Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Len Dally"'
Autor:
Robert K. Langat, Bashir Farah, Jackton Indangasi, Simon Ogola, Gloria Omosa-Manyonyi, Omu Anzala, Jean Bizimana, Emmanuel Tekirya, Caroline Ngetsa, Moses Silwamba, Enoch Muyanja, Paramesh Chetty, Maureen Jangano, Nancy Hills, Jill Gilmour, Len Dally, Josephine H. Cox, Peter Hayes
Publikováno v:
African Journal of Laboratory Medicine, Vol 10, Iss 1, Pp e1-e13 (2021)
Background: Standardisation of procedures for performing cellular functional assays across laboratories participating in multicentre clinical trials is key for generating comparable and reliable data. Objective: This article describes the performanc
Externí odkaz:
https://doaj.org/article/6c9c7f3784614754a32056bcac6e0d60
Autor:
Juliet Mpendo, Gaudensia Mutua, Annet Nanvubya, Omu Anzala, Julien Nyombayire, Etienne Karita, Len Dally, Drew Hannaman, Matt Price, Patricia E Fast, Frances Priddy, Huub C Gelderblom, Nancy K Hills
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233151 (2020)
IntroductionIntramuscular electroporation (IM/EP) is a vaccine delivery technique that improves the immunogenicity of DNA vaccines. We evaluated the acceptability and tolerability of electroporation among healthy African study participants.MethodsFor
Externí odkaz:
https://doaj.org/article/2efb4c175e924da3b13da98a24fdcb64
Autor:
Subhra Chakraborty, Clayton Harro, Barbara DeNearing, Jessica Brubaker, Sean Connor, Nicole Maier, Len Dally, Jorge Flores, A Louis Bourgeois, Richard Walker, David A Sack
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 4, p e0006442 (2018)
A reliable and effective human challenge model is needed to help down-select the most promising ETEC vaccines currently under development. Such a model would need to reliably induce diarrhea in a high proportion of volunteers using the lowest possibl
Externí odkaz:
https://doaj.org/article/6e11f92982654decbcbc6177cfb62fa4
Autor:
Sven Kratochvil, Paul F. McKay, Jakub T. Kopycinski, Cynthia Bishop, Peter John Hayes, Luke Muir, Christopher L. Pinder, Deniz Cizmeci, Deborah King, Yoann Aldon, Bruce D. Wines, P. Mark Hogarth, Amy W. Chung, Stephen J. Kent, Kathrin Held, Christof Geldmacher, Len Dally, Nelson S. Santos, Tom Cole, Jill Gilmour, Sarah Fidler, Robin J. Shattock
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
A key aspect to finding an efficacious human immunodeficiency virus (HIV) vaccine is the optimization of vaccine schedules that can mediate the efficient maturation of protective immune responses. In the present study, we investigated the effect of a
Externí odkaz:
https://doaj.org/article/4c3b30ccf3f844fdb4a1bdab3e84d4fd
Autor:
Gaudensia Mutua, Bashir Farah, Robert Langat, Jackton Indangasi, Simon Ogola, Brian Onsembe, Jakub T Kopycinski, Peter Hayes, Nicola J Borthwick, Ambreen Ashraf, Len Dally, Burc Barin, Annika Tillander, Jill Gilmour, Jan De Bont, Alison Crook, Drew Hannaman, Josephine H Cox, Omu Anzala, Patricia E Fast, Marie Reilly, Kundai Chinyenze, Walter Jaoko, Tomáš Hanke
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
We are developing a pan-clade HIV-1 T-cell vaccine HIVconsv, which could complement Env vaccines for prophylaxis and be a key to HIV cure. Our strategy focuses vaccine-elicited effector T-cells on functionally and structurally conserved regions (not
Externí odkaz:
https://doaj.org/article/4f123ec4f6fe44898924201105e4aa3e
Autor:
Juliet Mpendo, Gaudensia Mutua, Julien Nyombayire, Rosine Ingabire, Annet Nanvubya, Omu Anzala, Etienne Karita, Peter Hayes, Jakub Kopycinski, Len Dally, Drew Hannaman, Michael A Egan, John H Eldridge, Kristen Syvertsen, Jennifer Lehrman, Beth Rasmussen, Jill Gilmour, Josephine H Cox, Patricia E Fast, Claudia Schmidt
