Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Lekun Fang"'
Autor:
Shaomin Zou, Chao Yang, Jieping Zhang, Dan Zhong, Manqi Meng, Lu Zhang, Honglei Chen, Lekun Fang
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Colorectal cancer (CRC) is the leading cancer worldwide. Microbial agents have been considered to contribute to the pathogenesis of different disease. But the underlying relevance between CRC and microbiota remain unclear. Methods
Externí odkaz:
https://doaj.org/article/d77416357b9248e7a89cba683d9e0967
Autor:
Shaomin Zou, Yizhi Huang, Ziqing Yang, Jieping Zhang, Manqi Meng, Yijing Zhang, Junyan Feng, Rui Sun, Weiyao Li, Wencong Wang, Jesús García‐Foncillas López, Lekun Fang
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 3, Pp n/a-n/a (2024)
Abstract Background NOP2/Sun domain 2 (NSUN2) is one of the important RNA methyltransferases catalyzing 5‐methylcytosine (m5C) formation and participates in many critical bioprocesses. However, the roles and underlying molecular mechanisms of NSUN2
Externí odkaz:
https://doaj.org/article/26e23d0b2dc04d99b082fbce6001a3e9
Autor:
Chunsik Lee, Rongyuan Chen, Guangli Sun, Xialin Liu, Xianchai Lin, Chang He, Liying Xing, Lixian Liu, Lasse D. Jensen, Anil Kumar, Harald F. Langer, Xiangrong Ren, Jianing Zhang, Lijuan Huang, Xiangke Yin, JongKyong Kim, Juanhua Zhu, Guanqun Huang, Jiani Li, Weiwei Lu, Wei Chen, Juanxi Liu, Jiaxin Hu, Qihang Sun, Weisi Lu, Lekun Fang, Shasha Wang, Haiqing Kuang, Yihan Zhang, Geng Tian, Jia Mi, Bi-Ang Kang, Masashi Narazaki, Aaron Prodeus, Luc Schoonjans, David M. Ornitz, Jean Gariepy, Guy Eelen, Mieke Dewerchin, Yunlong Yang, Jing-Song Ou, Antonio Mora, Jin Yao, Chen Zhao, Yizhi Liu, Peter Carmeliet, Yihai Cao, Xuri Li
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract Although VEGF-B was discovered as a VEGF-A homolog a long time ago, the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups. Notwithstanding, drugs that inhibit VEGF-B together with o
Externí odkaz:
https://doaj.org/article/ad0f2de2f96d45acbb44f158c21c99b6
Autor:
Ziqing Yang, Shaomin Zou, Yijing Zhang, Jieping Zhang, Peng Zhang, Lishi Xiao, Yunling Xie, Manqi Meng, Junyan Feng, Liang Kang, Mong-Hong Lee, Lekun Fang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Gastric cancer (GC), one of the most common malignant tumors in the world, exhibits a rapid metastasis rate and causes high mortality. Diagnostic markers and potential therapeutic targets for GCs are urgently needed. Here we show that Actin-
Externí odkaz:
https://doaj.org/article/4662bfd294c7433087d0c103687e79ff
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-21 (2023)
Abstract With high prevalence and mortality, together with metabolic reprogramming, colorectal cancer is a leading cause of cancer-related death. Metabolic reprogramming gives tumors the capacity for long-term cell proliferation, making it a distingu
Externí odkaz:
https://doaj.org/article/2e8af8c80ee34812a8afed0827d79974
Autor:
Ziqing Yang, Dandan Huang, Manqi Meng, Wencong Wang, Junyan Feng, Lekun Fang, Honglei Chen, Shaomin Zou
Publikováno v:
Cell Death and Disease, Vol 13, Iss 12, Pp 1-10 (2022)
Abstract BAF53A, an important subunit of the SWI/SNF epigenetic chromatin regulatory complex, has been implicated as the driver of diverse cancers. However, the role of BAF53A in colorectal cancer (CRC) remains poorly understood. Here, we examined th
Externí odkaz:
https://doaj.org/article/08ec599cc63749619f99d7d45eef0584
Autor:
Yanjiong He, Zuolin Zhou, Xiaoyan Huang, Qi Guan, Qiyuan Qin, Miaomiao Zhu, Huaiming Wang, Qinghua Zhong, Daici Chen, Hui Wang, Lekun Fang, Tenghui Ma
Publikováno v:
Frontiers in Surgery, Vol 9 (2022)
BackgroundChronic radiation proctopathy (CRP) is a common complication after radiation therapy for pelvic malignancies. Compared with diversion surgery, resection surgery removes the damaged tissue completely to avoid the risks of recurrence and impr
Externí odkaz:
https://doaj.org/article/3aab6f00ac8f47da871defdb9f697fd0
Autor:
Jieping Zhang, Shaomin Zou, Yijing Zhang, Ziqing Yang, Wencong Wang, Manqi Meng, Junyan Feng, Peng Zhang, Lishi Xiao, Mong-Hong Lee, Lekun Fang
Publikováno v:
Metabolites, Vol 12, Iss 5, p 410 (2022)
Chemoresistance limits treatment outcomes in colorectal cancer (CRC) patients. A dimeric metabolite of indole-3-carbinol, 3,3′-diindolylmethane (DIM) is abundant in cruciferous vegetables and has shown anticancer efficacy. The role of DIM in regula
Externí odkaz:
https://doaj.org/article/cca914e65b3841358e935daca3dcaabf
Autor:
Hyun Ho Choi, Shaomin Zou, Jian‐lin Wu, Huashe Wang, Liem Phan, Kai Li, Peng Zhang, Daici Chen, Qingxin Liu, Baifu Qin, Thu Anh Thai Nguyen, Sai‐Ching J. Yeung, Lekun Fang, Mong‐Hong Lee
Publikováno v:
Advanced Science, Vol 7, Iss 20, Pp n/a-n/a (2020)
Abstract Forkhead‐Box Class O 4 (FOXO4) is involved in critical biological functions, but its response to EGF‐PKB/Akt signal regulation is not well characterized. Here, it is reported that FOXO4 levels are downregulated in response to EGF treatme
Externí odkaz:
https://doaj.org/article/07e2461fc3204a8caf3e26bf7403d47c
Autor:
Mong-Hong Lee, Jianping Wang, Puning Wang, Yanhong Deng, Lei Wang, Chwan-Deng Hsiao, Jung-Yu Tung, Junyi Zhou, Zihuan Yang, Lekun Fang
Biomarkers for predicting chemotherapy response are important to the treatment of colorectal cancer patients. Cryptochrome 2 (CRY2) is a circadian clock protein involved in cell cycle, but the biologic consequences of this activity in cancer are poor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17dd11b54f9f0affe4fb34b3e2d9eb75
https://doi.org/10.1158/1535-7163.c.6536463.v1
https://doi.org/10.1158/1535-7163.c.6536463.v1
