Zobrazeno 1 - 10
of 486
pro vyhledávání: '"Lelio Orci"'
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46293 (2012)
Besides its role in controlling the morphology of mitochondria, mitofusin-2 has been proposed to tether mitochondria to the endoplasmic reticulum (ER), based largely on light microscopic analysis. In this study we have examined by electron microscopy
Externí odkaz:
https://doaj.org/article/b1c9a214dff2453997ac5e6af6d6c84a
Autor:
Pierre Cosson, Lelio Orci, Nicolas Demaurex, Philipp E. Scherer, Manon Rosselin, Anna Marchetti, Alexandre Vernay, Tania Jauslin, Ayman Sabra
Publikováno v:
Proceedings of the National Academy of Sciences, Vol. 114, No 31 (2017) pp. 8277-8282
MitoNEET (mNEET) is a dimeric mitochondrial outer membrane protein implicated in many facets of human pathophysiology, notably diabetes and cancer, but its molecular function remains poorly characterized. In this study, we generated and analyzed mNEE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230f1e871c497ed42ea2032bbd9fae63
https://archive-ouverte.unige.ch/unige:100203
https://archive-ouverte.unige.ch/unige:100203
Autor:
Lelio Orci, Roger H Unger
Publikováno v:
Proceedings of the National Academy of Sciences. 107:16009-16012
New results have brought to light the importance of the regulation of glucagon by β-cells in the development of diabetes. In this perspective, we examine the normal paracrinology of α- and β-cells in nondiabetic pancreatic islets. We propose a She
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690883e6789564f4967ee291d460d774
https://doi.org/10.1073/pnas.1006639107
https://doi.org/10.1073/pnas.1006639107
Autor:
Pierre Cosson, James E. Rothman, Felix T. Wieland, Mariella Ravazzola, Lelio Orci, Lei Shi, Michael Geiling, Grégory Lavieu
Publikováno v:
Proceedings of the National Academy of Sciences, Vol. 107, No 15 (2010) pp. 6876-6881
Cortical endoplasmic reticulum (cER) is a permanent feature of yeast cells but occurs transiently in most animal cell types. Ist2p is a transmembrane protein that permanently localizes to the cER in yeast. When Ist2 is expressed in mammalian cells, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db911bab484d9af2c9ce4c887ecda449
https://doi.org/10.1073/pnas.1002536107
https://doi.org/10.1073/pnas.1002536107
Publikováno v:
Trends in Cell Biology. 18:330-336
Coat protein complex II (COPII) is a multi-subunit protein complex responsible for the formation of membrane vesicles at the endoplasmic reticulum. The assembly of this complex on the endoplasmic reticulum membrane needs to be tightly regulated to en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1341f4b33b66e36665d88a41a9ff1df
https://doi.org/10.1016/j.tcb.2008.04.006
https://doi.org/10.1016/j.tcb.2008.04.006
Autor:
Arthur A Like, A.E. Lambert, Benigna Blondel, Lelio Orci, Claes B. Wollheim, Albert E. Renold, Errol B. Marliss, W. Stauffacher
Publikováno v:
European Journal of Clinical Investigation. 3:16-26
Monolayer culture of pancreatic cells from newborn rats has been shown to yield ultrastructurally normal endocrine cells, virtual absence of differentiated exocrine cells, and the maintenance of the capacity to synthesize immuno-reactive insulin (IRI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d92dc8d7b6e07777df059f84ad6a53
https://doi.org/10.1111/j.1365-2362.1973.tb00324.x
https://doi.org/10.1111/j.1365-2362.1973.tb00324.x
Autor:
Randy Schekman, Mohammed Al-Balwi, Mariella Ravazzola, Lelio Orci, Wafaa Eyaid, Susan Hamamoto, Simeon A. Boyadjiev, Pierre Cosson, J. Christopher Fromme
Publikováno v:
Developmental Cell, Vol. 13, No 5 (2007) pp. 623-34
SummaryProteins trafficking through the secretory pathway must first exit the endoplasmic reticulum (ER) through membrane vesicles created and regulated by the COPII coat protein complex. Cranio-lenticulo-sutural dysplasia (CLSD) was recently shown t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4870f7fd757005aed17a3211a481d20
Publikováno v:
Circulation Research. 101:759-767
Until 60 years ago, fatty heart was an accepted clinical entity. Since then, its very existence has been questioned, despite the fact that 2 of 3 Americans are now obese or overweight and obesity has been shown to be correlated with cardiac functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6a5850e210eedde3c2990dec30fc1e
https://doi.org/10.1161/circresaha.107.160457
https://doi.org/10.1161/circresaha.107.160457
Autor:
Young H Lee, Byung Hyun Park, Roger H Unger, Yuriy K. Bashmakov, Lelio Orci, Mariella Ravazzola
Publikováno v:
Diabetes. 56:2295-2301
The objective of this study was to determine whether the late failure of β-cells in islets transplanted via the portal vein is caused by excess insulin-stimulated lipogenesis and lipotoxicity and, if so, whether the damage can be prevented by reduci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01f4c3416ab4e8c727282f45be5dccfd
https://doi.org/10.2337/db07-0460
https://doi.org/10.2337/db07-0460
Autor:
Maud Frieden, Pierre Cosson, Sophie Saüc, Lelio Orci, Laurent Bernheim, Monica Bulla, Paula Nunes, Fabrice Antigny, Anna Marchetti, Nicolas Demaurex
Publikováno v:
Journal of Cell Science
Journal of cell science
J Cell Sci
Journal of Cell Science, Vol. 128, No 8 (2015) pp. 1568-79
Journal of cell science
J Cell Sci
Journal of Cell Science, Vol. 128, No 8 (2015) pp. 1568-79
STIM proteins populate and expand cortical endoplasmic reticulum (ER) sheets to mediate store-operated Ca(2+) entry (SOCE) by trapping and gating Orai channels in ER-plasma membrane clusters. A longer splice variant, STIM1L, forms permanent ER-plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af39f0b8838a54d93f117c954a0ad178
https://doi.org/10.1242/jcs.164228
https://doi.org/10.1242/jcs.164228