Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Lela, Lackey"'
Autor:
Jayashree Kumar, Lela Lackey, Justin M Waldern, Abhishek Dey, Anthony M Mustoe, Kevin M Weeks, David H Mathews, Alain Laederach
Publikováno v:
eLife, Vol 11 (2022)
Splicing is highly regulated and is modulated by numerous factors. Quantitative predictions for how a mutation will affect precursor mRNA (pre-mRNA) structure and downstream function are particularly challenging. Here, we use a novel chemical probing
Externí odkaz:
https://doaj.org/article/7e9b5b2f330645718e814d97ac9b25a0
Autor:
Lela Lackey, Aaztli Coria, Auyon J Ghosh, Phil Grayeski, Abigail Hatfield, Vijay Shankar, John Platig, Zhonghui Xu, Silvia B V Ramos, Edwin K Silverman, Victor E Ortega, Michael H Cho, Craig P Hersh, Brian D Hobbs, Peter Castaldi, Alain Laederach
Publikováno v:
PLoS Genetics, Vol 17, Iss 11, p e1009912 (2021)
α1-anti-trypsin (A1AT), encoded by SERPINA1, is a neutrophil elastase inhibitor that controls the inflammatory response in the lung. Severe A1AT deficiency increases risk for Chronic Obstructive Pulmonary Disease (COPD), however, the role of A1AT in
Externí odkaz:
https://doaj.org/article/a9364620e0274197ae0b0ec2bcff504b
Autor:
Philip J Grayeski, Chase A Weidmann, Jayashree Kumar, Lela Lackey, Anthony M Mustoe, Steven Busan, Alain Laederach, Kevin M Weeks
Publikováno v:
Nucleic Acids Research. 50:9689-9704
SERPINA1 mRNAs encode the protease inhibitor α-1-antitrypsin and are regulated through post-transcriptional mechanisms. α-1-antitrypsin deficiency leads to chronic obstructive pulmonary disease (COPD) and liver cirrhosis, and specific variants in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb810ff2966ba613603ad6a2c8b20be
https://doi.org/10.1093/nar/gkac739
https://doi.org/10.1093/nar/gkac739
Publikováno v:
Bioscience Reports. 43
RNA is a fundamental biomolecule that has many purposes within cells. Due to its single-stranded and flexible nature, RNA naturally folds into complex and dynamic structures. Recent technological and computational advances have produced an explosion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d4f4f8d127738cd2ba9bc7c7fd56800
https://doi.org/10.1042/bsr20220149
https://doi.org/10.1042/bsr20220149
Autor:
William L. Brown, Emily K. Law, Prokopios P. Argyris, Michael A. Carpenter, Rena Levin-Klein, Alison N. Ranum, Amy M. Molan, Colleen L. Forster, Brett D. Anderson, Lela Lackey, Reuben S. Harris
Publikováno v:
Antibodies, Vol 8, Iss 3, p 47 (2019)
The DNA cytosine deaminase APOBEC3B (A3B) is normally an antiviral factor in the innate immune response. However, A3B has been implicated in cancer mutagenesis, particularly in solid tumors of the bladder, breast, cervix, head/neck, and lung. Here, w
Externí odkaz:
https://doaj.org/article/9c5c56eb7a114604a751bbb5fa5726cc
Autor:
Victor E. Ortega, Xingnan Li, Wanda K. O’Neal, Lela Lackey, Elizabeth Ampleford, Gregory A. Hawkins, Philip J. Grayeski, Alain Laederach, Igor Barjaktarevic, R. Graham Barr, Christopher Cooper, David Couper, MeiLan K. Han, Richard E. Kanner, Eric C. Kleerup, Fernando J. Martinez, Robert Paine, Stephen P. Peters, Cheryl Pirozzi, Stephen I. Rennard, Prescott G. Woodruff, Eric A. Hoffman, Deborah A. Meyers, Eugene R. Bleecker, Neil E. Alexis, Wayne H. Anderson, Mehrdad Arjomandi, Lori A. Bateman, Surya P. Bhatt, Richard C. Boucher, Russell P. Bowler, Stephanie A. Christenson, Alejandro P. Comellas, Gerard J. Criner, Ronald G. Crystal, Jeffrey L. Curtis, Claire M. Doerschuk, Mark T. Dransfield, Christine M. Freeman, Craig Galban, Nadia N. Hansel, Annette T. Hastie, Yvonne Huang, Robert J. Kaner, Jerry A. Krishnan, Lisa M. LaVange, Stephen C. Lazarus, Wendy C. Moore, Laura Paulin, Nirupama Putcha, Elizabeth C. Oelsner, Sanjeev Raman, Donald P. Tashkin, J. Michael Wells, Robert A. Wise
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 201:540-554
Rationale: The role of PI (protease inhibitor) type Z heterozygotes and additional rare variant genotypes in the gene encoding alpha-1 antitrypsin, SERPINA1 (serpin peptidase inhibitor, clade A, me...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19531e765c6ee6b07e05aa3f38151efa
https://doi.org/10.1164/rccm.201904-0769oc
https://doi.org/10.1164/rccm.201904-0769oc
Autor:
Edwin K. Silverman, Phil Grayeski, Brian D. Hobbs, Craig P. Hersh, Peter J. Castaldi, Aaztli Coria, Silvia B. V. Ramos, Zhonghui Xu, Victor E Ortega, Michael H. Cho, Lela Lackey, Alain Laederach, John Platig, Vijay Shankar, Auyon J. Ghosh, Luke Hatfield
Publikováno v:
PLoS Genetics, Vol 17, Iss 11, p e1009912 (2021)
PLoS Genetics
PLoS Genetics
α1-anti-trypsin (A1AT), encoded by SERPINA1, is a neutrophil elastase inhibitor that controls the inflammatory response in the lung. Severe A1AT deficiency increases risk for Chronic Obstructive Pulmonary Disease (COPD), however, the role of A1AT in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420550d518a8c155729cb937a1a95399
https://doaj.org/article/a9364620e0274197ae0b0ec2bcff504b
https://doaj.org/article/a9364620e0274197ae0b0ec2bcff504b
Autor:
Jayashree, Kumar, Lela, Lackey, Justin M, Waldern, Abhishek, Dey, Anthony M, Mustoe, Kevin M, Weeks, David H, Mathews, Alain, Laederach
Publikováno v:
eLife. 11
Splicing is highly regulated and is modulated by numerous factors. Quantitative predictions for how a mutation will affect precursor mRNA (pre-mRNA) structure and downstream function are particularly challenging. Here, we use a novel chemical probing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6fc7c50a9184214a8a0540edd39de861
https://pubmed.ncbi.nlm.nih.gov/35695373
https://pubmed.ncbi.nlm.nih.gov/35695373
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140885 (2015)
Genome-wide association studies aim to correlate genotype with phenotype. Many common diseases including Type II diabetes, Alzheimer's, Parkinson's and Chronic Obstructive Pulmonary Disease (COPD) are complex genetic traits with hundreds of different
Externí odkaz:
https://doaj.org/article/95550644295844d2b30f4d0077874646