Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Leland D. Powell"'
Publikováno v:
Blood. 136:27-28
Introduction: Idiopathic multicentric Castleman disease (iMCD) is a heterogenous group of lymphoproliferative disorders believed to be driven by IL-6 with the cell(s) of origin not yet identified (Fajgenbaum et al. 2019). One clinical subtype with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ad8121778ea64bd2f7ec41bc7fd2623
https://doi.org/10.1182/blood-2020-137338
https://doi.org/10.1182/blood-2020-137338
Autor:
Shirley Reynolds, Takashi Angata, Els C. M. Brinkman-Van der Linden, Stephen M. Hedrick, Leland D. Powell, Ajit Varki
Publikováno v:
Molecular and Cellular Biology. 23:4199-4206
Mouse CD33/Siglec-3 (mCD33) is the apparent ortholog of human CD33/Siglec-3 (hCD33), a member of the Siglec (sialic acid-binding Ig superfamily lectin) family of sialic acid-recognizing cell-surface lectins. We examined the binding specificity and ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a7a3463285cc8e6f94172710c53951
https://doi.org/10.1128/mcb.23.12.4199-4206.2003
https://doi.org/10.1128/mcb.23.12.4199-4206.2003
Publikováno v:
Journal of Biological Chemistry. 270:7543-7550
CD22 is a cell-surface receptor of resting mature B cells that recognizes sialic acid (Sia) in the natural structure Sia alpha 2-6Gal beta 1-4GlcNAc (Powell, L. D., Jain, R. K., Matta, K. L., Sabesan, S., and Varki, A. (1995) J. Biol. Chem. 270, 7523
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2cb3a5eb971314eecd73e1603dd9f54
https://doi.org/10.1074/jbc.270.13.7543
https://doi.org/10.1074/jbc.270.13.7543
Publikováno v:
Journal of Biological Chemistry. 270:7533-7542
We previously showed that cultured human umbilical vein endothelial cells (HEC) exposed to the inflammatory cytokines tumor necrosis factor-alpha or interleukin-1 display increased activity of beta-galactoside alpha 2,6-sialyltransferase. This is ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ab5a71a4f2fb9c3a17b659524d5640d
https://doi.org/10.1074/jbc.270.13.7533
https://doi.org/10.1074/jbc.270.13.7533
Publikováno v:
Journal of Biological Chemistry. 270:7523-7532
CD22, a B cell-specific receptor of the immunoglobulin superfamily, has been demonstrated to bind to oligosaccharides containing α2-6-linked sialic acid (Sia) residues. Previously, we demonstrated that the minimal structure recognized by this lectin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69a3d8c470987836896fa76e2b134b59
https://doi.org/10.1074/jbc.270.13.7523
https://doi.org/10.1074/jbc.270.13.7523
Publikováno v:
The Journal of Cell Biology
CD22 beta is a B cell-restricted phosphoprotein expressed on the surface of mature resting B cells. It mediates interactions with other cells partly or exclusively via recognition of alpha 2-6-linked sialic acids on glycoconjugates. The sialylated N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2928e00b90a428c7c668200cf9954d15
https://doi.org/10.1083/jcb.126.2.549
https://doi.org/10.1083/jcb.126.2.549
Autor:
Ajit Varki, Leland D. Powell
Publikováno v:
Journal of Biological Chemistry. 269:10628-10636
CD22 beta is a B cell surface glycoprotein involved in cell adhesion and activation. We previously reported that a recombinant soluble form termed CD22 beta Rg is capable of binding alpha 2-6 sialylated complex N-linked oligosaccharides purified from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::026861e3944c8eb36bedf5250275d156
https://doi.org/10.1016/s0021-9258(17)34106-6
https://doi.org/10.1016/s0021-9258(17)34106-6
Publikováno v:
Current Protocols in Immunology
Glycosidases are specific enzymes that can partially or completely remove sugar chains from cell-surface glycoconjugates. The enzymes can be exoglycosidases (which remove a terminal saccharide unit from an oligosaccharide chain), endoglycosidases (wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768807ca7298cc8dc7fffb1b7bc5e12f
https://pubmed.ncbi.nlm.nih.gov/18432855
https://pubmed.ncbi.nlm.nih.gov/18432855
Autor:
Leland D. Powell, Ajit Varki
Publikováno v:
Current protocols in molecular biology.
Sialic acids are a family of nine-carbon acidic sugars found at the nonreducing terminus of many glycoconjugates. Sialidases can remove these sugar units selectively from cell surfaces, membranes, or purified glycoconjugates. In this unit, sialidase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd05908c6ea7f4643a01bef3f5db0a81
https://pubmed.ncbi.nlm.nih.gov/18265140
https://pubmed.ncbi.nlm.nih.gov/18265140
Publikováno v:
Current Protocols in Molecular Biology
This unit presents methods for assaying sialic acids, reducing sugars, and hexosamines. The BCA assay detects free reducing terminii in sugars released from glycoconjugates by appropriate treatments. Assays employing Ehrlich reagent (DMAB) detect hex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb5323d566de6ba46788887682876a7
https://pubmed.ncbi.nlm.nih.gov/18265150
https://pubmed.ncbi.nlm.nih.gov/18265150