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Regulation of STAT1 Signaling in Human Pancreatic β-Cells by the Lysine Deacetylase HDAC6: A New Therapeutic Opportunity in Type 1 Diabetes?

Autor: Leslie, Kaiyven Afi, Lekka, Christiana, Richardson, Sarah J., Russell, Mark A., Morgan, Noel G.

Publikováno v: Diabetes; Sep2024, Vol. 73 Issue 9, p1473-1485, 13p

Interferon-α promotes neo-antigen formation and preferential HLA-B-restricted antigen presentation in pancreatic β-cells.

Autor: Carré A; Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France., Zhou Z; Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France., Perez-Hernandez J; Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.; Department of Nutrition and Health, Valencian International University (VIU), Valencia, Spain., Samassa F; Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France., Lekka C; Islet Biology Group, Exeter Centre of Excellence in Diabetes Research, University of Exeter Medical School, Exeter, UK., Manganaro A; Diabetes Center of Excellence, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Oshima M; Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France., Liao H; Centre for Immuno-Oncology, Nuffield Department of Medicine, University of Oxford, UK., Parker R; Centre for Immuno-Oncology, Nuffield Department of Medicine, University of Oxford, UK., Nicastri A; Centre for Immuno-Oncology, Nuffield Department of Medicine, University of Oxford, UK., Brandao B; Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France., Colli ML; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium., Eizirik DL; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium., Göransson M; Department of Health Technology, Technical University of Denmark, Copenhagen, Denmark., Morales OB; Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France., Anderson A; Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO, USA., Landry L; Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO, USA., Kobaisi F; Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France., Scharfmann R; Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France., Marselli L; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Marchetti P; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., You S; Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.; Indiana Biosciences Research Institute, Indianapolis, IN, USA., Nakayama M; Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO, USA., Hadrup SR; Department of Health Technology, Technical University of Denmark, Copenhagen, Denmark., Kent SC; Diabetes Center of Excellence, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Richardson SJ; Islet Biology Group, Exeter Centre of Excellence in Diabetes Research, University of Exeter Medical School, Exeter, UK., Ternette N; Centre for Immuno-Oncology, Nuffield Department of Medicine, University of Oxford, UK., Mallone R; Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.; Indiana Biosciences Research Institute, Indianapolis, IN, USA.; Assistance Publique Hôpitaux de Paris, Service de Diabétologie et Immunologie Clinique, Cochin Hospital, Paris, France.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 17. Date of Electronic Publication: 2023 Sep 17.