Výsledky vyhledávání - "Len C. Harrison"

An Introduction to Receptors and Receptor Disorders

Autor: Len C. Harrison, Helena Wachslicht-Rodbard, Klara Megyesi, Phillip Gorden, Jeffrey S. Flier, Michele Muggeo, Robert S. Bar, Jesse Roth, Maxine A. Lesniak

Publikováno v: Experimental Biology and Medicine. 162:3-12

SummaryIn the last decade reliable methods have been introduced to quantitate and characterize receptors for hormones and other biologically interesting ligands. Applied initially to hormone receptors on malignant cells and to androgen-resistant and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8757027184fb66544c2c7e8d517252
https://doi.org/10.3181/00379727-162-40608

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DECREASED BINDING OF INSULIN BY RECEPTORS ON PLACENTAL MEMBRANES FROM DIABETIC MOTHERS

Autor: Stella Clark, R. Nichols, Len C. Harrison, Iain J. East, F. I. R. Martin, T. Billington

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 44:206-209

Specific binding of insulin to microsomal membranes from the placentae of insulin-dependent diabetics was significantly decreased when compared with normals. This was due to an apparent decrease in the concentration of insulin receptors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d946a37faf0094737a4faa5b4369d5b1
https://doi.org/10.1210/jcem-44-1-206

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Insulin sensitivity of adipose tissue in vitro and the response to exogenous insulin in obese human subjects

Autor: Anne P. King-Roach, Len C. Harrison

Publikováno v: Metabolism. 25:1095-1101

tion by adipose tissue in vitro reflects the general state of sensitivity of glucose metabolism to insulin in viva in obese human subjects. The mean values for both K,,, and Kit, in the nondiabetic subjects were significantly different from those in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113d78a249706b800e41ec5444e62d60
https://doi.org/10.1016/0026-0495(76)90017-2

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The human placenta contains two distinct binding and immunoreactive species of insulin-like growth factor-I receptors

Autor: Helen A. Jonas, Len C. Harrison

Publikováno v: Journal of Biological Chemistry. 260:2288-2294

Two species of insulin-like growth factor-I (IGF-I) receptors in human placenta have been delineated on the basis of their immunoreactivity with an autoantiserum (B-2) to the insulin receptor. When all the IGF-I binding sites in solubilized human pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6076e15633d80efad315585f2b383d87
https://doi.org/10.1016/s0021-9258(18)89552-7

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Structural differences between insulin and somatomedin-C/insulin-like growth factor-1 receptors revealed by autoantibodies to the insulin receptor

Autor: Len C. Harrison, Robert C. Baxter, Helen A. Jonas

Publikováno v: Biochemical and Biophysical Research Communications. 109:463-470

Five sera containing autoantibodies to the insulin receptor were used to compare the immunological characteristics of the insulin and the somatomedin-C/insulin-like growth factor-1 receptors of Triton-solubilized human placental membranes. Complete i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5167e9fa4900bce7dafd23f818ca189
https://doi.org/10.1016/0006-291x(82)91744-2

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Insulin binding leads to the formation of covalent (-S-S-) hormone receptor complexes

Autor: Stella Clark, Len C. Harrison

Publikováno v: Journal of Biological Chemistry. 257:12239-12244

The recent finding that the lymphocyte insulin receptor is covalently labeled after '261-insulin binding (Saviolaskis, G., Harrison, L. c., and Roth, J. (1981) J. BioL Chem 256,4924-4928) led us to directly test a previous hypothesis that insulin bin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::286c2f5239b6f0bea5fc77d5e937093f
https://doi.org/10.1016/s0021-9258(18)33706-2

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Autoantibodies to thyroid hormones: Association with falsely low hormone levels measured by ‘Amerlex’ assay

Autor: Paula Heyma, Len C. Harrison

Publikováno v: Clinica Chimica Acta. 161:239-242

Autoantibodies to thyroxine (T4) and tri-iodothyronine (T3) were found in a 21-yr-old thyrotoxic woman who had paradoxically low T4 and T3 as measured in the 'Amerlex' solid phase radio-immunoassay. Though rare, thyroid hormone antibodies should be s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44088fff145897f9156816683999b3a1
https://doi.org/10.1016/0009-8981(86)90217-2

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Inhibition of tumor size by streptozotocin-induced diabetes mellitus

Autor: Murray F. Brennan, Gerald M. Sloan, Len C. Harrison, Lisa H. Underhill

Publikováno v: Journal of Surgical Research. 30:463-472

The effects of experimental diabetes mellitus on tumor growth were studied. Male Fischer rats were rendered diabetic with a single intravenous injection of streptozotocin. Ten days later they were inoculated with 10 6 cells of a methylcholanthrene-in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd480fbee520ccd8c632afb5f78a6057
https://doi.org/10.1016/0022-4804(81)90091-3

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