Zobrazeno 1 - 10
of 590
pro vyhledávání: '"Lelliott, P."'
Autor:
Tracy-Shi Zhang Fang, Yu Sun, Andrew C. Pearce, Simona Eleuteri, Mark Kemp, Christopher A. Luckhurst, Rachel Williams, Ross Mills, Sarah Almond, Laura Burzynski, Nóra M. Márkus, Christopher J. Lelliott, Natasha A. Karp, David J. Adams, Stephen P. Jackson, Jin-Feng Zhao, Ian G. Ganley, Paul W. Thompson, Gabriel Balmus, David K. Simon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Mutations in SNCA, the gene encoding α-synuclein (αSyn), cause familial Parkinson’s disease (PD) and aberrant αSyn is a key pathological hallmark of idiopathic PD. This α-synucleinopathy leads to mitochondrial dysfunction, which may dr
Externí odkaz:
https://doaj.org/article/231adfbea4cd447195e9caff8d44823d
Autor:
Patrick Michael Lelliott, Alison Jane Hobro, Nicolas Pavillon, Masayuki Nishide, Yasutaka Okita, Yumiko Mizuno, Sho Obata, Shinichiro Nameki, Hanako Yoshimura, Atsushi Kumanogoh, Nicholas Isaac Smith
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract The defining biology that distinguishes neutrophil extracellular traps (NETs) from other forms of cell death is unresolved, and techniques which unambiguously identify NETs remain elusive. Raman scattering measurement provides a holistic ove
Externí odkaz:
https://doaj.org/article/14ad017e13094cc48028352bc6949fa8
Akademický článek
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Akademický článek
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Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-5 (2022)
Abstract CDK4/6 inhibitors (CDK4/6i) were developed as a cancer therapeutic on the basis of their tumor-intrinsic cytostatic potential, but have since demonstrated profound activity as immunomodulatory agents. While currently approved to treat hormon
Externí odkaz:
https://doaj.org/article/d3b830639fb54c8e817359ba791b5397
Autor:
Lorey K. Smith, Tiffany Parmenter, Margarete Kleinschmidt, Eric P. Kusnadi, Jian Kang, Claire A. Martin, Peter Lau, Riyaben Patel, Julie Lorent, David Papadopoli, Anna Trigos, Teresa Ward, Aparna D. Rao, Emily J. Lelliott, Karen E. Sheppard, David Goode, Rodney J. Hicks, Tony Tiganis, Kaylene J. Simpson, Ola Larsson, Benjamin Blythe, Carleen Cullinane, Vihandha O. Wickramasinghe, Richard B. Pearson, Grant A. McArthur
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Different adaptive mechanisms have been reported to reduce the efficacy of mutant BRAF inhibition in melanoma. Here, the authors show BRAF inhibition induces the translational regulation of metabolic genes leading to acquired therapy resistance.
Externí odkaz:
https://doaj.org/article/059612c027f74f17b5f4fdc038786683
Autor:
Nick Sevdalis, Andrew Walker, Natasha Curran, Sally Irwin, Louise Goff, Sophie Lowry, Oliver Brady, Zoe Lelliott
Publikováno v:
BMJ Open, Vol 12, Iss 11 (2022)
Introduction The National Health Service Insight Prioritisation Programme was established to accelerate the implementation and evaluation of innovation that supports post-pandemic working. Supporting this, the Academic Health Science Network and Nati
Externí odkaz:
https://doaj.org/article/18edc9ea85584348bca1f64f0b90f9c4
Autor:
Yi-Hsuan Lin, Ethan Sahker, Kiyomi Shinohara, Noboru Horinouchi, Masami Ito, Madoka Lelliott, Andrea Cipriani, Anneka Tomlinson, Christopher Baethge, Toshi A. Furukawa
Publikováno v:
EClinicalMedicine, Vol 50, Iss , Pp 101505- (2022)
Summary: Background: In double-blind randomized controlled trials (RCTs) of antidepressants, blinding can be broken due to the apparent side effects, and unsuccessful blinding can lead to overestimation of effect sizes. New generation antidepressants
Externí odkaz:
https://doaj.org/article/0791e416818948de96e23aeb835631a7
Autor:
Emily J. Lelliott, Kelly M. Ramsbottom, Mark R. Dowling, Carolyn Shembrey, Tahereh Noori, Conor J. Kearney, Jessica Michie, Ian A. Parish, Margaret A. Jordan, Alan G. Baxter, Neil D. Young, Amelia J. Brennan, Jane Oliaro
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cytotoxic lymphocytes are essential for anti-tumor immunity, and for effective responses to cancer immunotherapy. Natural killer cell granule protein 7 (NKG7) is expressed at high levels in cytotoxic lymphocytes infiltrating tumors from patients trea
Externí odkaz:
https://doaj.org/article/c8e517cb608a45a58a1cfaec14b8b317
Autor:
Scott E. Youlten, John P. Kemp, John G. Logan, Elena J. Ghirardello, Claudio M. Sergio, Michael R. G. Dack, Siobhan E. Guilfoyle, Victoria D. Leitch, Natalie C. Butterfield, Davide Komla-Ebri, Ryan C. Chai, Alexander P. Corr, James T. Smith, Sindhu T. Mohanty, John A. Morris, Michelle M. McDonald, Julian M. W. Quinn, Amelia R. McGlade, Nenad Bartonicek, Matt Jansson, Konstantinos Hatzikotoulas, Melita D. Irving, Ana Beleza-Meireles, Fernando Rivadeneira, Emma Duncan, J. Brent Richards, David J. Adams, Christopher J. Lelliott, Robert Brink, Tri Giang Phan, John A. Eisman, David M. Evans, Eleftheria Zeggini, Paul A. Baldock, J. H. Duncan Bassett, Graham R. Williams, Peter I. Croucher
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Osteocytes are the master regulatory cells within the skeleton. Here, the authors map the transcriptome of osteocytes from diverse skeletal sites, ages and between sexes and identify an osteocyte transcriptome signature associated with rare skeletal
Externí odkaz:
https://doaj.org/article/60182d9a653b4b4d9d0b7b34378bcb3e