Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Leland Mayne"'
Publikováno v:
eLife, Vol 13 (2024)
The physical basis of phase separation is thought to consist of the same types of bonds that specify conventional macromolecular interactions yet is unsatisfyingly often referred to as ‘fuzzy’. Gaining clarity on the biogenesis of membraneless ce
Externí odkaz:
https://doaj.org/article/bb7584e87cb0404fabab508905f3d31e
Autor:
Palaniappan Sevugan Chetty, David Nguyen, Margaret Nickel, Sissel Lund-Katz, Leland Mayne, S.Walter Englander, Michael C. Phillips
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 6, Pp 1589-1597 (2013)
Elucidation of apoA-I secondary structure in spherical plasma HDL particles is essential for understanding HDL structure and function at the molecular level. To provide this information, we have applied hydrogen exchange (HX) and mass spectrometry me
Externí odkaz:
https://doaj.org/article/c1819ae8aeb2452eb464c7ad4db5c4b1
Publikováno v:
bioRxiv
The physical basis of phase separation is thought to consist of the same types of bonds that specify conventional macromolecular interactions yet is unsatisfyingly often referred to as ‘fuzzy’. Gaining clarity on the biogenesis of membraneless ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b7a7b38837d4acf648c620492372a6
https://europepmc.org/articles/PMC10245869/
https://europepmc.org/articles/PMC10245869/
Publikováno v:
Blood.
Antibody binding to a plasma metalloprotease ADAMTS13 is necessary for the development of immune thrombotic thrombocytopenic purpura (iTTP). Inhibition of ADAMTS13-mediated VWF cleavage by such antibodies clearly plays a role in the pathophysiology o
Publikováno v:
Proc Natl Acad Sci U S A
Hsp104 provides a valuable model for the many essential proteostatic functions performed by the AAA+ superfamily of protein molecular machines. We developed and used a powerful hydrogen exchange mass spectrometry (HX MS) analysis that can provide pos
Publikováno v:
Analytical Chemistry. 91:7474-7481
Hydrogen-deuterium exchange mass spectrometry (HDX MS) has become an important technique for the analysis of protein structure and dynamics. Data analysis remains a bottleneck in the workflow. Sophisticated computer analysis is required to scan throu
Autor:
Cecilia Vitali, Sumeet A. Khetarpal, Daniel J. Rader, John S. Millar, Sissel Lund-Katz, S. Walter Englander, Sylvia Stankov, Nicholas J. Hand, Michael C. Phillips, Leland Mayne
In humans, apolipoprotein C-III (apoC-III) plasma levels have been associated with increased risk of cardiovascular disease. This association is in part explained by the effects of apoC-III on triglyceride (TG) metabolism; apoC-III raises plasma TG b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a500570d2f526eaf1ccbd1d3815d4b7c
https://doi.org/10.1101/2020.07.02.183178
https://doi.org/10.1101/2020.07.02.183178
Autor:
Dewey G. McCafferty, Leland Mayne, A. Katherine Hatstat, M. Arthur Moseley, S. Walter Englander, Matthew W. Foster, Hannah D. Ahrendt
Publikováno v:
Cell Chem Biol
SummaryThe benzdiimidazole NAB2 rescues α-synuclein-associated trafficking defects associated with early onset Parkinson’s disease in a Nedd4-dependent manner. Despite identification of E3 ubiquitin ligase Nedd4 as a putative target of NAB2, its m
Publikováno v:
Journal of the American Society for Mass Spectrometry. 29:1936-1939
The analysis of many hydrogen exchange (HX) experiments depends on knowledge of exchange rates expected for the unstructured protein under the same conditions. We present here some minor adjustments to previously calibrated values and a stringent tes
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The GroEL/ES chaperonin is known to prevent protein aggregation during folding by passive containment within the central cavity. The possible role of more active intervention is controversial. The HX MS method documents an organized hydr