A cross-metathesis approach to novel pantothenamide derivatives

Autor: Jinming Guan, Matthew Hachey, Lekha Puri, Vanessa Howieson, Kevin J. Saliba, Karine Auclair

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 963-968 (2016)

Pantothenamides are known for their in vitro antimicrobial activity. Our group has previously reported a new stereoselective route to access derivatives modified at the geminal dimethyl moiety. This route however fails in the addition of large substi

Externí odkaz: https://doaj.org/article/dbcf183f61cc4d72b14659b3a1196afe

Using artificial intelligence to read chest radiographs for tuberculosis detection: A multi-site evaluation of the diagnostic accuracy of three deep learning systems

Autor: Andrew J. Codlin, Jacob Creswell, Santat Sudrungrot, Collins N. Titahong, Lekha Puri, Bishwa Rai, E. Jane Carter, Melissa S. Sander, Zhi Zhen Qin, Lal Mani Adhikari, Sylvain N. Laah

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports

Deep learning (DL) neural networks have only recently been employed to interpret chest radiography (CXR) to screen and triage people for pulmonary tuberculosis (TB). No published studies have compared multiple DL systems and populations. We conducted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bce608af6cce648092b54762daf01f2
http://link.springer.com/article/10.1038/s41598-019-51503-3

Impact of fluoroquinolone treatment on delay of tuberculosis diagnosis: A systematic review and meta-analysis

Autor: Madhukar Pai, Genevieve Gore, Catherine A. Hogan, Lekha Puri

Publikováno v: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, Vol 6, Iss, Pp 1-7 (2017)
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases

Background: Fluoroquinolones are among the most commonly used antibiotics for the treatment of respiratory infections. Because fluoroquinolones show bactericidal activity against Mycobacterium tuberculosis, there is concern that their use can delay t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6a048417bda1d79bfe8f510f196fd0
http://www.sciencedirect.com/science/article/pii/S2405579416300419

High rates of obesity and greater associated disability among people with rheumatoid arthritis in Canada

Autor: María Celia Bazán Bardales, Susan J. Bartlett, Lekha Puri, Carol A. Hitchon, Ines Colmegna

Publikováno v: Clinical rheumatology. 35(2)

Obesity in rheumatoid arthritis has been associated with increased risk of comorbidities, larger medical costs, decreased quality of life, higher disease activity, and reduced therapeutic responses. We assessed the burden of obesity among rheumatoid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85765f8c8798d898affbe460350ac4a5
https://pubmed.ncbi.nlm.nih.gov/26712499