Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lekshmy Sreekumar"'
Autor:
Yan Ting Lim, Nayana Prabhu, Lingyun Dai, Ka Diam Go, Dan Chen, Lekshmy Sreekumar, Louise Egeblad, Staffan Eriksson, Liyan Chen, Saranya Veerappan, Hsiang Ling Teo, Chris Soon Heng Tan, Johan Lengqvist, Andreas Larsson, Radoslaw M Sobota, Pär Nordlund
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208273 (2018)
Metabolite-protein interactions define the output of metabolic pathways and regulate many cellular processes. Although diseases are often characterized by distortions in metabolic processes, efficient means to discover and study such interactions dir
Externí odkaz:
https://doaj.org/article/dcb759615b25496c939a0c9fb00a7898
Autor:
Anderson Daniel Ramos, Takahiro Seki, Yihai Cao, Nayana Prabhu, Pär Nordlund, Smaranda Bacanu, Lekshmy Sreekumar, Lingyun Dai, Ying Yu Liang, David P. Lane, Cynthia R. Coffill, Jindrich Cinatl, Martin Michaelis
Publikováno v:
Cell Chemical Biology. 29:572-585.e8
The optimal use of many cancer drugs is hampered by a lack of detailed understanding of their mechanism of action (MoA). Here, we apply a high-resolution implementation of the proteome-wide cellular thermal shift assay (CETSA) to follow protein inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d7f2017ded42f03ce2637176027e34
https://doi.org/10.1016/j.chembiol.2021.06.007
https://doi.org/10.1016/j.chembiol.2021.06.007
Autor:
Xavier Bisteau, Nayana Prabhu, Radoslaw M. Sobota, Pär Nordlund, Johan Lengqvist, Vinay Tergaonkar, Lingyun Dai, Yan Ting Lim, Lekshmy Sreekumar, Chern Han Yong, Philipp Kaldis, Chris Soon Heng Tan, Ka Diam Go, Mert Burak Ozturk
Publikováno v:
Science, 359 (6380
Proteins differentially interact with each other across cellular states and conditions, but an efficient proteome-wide strategy to monitor them is lacking. We report the application of thermal proximity coaggregation (TPCA) for high-throughput intrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286bb3fc6116b23f68d95095bfde77d8
http://hdl.handle.net/10220/48481
http://hdl.handle.net/10220/48481
Autor:
Dan Chen, Staffan Eriksson, Nayana Prabhu, Lekshmy Sreekumar, Yan Ting Lim, Louise Egeblad, Chris Soon Heng Tan, Liyan Chen, Saranya Veerappan, Johan Lengqvist, Radoslaw M. Sobota, Pär Nordlund, Ka Diam Go, Lingyun Dai, Andreas Larsson, Hsiangling Teo
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208273 (2018)
PLoS ONE
PLoS ONE
Metabolite-protein interactions define the output of metabolic pathways and regulate many cellular processes. Although diseases are often characterized by distortions in metabolic processes, efficient means to discover and study such interactions dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f3ec76fec030f3c51f1c5712d2b19e
https://doi.org/10.1371/journal.pone.0208273
https://doi.org/10.1371/journal.pone.0208273
Autor:
Pär Nordlund, Chen Dan, Daniel Martinez Molina, Marina Ignatushchenko, Yihai Cao, Lekshmy Sreekumar, Takahiro Seki, Rozbeh Jafari, E. Andreas Larsson
Publikováno v:
Science. 341:84-87
Drug Targeting Drug efficacy depends on the extent of binding to a cellular target (often a protein) with adverse effects caused by excessive target binding or by off-target binding. Engagement of a target protein inside cells is influenced by the ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d563eee3ab63be84bb2e6eef2b5ef3
https://doi.org/10.1126/science.1233606
https://doi.org/10.1126/science.1233606
Publikováno v:
Cancer Research. 77:2045-2045
The aim of this project is to understand the various mechanisms contributing to drug resistance development in cancer therapy. The efficacy of therapeutics is dependent on a drug binding to its target. We have developed a method that allows for the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::954a4672a8d92eee34bd5ff571969079
https://doi.org/10.1158/1538-7445.am2017-2045
https://doi.org/10.1158/1538-7445.am2017-2045
Autor:
Johan Lengqvist, Anna Elisabet Jansson, Andreas Larsson, Nayana Prabhu, Rozbeh Jafari, Pär Nordlund, Sara Lööf, Anette Öberg, Yan Ting Lim, Radoslaw M. Sobota, Lingyun Dai, Henritte Laursen, Daniel Martines Molina, Lekshmy Sreekumar, Ka Diam Go, Chris Heng Tan Soon
Publikováno v:
Cancer Research. 76:4386-4386
A key step of the action of most drugs is their binding (engagement) of the target protein(s). However, limitations in the available methods for directly accessing this critical step have added uncertainties in many stages of drug development. We hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5d0299c2e5fa6340b9d07bfcec1247a
https://doi.org/10.1158/1538-7445.am2016-4386
https://doi.org/10.1158/1538-7445.am2016-4386