Compassionate access to virus-specific T cells for adoptive immunotherapy over 15 years

Autor: Michelle A. Neller, George R. Ambalathingal, Nada Hamad, Joe Sasadeusz, Rebecca Pearson, Chien-Li Holmes-Liew, Deepak Singhal, Matthew Tunbridge, Wei Yang Ng, Kirsty Sharplin, Andrew Moore, David Deambrosis, Trisha Soosay-Raj, Peter McNaughton, Morag Whyte, Chris Fraser, Andrew Grigg, David Kliman, Ashish Bajel, Katherine Cummins, Mark Dowling, Zhi Han Yeoh, Simon J. Harrison, Amit Khot, Sarah Tan, Izanne Roos, Ray Mun Koo, Sara Dohrmann, David Ritchie, Brynn Wainstein, Karen McCleary, Adam Nelson, Bradley Gardiner, Shafqat Inam, Xavier Badoux, Kris Ma, Claudia Toro, Diane Hanna, David Hughes, Rachel Conyers, Theresa Cole, Shiqi Stacie Wang, Lynette Chee, Jacqueline Fleming, Ashley Irish, Duncan Purtill, Julian Cooney, Peter Shaw, Siok-Keen Tey, Stewart Hunt, Elango Subramonia Pillai, George John, Michelle Ng, Shanti Ramachandran, Peter Hopkins, Daniel Chambers, Scott Campbell, Ross Francis, Nicole Isbel, Paula Marlton, Hilary Reddiex, Katherine K. Matthews, Meggie Voogt, Archana Panikkar, Leone Beagley, Sweera Rehan, Shannon Best, Jyothy Raju, Laetitia Le Texier, Pauline Crooks, Matthew Solomon, Lea Lekieffre, Sriganesh Srihari, Corey Smith, Rajiv Khanna

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract Adoptive T-cell immunotherapy holds great promise for the treatment of viral complications in immunocompromised patients resistant to standard anti-viral strategies. We present a retrospective analysis of 78 patients from 19 hospitals across

Externí odkaz: https://doaj.org/article/8c099c749c664bdd91639b09344ded19

A deep learning model to generate synthetic CT for prostate MR-only radiotherapy dose planning: a multicenter study

Autor: Safaa Tahri, Blanche Texier, Jean-Claude Nunes, Cédric Hemon, Pauline Lekieffre, Emma Collot, Hilda Chourak, Jennifer Le Guevelou, Peter Greer, Jason Dowling, Oscar Acosta, Igor Bessieres, Louis Marage, Adrien Boue-Rafle, Renaud De Crevoisier, Caroline Lafond, Anaïs Barateau

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

IntroductionFor radiotherapy based solely on magnetic resonance imaging (MRI), generating synthetic computed tomography scans (sCT) from MRI is essential for dose calculation. The use of deep learning (DL) methods to generate sCT from MRI has shown e

Externí odkaz: https://doaj.org/article/a1d51ded1429495bb38f6ed943c64561

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Ammonium and Sulfate Assimilation Is Widespread in Benthic Foraminifera

Autor: Charlotte LeKieffre, Thierry Jauffrais, Joan M. Bernhard, Helena L. Filipsson, Christiane Schmidt, Hélène Roberge, Olivier Maire, Giuliana Panieri, Emmanuelle Geslin, Anders Meibom

Publikováno v: Frontiers in Marine Science, Vol 9 (2022)

Nitrogen and sulfur are key elements in the biogeochemical cycles of marine ecosystems to which benthic foraminifera contribute significantly. Yet, cell-specific assimilation of ammonium, nitrate and sulfate by these protists is poorly characterized

Externí odkaz: https://doaj.org/article/2031ba35af624388bff091831246ec48

'Off-the-shelf’ allogeneic antigen-specific adoptive T-cell therapy for the treatment of multiple EBV-associated malignancies

Autor: Debottam Sinha, Sriganesh Srihari, Kirrliee Beckett, Laetitia Le Texier, Matthew Solomon, Archana Panikkar, George R Ambalathingal, Lea Lekieffre, Pauline Crooks, Sweera Rehan, Michelle A. Neller, Corey Smith, Rajiv Khanna

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)

Background Epstein-Barr virus (EBV), an oncogenic human gammaherpesvirus, is associated with a wide range of human malignancies of epithelial and B-cell origin. Recent studies have demonstrated promising safety and clinical efficacy of allogeneic ‘

Externí odkaz: https://doaj.org/article/7329e6da10914da88a5c8a14d23ece3f