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pro vyhledávání: '"Lemon Bryan D"'
Akademický článek
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Autor:
Lemon Bryan D, Manasi Barath, Che-Leung Law, Robert B. Dubridge, Kenneth Sexton, Richard J. Austin, Stephen Yu, Timothy Yu, Purbasa Patnaik, Patrick A. Baeuerle, A. Jones, Anand Panchal, Luke Evnin, Russell Wall, Patricia Culp, Kathryn L. Strobel, Pui Seto, Vanitha Ramakrishnan, Holger Wesche, Wade Aaron, Sony Rocha
Publikováno v:
Molecular Cancer Therapeutics. 20:109-120
T cells have a unique capability to eliminate cancer cells and fight malignancies. Cancer cells have adopted multiple immune evasion mechanisms aimed at inhibiting T cells. Dramatically improved patient outcomes have been achieved with therapies gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7405941cbbfa5d733a65e82cb28cafa8
https://doi.org/10.1158/1535-7163.mct-20-0061
https://doi.org/10.1158/1535-7163.mct-20-0061
Autor:
Kevin Wright, Jack Lin, Richard C. Austin, Maria Dayao, Lemon Bryan D, Master Degree, Michael Cremin, Stephen Yu, Purbasa Patnaik, Jessica O’Rear, Holger Wesche, Golzar Hemmati, Sony Rocha, Maria Gamez-Guerrero, Tessie M. Ng, Yinghua Xiao, Avneel Hundal, Scott Gatto, Kathryn Kwant, Tom Evans, Timothy Yu, Manasi Barath, Patrick Chew, Evan Callihan, Wade Aaron
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Epithelial cell adhesion molecule (EpCAM) is highly expressed in many solid tumors. However, therapeutics targeting EpCAM have had limited clinical utility or failed in clinical development likely due to the expression of EpCAM in normal t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e0492817e767fbfa910f853a5faa9b
https://doi.org/10.1136/jitc-2020-sitc2020.0632
https://doi.org/10.1136/jitc-2020-sitc2020.0632
Autor:
Che-Leung Law, Holger Wesche, Timothy Yu, Richard J. Austin, Vaishnavi Ganti, Mary Ellen Molloy, Kathryn L. Strobel, Susan D. Jones, Purbasa Patnaik, Laurie Tatalick, A. Jones, Kenneth Sexton, Patrick A. Baeuerle, Wade Aaron, Lemon Bryan D
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 27(5)
Purpose: Mesothelin (MSLN) is a glycophosphatidylinositol-linked tumor antigen overexpressed in a variety of malignancies, including ovarian, pancreatic, lung, and triple-negative breast cancer. Early signs of clinical efficacy with MSLN-targeting ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a05654dbacd41d8f81d7ec5c1ac869
https://pubmed.ncbi.nlm.nih.gov/33262134
https://pubmed.ncbi.nlm.nih.gov/33262134
Akademický článek
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Katrina Stephenson, S. Jack Lin, Kevin Wright, Hubert Situ, Richard C. Austin, Lemon Bryan D, Yinghua Xiao, Subramanian Thothathri, Sony Rocha, Holger Wesche, Taggra Jackson, Avneel Hundal, Wade Aaron, Evan Callihan, Linh To, Maria Dayao, Eric Bragg, Willis Kwong, Golzar Hemmati, Timothy Yu, Stephen Yu, Kathryn Kwant, Jessica O’Rear, Rose Banzon
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundCD3-targeted T cell engagers are potent anti-tumor therapies, but their development often requires management of cytokine release syndrome (CRS). Subcutaneous dosing is a promising strategy to reduce CRS, but its application is limited by i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df20fa88b82841bb092b3d42592a0cec
https://doi.org/10.1136/jitc-2021-sitc2021.867
https://doi.org/10.1136/jitc-2021-sitc2021.867
Autor:
Timothy Yu, Raphaela Rose Banzon, Sony Rocha, Holger Wesche, Stephen Yu, Subramanian Thothathri, Yinghua Xiao, Jessica O’Rear, Kathryn Kwant, Kevin Wright, Purbasa Patnaik, Manasi Barath, Richard J. Austin, Avneel Hundal, S. Jack Lin, Golzar Hemmati, Lemon Bryan D, Tessie M. Ng, Scott Gatto, Wade Aaron, Evan Callihan, Linh To, Maria Dayao, Eric Bragg
Publikováno v:
Cancer Research. 81:933-933
T cell engagers have compelling clinical activity, but their use is limited by the availability of tumor targets with minimal normal tissue expression. Conditionally active T cell engagers designed to be active only in the tumor and to spare normal t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c82d09e115f10025f86264aee89fc782
https://doi.org/10.1158/1538-7445.am2021-933
https://doi.org/10.1158/1538-7445.am2021-933
Autor:
Stephen Yu, Kevin M. Wright, Jessica O’Rear, Manasi Barath, Wade Aaron, Lemon Bryan D, Morgan Thompson, Scott Gatto, Evan Callihan, Timothy Yu, Purbasa Patnaik, Holger Wesche, Che-Leung Law, Richard J. Austin, Lihn To, Golzar Hemmati, Yinghua Xiao
Publikováno v:
Cancer Research. 81:913-913
FLT3 (fms related receptor tyrosine kinase 3) is a cell surface protein expressed in hematopoietic stem and progenitor cell populations1. FLT3 RNA is overexpressed in greater than 95% of acute myeloid leukemia (AML) samples2, and FLT3 mutations are f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89d12e21da0bce7ca52255eafb28b34c
https://doi.org/10.1158/1538-7445.am2021-913
https://doi.org/10.1158/1538-7445.am2021-913
Autor:
Lisa Knapp, Eva Medvedova, Henning Schade, Rajneesh Nath, Sumit Madan, Liping Laura Sun, Lemon Bryan D
Publikováno v:
Blood. 136:10-10
Background B cell maturation antigen (BCMA) has emerged as a promising target for multiple myeloma (MM) therapies based on its restricted expression profile and functional role in promoting MM cell survival. Some of these BCMA targeting molecules, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57b620ef20cd6cf188ba2a0debf6e9f9
https://doi.org/10.1182/blood-2020-136012
https://doi.org/10.1182/blood-2020-136012