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134287 (2015)
Strategies to enhance the immunogenicity of DNA vaccines in humans include i) co-administration of molecular adjuvants, ii) intramuscular administration followed by in vivo electroporation (IM/EP) and/or iii) boosting with a different vaccine. Combin
Externí odkaz:
https://doaj.org/article/0b098e849d5f4436a0633fd93265da8e
Autor:
Gloria Omosa-Manyonyi, Juliet Mpendo, Eugene Ruzagira, William Kilembe, Elwyn Chomba, François Roman, Patricia Bourguignon, Marguerite Koutsoukos, Alix Collard, Gerald Voss, Dagna Laufer, Gwynn Stevens, Peter Hayes, Lorna Clark, Emmanuel Cormier, Len Dally, Burc Barin, Jim Ackland, Kristen Syvertsen, Devika Zachariah, Kamaal Anas, Eddy Sayeed, Angela Lombardo, Jill Gilmour, Josephine Cox, Patricia Fast, Frances Priddy
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125954 (2015)
Sequential prime-boost or co-administration of HIV vaccine candidates based on an adjuvanted clade B p24, RT, Nef, p17 fusion protein (F4/AS01) plus a non-replicating adenovirus 35 expressing clade A Gag, RT, Int and Nef (Ad35-GRIN) may lead to a uni
Externí odkaz:
https://doaj.org/article/44cb8cee2d1e45b9b74562d08c0bf833
Autor:
Sanjay Mehendale, Madhuri Thakar, Seema Sahay, Makesh Kumar, Ashwini Shete, Pattabiraman Sathyamurthi, Amita Verma, Swarali Kurle, Aparna Shrotri, Jill Gilmour, Rajat Goyal, Len Dally, Eddy Sayeed, Devika Zachariah, James Ackland, Sonali Kochhar, Josephine H Cox, Jean-Louis Excler, Vasanthapuram Kumaraswami, Ramesh Paranjape, Vadakkuppatu Devasenapathi Ramanathan
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55831 (2013)
STUDY DESIGN: A randomized, double-blind, placebo controlled phase I trial. METHODS: The trial was conducted in 32 HIV-uninfected healthy volunteers to assess the safety and immunogenicity of prime-boost vaccination regimens with either 2 doses of AD
Externí odkaz:
https://doaj.org/article/ffae7051f1b84d1ba64645f461065732
Autor:
Sandhya Vasan, Arlene Hurley, Sarah J Schlesinger, Drew Hannaman, David F Gardiner, Daniel P Dugin, Mar Boente-Carrera, Roselle Vittorino, Marina Caskey, Johanne Andersen, Yaoxing Huang, Josephine H Cox, Tony Tarragona-Fiol, Dilbinder K Gill, Hannah Cheeseman, Lorna Clark, Len Dally, Carol Smith, Claudia Schmidt, Harriet H Park, Jakub T Kopycinski, Jill Gilmour, Patricia Fast, Robert Bernard, David D Ho
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19252 (2011)
DNA-based vaccines have been safe but weakly immunogenic in humans to date.We sought to determine the safety, tolerability, and immunogenicity of ADVAX, a multigenic HIV-1 DNA vaccine candidate, injected intramuscularly by in vivo electroporation (EP
Externí odkaz:
https://doaj.org/article/54e6c0214ce848db98e3291e78e074a0
Autor:
Walter Jaoko, Etienne Karita, Kayitesi Kayitenkore, Gloria Omosa-Manyonyi, Susan Allen, Soe Than, Elizabeth M Adams, Barney S Graham, Richard A Koup, Robert T Bailer, Carol Smith, Len Dally, Bashir Farah, Omu Anzala, Claude M Muvunyi, Jean Bizimana, Tony Tarragona-Fiol, Philip J Bergin, Peter Hayes, Martin Ho, Kelley Loughran, Wendy Komaroff, Gwynneth Stevens, Helen Thomson, Mark J Boaz, Josephine H Cox, Claudia Schmidt, Jill Gilmour, Gary J Nabel, Patricia Fast, Job Bwayo
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12873 (2010)
BackgroundWe conducted a double-blind, randomized, placebo-controlled Phase I study of a recombinant replication-defective adenovirus type 5 (rAd5) vector expressing HIV-1 Gag and Pol from subtype B and Env from subtypes A, B and C, given alone or as
Externí odkaz:
https://doaj.org/article/e14cd23e1bda4c33ac138fcbe3751b52