Fairn

Publikováno v: Nature Cell Biology. 24:708-722

Despite their low abundance, phosphoinositides play a central role in membrane traffic and signalling. PtdIns(3,4,5)P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d77aec7fe2c7ac16d3ceec8f51a2663
https://doi.org/10.1038/s41556-022-00895-y

The inositol 5-phosphatase INPP5B regulates B cell receptor clustering and signaling

Autor: Alaa Droubi, Connor Wallis, Karen E. Anderson, Saifur Rahman, Aloka de Sa, Taufiq Rahman, Len R. Stephens, Philip T. Hawkins, Martin Lowe

Publikováno v: Droubi, A, Wallis, C, Anderson, K E, Rahman, S, de Sa, A, Rahman, T, Stephens, L R, Hawkins, P T & Lowe, M 2022, ' The inositol 5-phosphatase INPP5B regulates B cell receptor clustering and signaling ', The Journal of cell biology, vol. 221, no. 9, e202112018 . https://doi.org/10.1083/jcb.202112018

Upon antigen binding, the B cell receptor (BCR) undergoes clustering to form a signalosome that propagates downstream signaling required for normal B cell development and physiology. BCR clustering is dependent on remodeling of the cortical actin net

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d261edfb55b4f7a386544c8ff488543
https://doi.org/10.1083/jcb.202112018