Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Leland Otto Weigel"'
Autor:
Justin C. Smith, Samuel Dean Larsen, Leland Otto Weigel, Jeffrey A. Ward, Ryan J. Linder, Susan M. Reutzel-Edens, Perry Clark Heath, Stanley P. Kolis, Marvin M. Hansen, Marcella T. Clayton, Sandra S. K. Borders, Shella Lenyonga Tameze
Publikováno v:
Organic Process Research & Development. 13:198-208
An efficient and scalable synthesis of the clinical candidate 1 is described. The first-generation synthesis built the enantioenriched nitro-aminoindanol core from 6-nitroindanone using a five-step literature route. The second-generation route used a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::228e4c59294cf55a0c3b7b98aba7b55d
https://doi.org/10.1021/op800243q
https://doi.org/10.1021/op800243q
Autor:
Richard Lowe, Charles Q. Huang, Jeffery P. Whitten, Leland Otto Weigel, Perry Clark Heath, Mccarthy James R
Publikováno v:
Tetrahedron Letters. 42:1607-1610
Acylation of 1,3-disubstituted thioureas with methyl malonyl chloride followed by base-catalyzed cyclization leads to the preparation of 1,3-disubstituted-2-thiobarbituric acids in high yield.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::501478b5a2d5b2bf2a21da2c337db8e5
https://doi.org/10.1016/s0040-4039(01)00011-9
https://doi.org/10.1016/s0040-4039(01)00011-9
Publikováno v:
Tetrahedron Letters. 40:2239-2242
A five step synthesis of thiotomoxetine ( 2 ) is described. Installation of the aryl ether was accomplished using a highly efficient S N Ar fragment coupling between amino alcohol ( 4 ) and a 1-halo-2-methylsulfinylbenzene (X = F or Cl) followed by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edea01d2baa6ee398e9340ee5a6c65ac
https://doi.org/10.1016/s0040-4039(99)00215-4
https://doi.org/10.1016/s0040-4039(99)00215-4
Autor:
J. J. Droste, Perry Clark Heath, Harry A. Kay, Richard D. Miller, Leland Otto Weigel, James E. Audia, Jill H. Eifert, Dale W. Holme, J. M. Dunigan, Thomas F. Rainey, John L Bowers, Jorge M. Olivares
Publikováno v:
Tetrahedron Letters. 37:4121-4124
In one operation, metalloenamines derived from R -phenylethylamine (PEA) and a β-tetralone were treated with an electrophile followed by acrylic anhydride. The unpurified lactams were reduced to give 10b-angular benzoquinolinones (BQs).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fad9d0eed5daa7685ad83d270a0c2ec6
https://doi.org/10.1016/0040-4039(96)00724-1
https://doi.org/10.1016/0040-4039(96)00724-1
Autor:
James P. Wepsiec, Leland Otto Weigel, Bret A. Astleford, Kress Thomas Joseph, Jack B. Deeter, Perry Clark Heath, Samantha K. Janisse, James E. Audia
Publikováno v:
The Journal of Organic Chemistry. 61:4450-4454
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a194250d5079ccfd571f9e6bd420774a
https://doi.org/10.1021/jo9601425
https://doi.org/10.1021/jo9601425
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14aea7a0bf9ee7bb06b3409bb2059d29
https://doi.org/10.1002/chin.199238265
https://doi.org/10.1002/chin.199238265
Autor:
Leland Otto Weigel, Joseph A. Turpin
Publikováno v:
ChemInform. 24
Sharpless asymmetric dihydroxylation (AD) of 6-hepten-2-one with AD-mix-α® followed by acidification gives (1S,SR)-5-methyl- 6,8-dioxabicyclo[3.2.1]octane in moderate ee. This methodology defines a two-pot enantioselective construction of the (−)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1da38548ff407a2a73387e06f7f2265
https://doi.org/10.1002/chin.199312269
https://doi.org/10.1002/chin.199312269
Autor:
Richard D. Miller, J. M. Dunigan, Jill H. Eifert, John L Bowers, Thomas F. Rainey, Perry Clark Heath, J. J. Droste, Harry A. Kay, Jorge M. Olivares, Dale W. Holme, Leland Otto Weigel, James E. Audia
Publikováno v:
ChemInform. 27
In one operation, metalloenamines derived from R -phenylethylamine (PEA) and a β-tetralone were treated with an electrophile followed by acrylic anhydride. The unpurified lactams were reduced to give 10b-angular benzoquinolinones (BQs).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e64d1d6edf94487e0bf91496cf0a4965
https://doi.org/10.1002/chin.199637206
https://doi.org/10.1002/chin.199637206
Autor:
James E. Audia, Jack B. Deeter, Leland Otto Weigel, James P. Wepsiec, Kress Thomas Joseph, Bret A. Astleford, S. K. Janisse, Perry Clark Heath
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53e0bbf1a59add267a8732c8137ccc11
https://doi.org/10.1002/chin.199645052
https://doi.org/10.1002/chin.199645052
Publikováno v:
ChemInform. 30
A five step synthesis of thiotomoxetine ( 2 ) is described. Installation of the aryl ether was accomplished using a highly efficient S N Ar fragment coupling between amino alcohol ( 4 ) and a 1-halo-2-methylsulfinylbenzene (X = F or Cl) followed by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e0297d7be64e3bf6a5f4a5fc209d85f
https://doi.org/10.1002/chin.199923119
https://doi.org/10.1002/chin.199923119