Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Leland Ellis"'
Publikováno v:
Bioinformatics. 16:1003-1009
This paper examines a new technique for the visualization of and the interaction with trees, objects frequently used to convey hierarchical relationships in biological data. Motivated by the quality of 2D tree interaction, we adapt the planar tree-of
Publikováno v:
Journal of Biological Chemistry. 270:8122-8130
The deduced primary sequence of the cytoplasmic protein-tyrosine kinase domain of the insulin receptor contains a conserved kinase homology region (receptor residues 1002-1257) flanked by a juxtamembrane region and a C-terminal tail. A soluble 48-kDa
Publikováno v:
Current Opinion in Structural Biology. 4:450-455
The elucidation of the three-dimensional structures of complexes of the catalytic subunit of mouse recombinant CAMP-dependent protein kinase with bound divalent ion, nucleotide and peptide inhibitor provides new insights into the structural organizat
Autor:
Valérie Viard, Shanna D. Maika, Purita Ramos, Joëlle Morin, Luc Pénicaud, Leland Ellis, Erik Schaefer, Robert E. Hammer, Pascal Ferré
Publikováno v:
Diabetes. 43:143-153
Expression under the control of the mouse transferrin promoter of a transgene encoding a soluble secreted derivative of the ectodomain of the human insulin receptor in transgenic mice results in the accumulation of this high-affinity insulin-binding
Autor:
Jane A. Madden, Philip A. Gruppuso, David L. Brautigan, Leland Ellis, Thomas Raven, Joan M. Boylan
Publikováno v:
Journal of Clinical Investigation. 90:174-179
The involvement of tyrosine phosphorylation in insulin action led us to hypothesize that increased activity of protein tyrosine phosphatases (PTPases) might contribute to insulin resistance in alloxan diabetes in the rat. Hepatic PTPase activity was
Autor:
Erik Schaefer, Falk Fahrenholz, Elzbieta Kojro, Dietrich Brandenburg, Leland Ellis, Marlies Fabry
Publikováno v:
Journal of Biological Chemistry. 267:8950-8956
We have used a preparation of soluble human insulin receptor ectodomain and a novel photoreactive, biotinylated derivative of insulin (4-azidosalicyloyl(B1-biocytinyl-B2-lysine)-insulin) to identify a new hormone contact site within the extracellular
Publikováno v:
Biochemical Society Transactions. 19:426-432
Six years have now elapsed since efforts to establish heterologous cell expression systems for studies of the human insulin receptor were begun. As is apparent from the results summarized in Figs. 1 and 2, a significant number of studies have been de
Publikováno v:
Proceedings of the National Academy of Sciences. 88:877-881
A previous study showed that the human insulin receptor (IR) could be activated by insertion of a 3' portion of the cDNA encoding the beta subunit into a retrovirus genome to form a Gag-IR fusion protein. While capable of transforming cells in cultur
Publikováno v:
Biochemical and Biophysical Research Communications. 174:772-778
To investigate the mechanism of tyrosine phosphorylation by the insulin receptor protein-tyrosine kinase, we utilized a synthetic dodecapeptide substrate (RRDIYETDYYRK; amino acids 1155-1165) containing the three major insulin receptor autophosphoryl
Publikováno v:
Developmental Brain Research. 56:131-136
Growth cone particle (GCP) membranes prepared from fetal day 17 rat brain are comprised of 5 major polypeptides as analyzed by SDS-PAGE: tubulin (p52), actin (p42), pp46/GAP-43 and two unidentified species, p38 and p3414,46,52. Antibodies specific fo