Refined innate plasma signature after rVSVΔG-ZEBOV-GP immunization is shared among adult cohorts in Europe and North America

Autor: Paola Andrea Martinez-Murillo, Angela Huttner, Sylvain Lemeille, Donata Medaglini, Tom H. M. Ottenhoff, Ali M. Harandi, Arnaud M. Didierlaurent, Claire-Anne Siegrist

Publikováno v: Frontiers in Immunology, Vol 14 (2024)

BackgroundDuring the last decade Ebola virus has caused several outbreaks in Africa. The recombinant vesicular stomatitis virus-vectored Zaire Ebola (rVSVΔG-ZEBOV-GP) vaccine has proved safe and immunogenic but is reactogenic. We previously identifi

Externí odkaz: https://doaj.org/article/5b61e612437449d2b52c65274854f678

Data quality control considerations in multivariate environmental monitoring: experience of the French coastal network SOMLIT

Autor: Elsa Breton, Nicolas Savoye, Peggy Rimmelin-Maury, Benoit Sautour, Eric Goberville, Arnaud Lheureux, Thierry Cariou, Sophie Ferreira, Hélène Agogué, Samir Alliouane, Fabien Aubert, Sébastien Aubin, Eric Berthebaud, Hadrien Blayac, Lucie Blondel, Cédric Boulart, Yann Bozec, Sarah Bureau, Arnaud Caillo, Arnaud Cauvin, Jean-Baptiste Cazes, Léo Chasselin, Pascal Claquin, Pascal Conan, Marie-Ange Cordier, Laurence Costes, Romain Crec’hriou, Olivier Crispi, Muriel Crouvoisier, Valérie David, Yolanda Del Amo, Hortense De Lary, Gaspard Delebecq, Jeremy Devesa, Aurélien Domeau, Maria Durozier, Claire Emery, Eric Feunteun, Juliette Fauchot, Valérie Gentilhomme, Sandrine Geslin, Mélanie Giraud, Karine Grangeré, Gerald Grégori, Emilie Grossteffan, Aurore Gueux, Julien Guillaudeau, Gael Guillou, Manon Harrewyn, Orianne Jolly, Florence Jude-Lemeilleur, Paul Labatut, Nathalie Labourdette, Nicolas Lachaussée, Michel Lafont, Veronique Lagadec, Christophe Lambert, Jezebel Lamoureux, Laurent Lanceleur, Benoit Lebreton, Eric Lecuyer, David Lemeille, Yann Leredde, Cédric Leroux, Aude Leynaert, Stéphane L’Helguen, Camilla Liénart, Eric Macé, Eric Maria, Barbara Marie, Dominique Marie, Sébastien Mas, Fabrice Mendes, Line Mornet, Behzad Mostajir, Laure Mousseau, Antoine Nowaczyk, Sandra Nunige, René Parra, Thomas Paulin, David Pecqueur, Franck Petit, Philippe Pineau, Patrick Raimbault, Fabienne Rigaut-Jalabert, Christophe Salmeron, Ian Salter, Pierre-Guy Sauriau, Laurent Seuront, Emmanuelle Sultan, Rémi Valdès, Vincent Vantrepotte, Francesca Vidussi, Florian Voron, Renaud Vuillemin, Laurent. Zudaire, Nicole Garcia

Publikováno v: Frontiers in Marine Science, Vol 10 (2023)

IntroductionWhile crucial to ensuring the production of accurate and high-quality data—and to avoid erroneous conclusions—data quality control (QC) in environmental monitoring datasets is still poorly documented.MethodsWith a focus on annual inte

Externí odkaz: https://doaj.org/article/bccfad75e55247ff95e0666db9c72da8

Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling

Autor: Nicolas Page, Sylvain Lemeille, Ilena Vincenti, Bogna Klimek, Alexandre Mariotte, Ingrid Wagner, Giovanni Di Liberto, Jonathan Kaye, Doron Merkler

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

The transcriptional adaptation processes of harmful self-reactive CD8+ T cells in the central nervous system are not well understood. Here the authors use a system in which self-reactive and virally generated CD8+ T cells are directly compared in viv

Externí odkaz: https://doaj.org/article/0a1022f34c2d437e8a387d622d23d03f

Despite great expectations in the Seine River Basin, the WFD did not reduce diffuse pollution

Autor: Gabrielle Bouleau, Rémi Barbier, Marie-Pierre Halm-Lemeille, Bruno Tassin, Arnaud Buchs, Florence Habets

Publikováno v: Water Alternatives, Vol 13, Iss 3, Pp 534-555 (2020)

European stakeholders engaged in combatting the eutrophication of the North Sea welcomed three Water Framework Directive innovations: a more holistic approach to quality, the binding nature of WFD objectives, and greater public participation. Twenty

Externí odkaz: https://doaj.org/article/98156210dbb64b769e5cb1f93bd6973c

Robust innate responses to SARS-CoV-2 in children resolve faster than in adults without compromising adaptive immunity

Autor: Maria Vono, Angela Huttner, Sylvain Lemeille, Paola Martinez-Murillo, Benjamin Meyer, Stephanie Baggio, Shilpee Sharma, Anais Thiriard, Arnaud Marchant, Gert-Jan Godeke, Chantal Reusken, Catia Alvarez, Francisco Perez-Rodriguez, Isabella Eckerle, Laurent Kaiser, Natasha Loevy, Christiane S. Eberhardt, Geraldine Blanchard-Rohner, Claire-Anne Siegrist, Arnaud M. Didierlaurent

Publikováno v: Cell Reports, Vol 37, Iss 1, Pp 109773- (2021)

Summary: SARS-CoV-2 infection in children is less severe than it is in adults. We perform a longitudinal analysis of the early innate responses in children and adults with mild infection within household clusters. Children display fewer symptoms than

Externí odkaz: https://doaj.org/article/a59d830bfb744dbdb573de8b4bfd4c00