Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca ²⁺ release to protect stressed replication forks.

Autor: Li S; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Hepatobiliary and Pancreatic Surgery and Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China., Kong L; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Meng Y; Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China., Cheng C; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Lemacon DS; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Yang Z; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Tan K; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Cheruiyot A; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Lu Z; Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China., You Z; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: zyou@wustl.edu.

Publikováno v: Molecular cell [Mol Cell] 2023 Feb 16; Vol. 83 (4), pp. 556-573.e7. Date of Electronic Publication: 2023 Jan 24.

Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring SF3B1 or U2AF1 Mutations.

Autor: Cheruiyot A; Department of Cell Biology and Physiology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri., Li S; Department of Cell Biology and Physiology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri., Nonavinkere Srivatsan S; Division of Hematology and Oncology, Department of Medicine, School of Medicine, Washington University School in St. Louis, St. Louis, Missouri., Ahmed T; Division of Hematology and Oncology, Department of Medicine, School of Medicine, Washington University School in St. Louis, St. Louis, Missouri., Chen Y; Department of Radiation Oncology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri., Lemacon DS; Department of Cell Biology and Physiology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri., Li Y; Department of Cell Biology and Physiology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri.; Clinical Biobank, The Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, P.R. China., Yang Z; Department of Cell Biology and Physiology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri.; Department of Urology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, China., Wadugu BA; Division of Hematology and Oncology, Department of Medicine, School of Medicine, Washington University School in St. Louis, St. Louis, Missouri., Warner WA; Division of Hematology and Oncology, Department of Medicine, School of Medicine, Washington University School in St. Louis, St. Louis, Missouri., Pruett-Miller SM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Obeng EA; Molecular Oncology Division, St. Jude Children's Research Hospital, Memphis, Tennessee., Link DC; Division of Hematology and Oncology, Department of Medicine, School of Medicine, Washington University School in St. Louis, St. Louis, Missouri., He D; Department of Urology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, China., Xiao F; Clinical Biobank, The Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, P.R. China., Wang X; Department of Radiation Oncology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri., Bailis JM; Oncology Research, Amgen Inc, Thousand Oaks, California., Walter MJ; Division of Hematology and Oncology, Department of Medicine, School of Medicine, Washington University School in St. Louis, St. Louis, Missouri., You Z; Department of Cell Biology and Physiology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri. zyou@wustl.edu.

Publikováno v: Cancer research [Cancer Res] 2021 Sep 01; Vol. 81 (17), pp. 4499-4513. Date of Electronic Publication: 2021 Jul 02.