Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Len F. Lee"'
Autor:
Kaliappan Iyanar, Jessica D. Dietz, Graciela B. Arhancet, Horng-Chih Huang, Danny J. Garland, Marcia I. Heron, Silvia I. Pomposiello, Xiao Hu, Len F. Lee, Joe T. Collins, Scott S. Woodard, James Robert Blinn, Maria A. Payne, Brenda L. Case, Rhonda S. Woerndle
Publikováno v:
Journal of Medicinal Chemistry. 53:5970-5978
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9288e4053ed7e7f775bce265c4ec3184
https://doi.org/10.1021/jm100506y
https://doi.org/10.1021/jm100506y
Discovery of Potent, Nonsystemic Apical Sodium-Codependent Bile Acid Transporter Inhibitors (Part 2)
Autor:
Miller Raymond E, Wei Huang, Horng-Chih Huang, Jay S. Trivedi, Scott R. Both, Nigam P. Rath, David B. Reitz, Deborah A. Mischke, Len F. Lee, Samuel J. Tremont, Steve R. Rapp, Danny J. Garland, Claude Jones, Banerjee Shyamal C, Matthew W. Mahoney, Theresa Fletcher, Michael B. Tollefson, Karen Regina, Emily J. Reinhard, Grace M. Wagner, Mark E. Smith, Judy Beaudry, J.-H Li, Kevin C. Glenn, Bradley T. Keller, Robert E. Manning, Kevin J. Koeller, Joe R. Schuh, Kolodziej Steve A, William F. Vernier, Carpenter Andrew J, Ching-Cheng Wang
Publikováno v:
Journal of Medicinal Chemistry. 48:5853-5868
In the preceding paper several compounds were reported as potent apical sodium-codependent bile acid transporter (ASBT) inhibitors. Since the primary site for active bile acid reabsorption is via ASBT, which is localized on the luminal surface of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8126ad3914a164ee565779032f3a9bd
https://doi.org/10.1021/jm0402162
https://doi.org/10.1021/jm0402162
Discovery of Potent, Nonsystemic Apical Sodium-Codependent Bile Acid Transporter Inhibitors (Part 1)
Autor:
Len F. Lee, James C. B. Li, William F. Vernier, Samuel J. Tremont, Miller Raymond E, Claude Jones, Wei Huang, Kevin J. Koeller, Robert E. Manning, Andrew J. Carpenter, Mark E. Smith, Scott R. Both, Nigam P. Rath, Joe R. Schuh, Michael B. Tollefson, Jay S. Trivedi, Danny J. Garland, Emily J. Reinhard, Deborah A. Mischke, Karen Regina, David B. Reitz, Grace M. Wagner, Ching-Cheng Wang, Kolodziej Steve A, Kevin C. Glenn, Keller Bradley T, Steve R. Rapp, Banerjee Shyamal C, Theresa R. Fletcher, Horng-Chih Huang, Judy Beaudry, Matthew W. Mahoney
Publikováno v:
Journal of Medicinal Chemistry. 48:5837-5852
Elevated plasma levels of low-density lipoprotein (LDL) cholesterol are a major risk factor for atherosclerosis leading to coronary artery disease (CAD), which remains the main cause of mortality in Western society. We believe that by preventing the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0eb4d79f2a819622faa896314c94f38
https://doi.org/10.1021/jm040215+
https://doi.org/10.1021/jm040215+
Autor:
Deborah Heuvelman, Shridhar Hegde, Mark Baganoff, Len F. Lee, Kevin L. Duffin, Alan R. Tall, Daniel T. Connolly, Elaine S. Krul, Heidi Rath Hope, Christine E. Smith, Roger J. Schilling, Bryan J. Witherbee, Jeffery A. Zablocki, Can Bruce, Kevin C. Glenn
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 10, Pp 1604-1614 (2000)
SC-71952, a substituted analog of dithiobisnicotinic acid dimethyl ester, was identified as a potent inhibitor of cholesteryl ester transfer protein (CETP). When tested in an in vitro assay, the concentration of SC-71952 required for half-maximal inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba767d7427c59c9ee428099a60219643
http://www.sciencedirect.com/science/article/pii/S0022227520319933
http://www.sciencedirect.com/science/article/pii/S0022227520319933
Publikováno v:
The Journal of Organic Chemistry. 65:2711-2715
A highly enantioselective synthesis of benzothiepine 1a has been accomplished via an enantioenriched sulfoxide intermediate obtained by asymmetric oxidation with a chiral oxaziridine in 89:11 er. The key step is a thermodynamically controlled asymmet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98967fad701251e3aa347c0250574edb
https://doi.org/10.1021/jo991786q
https://doi.org/10.1021/jo991786q
Autor:
Len F. Lee, Steven W. Kramer, A. W. Veenhuizen, Carol M. Koboldt, Paul W. Collins, Yan Y. Zhang, Peter C. Isakson, Karen Seibert, Thomas D. Penning
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2121-2124
A series of 3,4-diarylpyrazoles was synthesized and evaluated for their ability to selectively inhibit cyclooxygenase-2 (COX-2). A number of potent and selective inhibitors were identified and found to have oral anti-inflammatory activity in a rat ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::479d32fe6815640e8bcff985c1ac75d3
https://doi.org/10.1016/s0960-894x(97)00372-7
https://doi.org/10.1016/s0960-894x(97)00372-7
Publikováno v:
ChemInform. 31
A highly enantioselective synthesis of benzothiepine 1a has been accomplished via an enantioenriched sulfoxide intermediate obtained by asymmetric oxidation with a chiral oxaziridine in 89:11 er. The key step is a thermodynamically controlled asymmet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7b4b468aec3b88ca7f9cc9496b2c77e
https://doi.org/10.1002/chin.200033024
https://doi.org/10.1002/chin.200033024
Autor:
Gina L. Stikes, Len F. Lee, Larry Y. L. Sing, Jean E. Normansell, Mark G. Dolson, Susan Moritz Auinbauh, Maria L. Miller
Publikováno v:
Pesticide Science. 31:555-568
A new class of fluoroalkylated pyridine herbicides has been discovered. The 3,5-pyridinedicarboxylates are prepared either from ethyl 4,4,4-trifluoroacetoacetate via Hantzsch dihydropyridine synthesis or from trifluoroacetonitrile via cyclocondensati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::545e02cd9a008e683e6af6e05e0c13d3
https://doi.org/10.1002/ps.2780310409
https://doi.org/10.1002/ps.2780310409
Autor:
Len F. Lee, Jean E. Normansell
Publikováno v:
The Journal of Organic Chemistry. 55:2964-2967
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ff75eea375b9017b5a8a4b8de7a085d
https://doi.org/10.1021/jo00296a077
https://doi.org/10.1021/jo00296a077
Autor:
John P. Chupp, John M. Molyneaux, Gina L. Stikes, Y. Larry Sing, Len F. Lee, Scott S. Woodard
Publikováno v:
The Journal of Organic Chemistry. 55:2872-2877
A series of 2-(trifluoromethyl)-1,4- and -3,4-dihydro-3,5-pyridinedicarboxylates 5a-y and 6a-y undergo an unprecedented dehydrofluorination upon treatment with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), trialkylamines, or 2,6-lutidine to give the corr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a003799e7b84eeb39799120d27619524
https://doi.org/10.1021/jo00296a058
https://doi.org/10.1021/jo00296a058