Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Lemlem Alemu"'
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Akademický článek
Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells
Autor: Shouguo Gao, Zhijie Wu, Bradley Arnold, Carrie Diamond, Sai Batchu, Valentina Giudice, Lemlem Alemu, Diego Quinones Raffo, Xingmin Feng, Sachiko Kajigaya, John Barrett, Sawa Ito, Neal S. Young
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
T cell large granular lymphocyte leukemia (T-LGLL) and the cellular phenotype underlying response to therapy is not well understood. Here the authors use single cell sequencing to better understand changes in T cell clonal frequency and gene expressi
Externí odkaz: https://doaj.org/article/1ce0e22e576f438dbecefabc1c9dfca4
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3
Analysis of deficiency of adenosine deaminase 2 pathogenesis based on single-cell RNA sequencing of monocytes
Autor: Patrycja Hoffmann, Neal S. Young, Amanda K. Ombrello, Shouguo Gao, Carrie Diamond, Naoki Watanabe, Zhijie Wu, Sai Batchu, Lemlem Alemu, Diego Quinones Raffo, Sachiko Kajigaya, Deborah L. Stone
Publikováno v: Journal of Leukocyte Biology. 110:409-424
Deficiency of adenosine deaminase 2 (DADA2) is a rare autosomal recessive disease caused by loss-of-function variants in the ADA2 gene. DADA2 typically presents in childhood and is characterized by vasculopathy, stroke, inflammation, immunodeficiency
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da22a735bd66292897e384d425e77fe6
https://doi.org/10.1002/jlb.3hi0220-119rr
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5
Single-cell profiling of T lymphocytes in deficiency of adenosine deaminase 2
Autor: Diego Quinones Raffo, Shouguo Gao, Xingmin Feng, Patrycja Hoffmann, Zhijie Wu, Carrie Diamond, Amanda K. Ombrello, Sai Batchu, Sachiko Kajigaya, Neal S. Young, Lemlem Alemu, Naoki Watanabe, Deborah L. Stone
Publikováno v: Journal of leukocyte biologyREFERENCES. 111(2)
Deficiency of adenosine deaminase 2 (DADA2) is a monogenic vasculitis syndrome caused by autosomal-recessive loss-of-function mutations in the ADA2 gene (previously known as CECR1). Vasculitis, vasculopathy, and inflammation are dominant clinical fea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1ea954b31bb12ffca785aa7c9c351b
https://pubmed.ncbi.nlm.nih.gov/35090065
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6
RUNX1 and CBFβ-SMMHC transactivate target genes together in abnormal myeloid progenitors for leukemia development
Autor: Guadalupe Lopez, Pengfei Liu, Dechun Feng, Lemlem Alemu, R. Katherine Hyde, Yaqiang Cao, Tao Zhen, Ling Zhao, Gang Ren, Keji Zhao
Publikováno v: Blood
Inversion of chromosome 16 is a consistent finding in patients with acute myeloid leukemia subtype M4 with eosinophilia, which generates a CBFB-MYH11 fusion gene. It is generally considered that CBFβ-SMMHC, the fusion protein encoded by CBFB-MYH11,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd63b82a760b475b9fff8459417de7cd
https://pubmed.ncbi.nlm.nih.gov/33211836
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7
Deficit of circulating CD19
Autor: Xingmin Feng, Diego Quinones Raffo, Lemlem Alemu, Bhavisha A Patel, Neal S. Young, Emma M. Groarke, Yoshitaka Zaimoku, Sachiko Kajigaya
Publikováno v: British Journal of Haematology
Immune aplastic anaemia (AA) is caused by cytotoxic T lymphocytes (CTLs) that destroy haematopoietic stem and progenitor cells. Enhanced type 1 T helper (Th1) responses and reduced regulatory T cells (Tregs) are involved in the immune pathophysiology
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b2a420f3d56b70fc1c609d73d1f883
https://pubmed.ncbi.nlm.nih.gov/32583450
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8
Clonal Hematopoiesis in Telomere Biology Disorders Associates with the Underlying Germline Defect and Somatic Mutations in POT1, PPM1D, and TERT promoter
Autor: Fernanda Gutierrez-Rodrigues, Flavia S. Donaires, Barbara A. Santana, Neal S. Young, Emma M. Groarke, Lemlem Alemu, Rodrigo T. Calado, Carmem Bonfim, Nina Spitofsky, Diego V. Clé, Bhavisha A Patel, Sachiko Kajigaya, Simona Colla, M.M. Oliveira
Publikováno v: Blood. 138:1111-1111
Introduction: Telomere biology (TBD) disorders are caused by pathogenic germline variants in genes related to telomere maintenance. In TBD, clonal hematopoiesis (CH) has been hypothesized to compensate for restricted cell fitness and to lead to devel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab29b01355b6d8392d179106fd0e91ce
https://doi.org/10.1182/blood-2021-151199
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9
Chd7 deficiency delays leukemogenesis in mice induced by Cbfb-MYH11
Autor: Lemlem Alemu, Jingmei Hsu, Ling Zhao, Pengfei Liu, Erika M. Kwon, Tao Zhen, R. Katherine Hyde, Ying Lu, Nancy A. Speck
Publikováno v: Blood. 130:2431-2442
Inversion of chromosome 16 is a consistent finding in patients with acute myeloid leukemia subtype M4 with eosinophilia, which generates a CBFB-MYH11 fusion gene. Previous studies showed that the interaction between CBFβ-smooth muscle myosin heavy c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9352bb536a735013db84ba83d582cd93
https://doi.org/10.1182/blood-2017-04-780106
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10
Analysis of Deficiency of Adenosine Deaminase 2 Pathogenesis Based on Single Cell RNA Sequencing of Monocytes
Autor: Neal S. Young, Naoki Watanabe, Sachiko Kajigaya, Carrie Diamond, Lemlem Alemu, Shouguo Gao, Amanda K. Ombrello
Publikováno v: Blood. 134:2317-2317
Deficiency of adenosine deaminase 2 (DADA2) is a rare autosomal recessive disease caused by loss-of-function mutations in the ADA2 gene. DADA2 typically presents in childhood and is characterized by vasculopathy, stroke, inflammation, and immunodefic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd244ad8c927231031d1425b699c5ed5
https://doi.org/10.1182/blood-2019-123859
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