Increased hepatic PDGF-AA signaling mediates liver insulin resistance in obesity associated type 2 diabetes

Autor: Abderrahmani, Amar, Yengo, Loic, Caiazzo, Robert, Canouil, Mickael, Cauchi, Stephane, Raverdy, Violeta, Plaisance, Valerie, Pawlowski, Valerie, Lobbens, Stephane, Maillet, Julie, Rolland, Laure, Boutry, Raphael, Queniat, Gurvan, Kwapich, Maxime, Tenenbaum, Mathie, Bricambert, Julien, Saussenthaler, Sophie, Anthony, Elodie, Jha, Pooja, Derop, Julien, Sand, Olivier, Rabearivelo, Iandry, Leloire, Audrey, Pigeyre, Marie, Daujat-Chavanieu, Martine, Gerbal-Chaloin, Sabine, Dayeh, Tasnim, Lassailly, Guillaume, Mathurin, Philippe, Staels, Bart, Auwerx, Johan, Schurmann, Annette, Postic, Catherine, Schafmayer, Clemens, Hampe, Jochen, Bonnefond, Amelie, Pattou, Francois, Froguel, Philippe

Type 2 diabetes (T2D) is closely linked with non-alcoholic fatty liver disease (NAFLD) and hepatic insulin resistance, but the involved mechanisms are still elusive. Using DNA methylome and transcriptome analyses of livers from obese individuals, we

Externí odkaz: http://arxiv.org/abs/1712.04680

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Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles

Autor: Verbanck, Marie, Canouil, Mickaël, Leloire, Audrey, Dhennin, Véronique, Coumoul, Xavier, Yengo, Loïc, Froguel, Philippe, Poulain-Godefroy, Odile

Publikováno v: PLoS ONE
PLoS ONE, 2017, 12 (6), pp.e0179583. ⟨10.1371/journal.pone.0179583⟩
PLoS ONE, Vol 12, Iss 6, p e0179583 (2017)
PLoS ONE, Public Library of Science, 2017, 12 (6), pp.e0179583. ⟨10.1371/journal.pone.0179583⟩

International audience; Bisphenol A (BPA) exposure has been suspected to be associated with deleterious effects on health including obesity and metabolically-linked diseases. Although bisphenols F (BPF) and S (BPS) are BPA structural analogs commonly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a2fd90041164d44496bd9ddfefcca1f8
https://hal.science/hal-02196318/file/article.pdf

Regularised PCA to denoise and visualise data

Autor: Favennec, Marie, Hennart, Benjamin, Caiazzo, Robert, Leloire, Audrey, Yengo, Loïc, Verbanck, Marie, Arredouani, Abdelilah, Marre, Michel, Pigeyre, Marie, Bessede, Alban, Guillemin, Gilles, Chinetti, Giulia, Staels, Bart, Pattou, François, Balkau, Beverley, Allorge, Delphine, Froguel, Philippe, Poulain-Godefroy, Odile

Publikováno v: Obesity
Obesity, 2015, 23 (10), pp.2066-2074. ⟨10.1002/oby.21199⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3b40d8b9748895b4b6f24734bcbb9f5d
https://hal.science/hal-03837251

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